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Journal / Bioengineering / Drug-induzierte Sensibilisierung der…
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Bioengineering

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JoVE Journal Bioengineering
Drug-induzierte Sensibilisierung der Adenylatzyklase
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Drug-induzierte Sensibilisierung der Adenylatzyklase: Assay Straffung und Miniaturisierung für Small Molecule-und siRNA-Screening-Anwendungen

Article DOI: 10.3791/51218-v • 09:39 min • January 27th, 2014
January 27th, 2014 •
1, 1, 1, 2, 1
1Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 2Quantitative Biology, Eli Lilly and Company

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Persistent Aktivierung inhibierenden G-Protein-gekoppelten Rezeptoren führt Sensibilisierung von Adenylylcyclase-Signalisierung. Um die wesentlichen molekularen Signalwege zu identifizieren, sind nonbiased Ansätze notwendig, aber diese Strategie erfordert die Entwicklung einer skalierbaren zellbasierten Assay-cAMP-Sensibilisierung. Hier beschreiben wir eine Sensibilisierung Assay für Kleinmolekül-und siRNA-Screening.

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Bioengineering Adenylatcyclase cAMP heterologe Sensibilisierung Überaktivierung D2 Dopamin μ-Opioid- siRNA
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