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JoVE Journal Bioengineering
Modulierende Form von Polymersomen auf Polyesterbasis mit osmotischem Druck
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Modulierende Form von Polymersomen auf Polyesterbasis mit osmotischem Druck

Article DOI: 10.3791/62548-v • 06:01 min • April 21st, 2021
April 21st, 2021 •
1, 2, 1,3
1Department of Chemical and Biomolecular Engineering, Clemson University, 2Department of Biological Sciences, Clemson University, 3Department of Bioengineering, Clemson University

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Polymersomen sind selbstorganisierte polymere Vesikel, die in kugelförmigen Formen gebildet werden, um Gibbs freie Energie zu minimieren. Im Falle der Medikamentenabgabe sind länglichere Strukturen von Vorteil. Dieses Protokoll legt Methoden fest, um mehr stäbchenartige Polymersomen mit länglichen Seitenverhältnissen zu erzeugen, wobei Salz verwendet wird, um osmotischen Druck zu induzieren und das innere Vesikelvolumen zu reduzieren.

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Bioengineering Polymersome Nanomedizin Formmodulation Nanotechnologie Drug Delivery Polyester
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