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Journal
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Biology
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一种改良的小鼠横主动脉收缩技术
JoVE Journal
Biology
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JoVE Journal
Biology
A Modified Technique for Transverse Aortic Constriction in Mice
Please note that all translations are automatically generated.
Click here for the English version.
一种改良的小鼠横主动脉收缩技术
DOI:
10.3791/64386-v
•
04:52 min
•
August 18, 2022
•
Kudusi Abuduwufuer*
1,2
,
James Jiqi Wang*
1,2
,
Huihui Li*
1,2
,
Chen Chen
2
1
Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College
,
Huazhong University of Science and Technology
,
2
Hubei Key Laboratory of Genetics and Molecular Mechanism of Cardiological Disorders, Tongji Hospital, Tongji Medical College
,
Huazhong University of Science and Technology
Chapters
00:04
Introduction
00:33
Preparation of Surgical Instruments
01:11
Animal Preparation
02:04
Constriction of Transverse Aorta and Postoperative Care
03:46
Results: Measurement of Heart Function via Ultrasound Imaging System
04:15
Conclusion
Summary
Automatic Translation
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Automatic Translation
本协议描述了一种使用自制牵开器进行微创横主动脉收缩(TAC)手术的改进和简化技术。该手术可以在没有呼吸机或显微镜的情况下进行,并引入压力超负荷,最终导致心脏肥大或心力衰竭。
Tags
Transverse Aortic Constriction
TAC Surgery
Mouse Model
Surgical Technique
Aortic Arch
Self-made Retractor
Needle Snare
Minimally Invasive
Anesthesia
Sterile Technique
Article
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