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JoVE Journal Bioengineering
Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics
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Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics

Article DOI: 10.3791/63223-v • 10:42 min • June 17th, 2022
June 17th, 2022 •
*1, *1,2, *1, 3,4, 1, 1, 1, 1, 1, 3,4, 2, 1,5
1Leslie Dan Faculty of Pharmacy, University of Toronto, 2Laboratory of Virology and Experimental Therapy (LAVITE), Department of Virology, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (Fiocruz), 3Department of Biomedical Engineering, Boston University, 4Molecular Biology, Cell Biology & Biochemistry Program, Graduate School of Arts and Sciences, Boston University, 5Department of Mechanical and Industrial Engineering, University of Toronto
* These authors contributed equally

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Summary
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Access to decentralized, low-cost, and high-capacity diagnostics that can be deployed into the community for decentralized testing is critical for combating global health crises. This manuscript describes how to build paper-based diagnostics for viral RNA sequences that can be detected with a portable optical reader.

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Design To Implementation Study Development Patient Validation Paper-based Toehold Switch Diagnostics Gene Circuit-based Diagnostics Low Cost Sensitive Nucleic Acids Platform Technology Clinical-grade Diagnostics Cell-free Toehold Switch Sensor Ebola Norovirus SARS-CoV-2 C.difficile Typhoid-causing Bacteria Severino Jefferson Rivero Da Silva Pouriya Bayat Post-doctoral Fellow PhD Student Zika Virus Genome Amplicons Toehold Switch Design Software Package
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