A subscription to JoVE is required to view this content. Sign in or start your free trial.
Chapters
- 00:04Introduction
- 01:07Functional Isolation of Subsarcolemmal and Intermyofibrillar Mitochondria from Skeletal Muscle
- 02:15Mitochondrial Protein Import
- 06:33Results: The Evaluation of Protein Import Capacity into Mitochondria
- 08:17Conclusion
Mitochondria are key metabolic organelles that exhibit a high level of phenotypic plasticity in skeletal muscle. The import of proteins from the cytosol is a critical pathway for organelle biogenesis, essential for the expansion of the reticulum and the maintenance of mitochondrial function. Therefore, protein import serves as a barometer of cellular health.
