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Journal / Medicine / Bir Insanlaşmış Fare Modeli epidermal melanin ve…
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Bir Insanlaşmış Fare Modeli epidermal melanin ve Karşı Koruma yanığı Farmakolojik İndüksiyon
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Bir Insanlaşmış Fare Modeli epidermal melanin ve Karşı Koruma yanığı Farmakolojik İndüksiyon

Article DOI: 10.3791/50670-v • 12:37 min • September 7th, 2013
September 7th, 2013 •
1,2, 1,3, 1,2, 1,2,3,4
1The Markey Cancer Center, University of Kentucky College of Medicine, 2Graduate Center for Toxicology, University of Kentucky College of Medicine, 3Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, 4Department of Pediatrics, University of Kentucky College of Medicine

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Epidermal melanin tenli UV duyarlı insan bir fare modelinde forskolin topik uygulanmasıyla elde edilir. En az eritematöz doz (MED) deneyi ile ölçüldüğü gibi güçlü bir UV aracılı enflamasyonun (güneş yanığı) karşı koruma koyulaşması deri ve epidermal cAMP düzeyleri farmakolojik manipülasyonu.

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Tıp Sayı 79 Cilt iltihap Fotometri Ultraviyole Işınları Cilt Pigmentasyon melanokortin 1 reseptör MC1R forskolinle cAMP ortalama eritematöz doz deri pigmentasyonu melanosit melanin güneş yanığı UV inflamasyon
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