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Mus Genome Engineering Brug Designer Nucleaser
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Mus Genome Engineering Brug Designer Nucleaser

Article DOI: 10.3791/50930-v • 12:04 min • April 2nd, 2014
April 2nd, 2014 •
1, 2, 2, 1
1Institute of Laboratory Animal Science, University of Zurich, 2Department of Genetics, Cell Biology & Development and Center for Genome Engineering, University of Minnesota

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Designer nucleaser såsom zinkfinger nukleaser (ZFNs) og transskription aktivator-lignende effektor nucleaser (TALENS) kan anvendes til at modificere genomet af muse præimplantations embryoner ved at udløse både homolog ende sammenføjning (NHEJ), og homolog rekombination (HR) veje. Disse fremskridt gør det muligt hurtig generering af mus med præcise genetiske modifikationer.

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Genetik Oocyte mikroinjektion Designer nukleaser ZFN TALEN Genome Engineering
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