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Das 6-Hydroxydopamin-Rattenmodell der Parkinson-Krankheit
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Das 6-Hydroxydopamin-Rattenmodell der Parkinson-Krankheit

Article DOI: 10.3791/62923-v • 08:10 min • October 27th, 2021
October 27th, 2021 •
1, 1, 1, 1, 1, 1
1Department of Psychology, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo

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Das 6-Hydroxydopamin (6-OHDA) -Modell wird seit Jahrzehnten verwendet, um das Verständnis der Parkinson-Krankheit voranzutreiben. In diesem Protokoll zeigen wir, wie man einseitige nigrostriatale Läsionen bei der Ratte durchführt, indem man 6-OHDA in das mediale Vorderhirnbündel injiziert, motorische Defizite beurteilt und Läsionen mit dem Schritttest vorhersagt.

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Neuroscience Ausgabe 176
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