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Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring
DOI:

09:09 min

August 17, 2022

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Chapters

  • 00:04Introduction
  • 00:48Baseline Immunoreactivity (BIR) Testing
  • 01:56Tail Bleed Method for Blood Collection
  • 03:23Weight Based Method for Mating and Gestational Embryonic Day 12.5 Injection
  • 05:34Investigation of Alterations in Behavior in Adult MIA and Control Offspring (Optional)
  • 06:35Results: Investigating Susceptibility and Resilience of Offspring to Maternal Immune Activation
  • 08:15Conclusion

Summary

Automatic Translation

Maternal infection is a risk factor for neurodevelopmental disorders. Mouse models of maternal immune activation (MIA) may elucidate infection's impact on brain development and function. Here, general guidelines and a procedure are provided to produce reliably resilient and susceptible offspring exposed to MIA.

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