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JoVE Journal Bioengineering
Bioprintable alginato/gelatina idrogel 3D In Vitro sistemi modello inducono la formazione di sferoide di cella
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Bioprintable alginato/gelatina idrogel 3D In Vitro sistemi modello inducono la formazione di sferoide di cella

Article DOI: 10.3791/57826-v • 16:20 min • July 2nd, 2018
July 2nd, 2018 •
*1, *2,3, 2, 4, 4, 3, 2,5
1Department of Mechanical Engineering, McGill University Montreal, 2Department of Bioengineering, McGill University Montreal, 3Department of Molecular Biology, Instituto Potosino de Investigación Científica y Tecnológica, A.C. (IPICyT), 4Department of Mining and Materials Engineering, McGill University Montreal, 5Department of Biomedical Engineering, McGill University Montreal
* These authors contributed equally

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Abbiamo sviluppato un modello di cancro al seno eterogeneo costituito da cellule del tumore e del fibroblasto immortalate incorporate in un bioink di alginato/gelatina bioprintable. Il modello ricapitola il microambiente tumorale in vivo e facilita la formazione di sferoidi multicellulari tumore, producendo la comprensione dei meccanismi di tumorigenesi di guida.

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Bioingegneria problema 137 3D multimateriali idrogel le cellule tumorali sferoidi tumore alginato gelatina
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