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Journal / Chemistry / Kjemisk deaktivering av E3 Ubiquitin Ligase…
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JoVE Journal Chemistry
Kjemisk deaktivering av E3 Ubiquitin Ligase Cereblon av Pomalidomide-baserte homo-PROTACs
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Kjemisk deaktivering av E3 Ubiquitin Ligase Cereblon av Pomalidomide-baserte homo-PROTACs

Article DOI: 10.3791/59472-v • 10:44 min • May 15th, 2019
May 15th, 2019 •
*1, *2, 1, 2, 2, 1
1Department of Internal Medicine III, University Hospital Ulm, 2Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn
* These authors contributed equally

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Dette arbeidet beskriver syntese og karakterisering av en pomalidomide-basert, bifunctional homo-PROTAC som en ny tilnærming for å indusere ubiqitinering og degradering av E3 ubiquitin ligase cereblon (CRBN), målet for Thalidomid analogs.

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Kjemi CRBN PROTAC IMiD pomalidomide ubiquitin ligase flere myelom proteasomet
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