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Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
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Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans

DOI:
10.3791/61169-v

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07:04 min

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August 15, 2020

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,
1Institute of Molecular Biology and Biotechnology,Foundation for Research and Technology-Hellas, Greece, 2Department of Basic Sciences, Faculty of Medicine,University of Crete, Heraklion, 70013, Crete, Greece

Chapters

  • 00:00Introduction
  • 00:39Necrotic Cell Death-induced by Hyperactive Ion Channels
  • 04:06Protein Aggregate-induced Neurodegeneration
  • 05:58Representative Results: Monitor Necrotic Cell Death-Induced by Hyperactive Ion Channels and Protein Aggregate-induced Neurodegeneration
  • 06:30Conclusion

Summary

Automatic Translation

Automatic Translation

Here, we introduce and describe widely accessible methodologies utilizing some versatile nematode models, including hyperactivated ion channel-induced necrosis and protein aggregate-induced neurotoxicity, to monitor and dissect the cellular and molecular underpinnings of age-associated neurodegenerative diseases.

Tags

Keywords: Caenorhabditis ElegansNeurodegenerative DiseasesAlzheimer’sParkinson’sHuntington’s DiseaseProtein AggregatesNeurotoxicityNecrosisNematode CultureHeat ShockL1 LarvaeMicroscopyNeurodegeneration

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