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Journal / Medicine / Brug af nikotin i en silica-eksponeret musemodel…
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Brug af nikotin i en silica-eksponeret musemodel til at fremme lungeepitel-mesenkymal overgang
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Brug af nikotin i en silica-eksponeret musemodel til at fremme lungeepitel-mesenkymal overgang

Article DOI: 10.3791/65127-v • 06:12 min • March 3rd, 2023
March 3rd, 2023 •
*1,2,3,4, *1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4
1Key Laboratory of Industrial Dust Control and Occupational Health of the Ministry of Education, Anhui University of Science and Technology, 2Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Anhui University of Science and Technology, 3Anhui Province Engineering Laboratory of Occupational Health and Safety, 4School of Medicine, Department of Medical Frontier Experimental Center, Anhui University of Science and Technology
* These authors contributed equally

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Denne undersøgelse beskriver en musemodel til undersøgelse af nikotins synergistiske effekt på udviklingen af lungefibrose i eksperimentelle silikosemus. Dual-exposure musemodellen simulerer den patologiske progression i lungen efter samtidig eksponering for nikotin og silica. De beskrevne metoder er enkle og meget reproducerbare.

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Nikotin silica lungeepitel-mesenkymal overgang silikose musemodel kronisk nikotinindtagelse gentagen eksponering for silica lungefibrose cigaretrøg subkutan injektion krystallinsk silicapulver inhalationseksponering dobbelteksponeret musemodel
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