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Journal / Biology / Atomik Ölçekli Basamaklamadan Kaba Taneli…
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Atomik Ölçekli Basamaklamadan Kaba Taneli Difüzyona Kadar DNA Boyunca Transkripsiyon Faktörü Protein Hareketlerinin Yapı Tabanlı Simülasyonu ve Örneklemesi
Quantitation and Analysis of the Formation of HO-Endonuclease Stimulated Chromosomal Translocations by Single-Strand Annealing in Saccharomyces cerevisiae
Journal (Biology)
Quantitation and Analysis of the Formation of HO-Endonuclease Stimulated Chromosomal Translocations by Single-Strand Annealing in Saccharomyces cerevisiae
Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
Journal (Biology)
Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
 
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Atomik Ölçekli Basamaklamadan Kaba Taneli Difüzyona Kadar DNA Boyunca Transkripsiyon Faktörü Protein Hareketlerinin Yapı Tabanlı Simülasyonu ve Örneklemesi

Article DOI: 10.3791/63406-v • 09:17 min • March 1st, 2022
March 1st, 2022 •
*1, *1,2, 3,4, 4, 5,6,7
1Beijing Computational Science Research Center, 2Shenzhen JL Computational Science and Applied Research Institute, 3School of Medical Informatics and Engineering, Xuzhou Medical University, 4Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, 5Department of Physics and Astronomy, University of California, Irvine, 6Department of Chemistry, University of California, Irvine, 7NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine
* These authors contributed equally

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Bu protokolün amacı, örnek bir sistem olarak bir bitki transkripsiyon faktörü WRKY alan proteini kullanarak, DNA boyunca proteinin tek boyutlu difüzyonunun yapısal dinamiklerini ortaya çıkarmaktır. Bunu yapmak için, hem atomistik hem de kaba taneli moleküler dinamik simülasyonları ve kapsamlı hesaplamalı örneklemeler uygulanmıştır.

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