Armin Buschauer Institute of Pharmacy University of Regensburg Biography Publications Institution JoVE Articles Armin Buschauer has not added a biography. If you are Armin Buschauer and would like to personalize this page please email our Author Liaison for assistance. Publications Basal Histamine H Receptor Activation: Agonist Mimicry by the Diphenylalanine Motif Chemistry (Weinheim an Der Bergstrasse, Germany). Nov, 2019 | Pubmed ID: 31498478 [H]UR-DEBa176: A 2,4-Diaminopyrimidine-Type Radioligand Enabling Binding Studies at the Human, Mouse, and Rat Histamine H Receptors Journal of Medicinal Chemistry. Sep, 2019 | Pubmed ID: 31469288 Split Luciferase-based Assay for Simultaneous Analyses of the Ligand Concentration- and Time-dependent Recruitment of β-arrestin2 Analytical Biochemistry. 05, 2019 | Pubmed ID: 30853375 Alkyl Derivatives of 1,3,5-triazine As Histamine H Receptor Ligands Bioorganic & Medicinal Chemistry. 04, 2019 | Pubmed ID: 30792106 A Split Luciferase-based Probe for Quantitative Proximal Determination of Gα Signalling in Live Cells Scientific Reports. 11, 2018 | Pubmed ID: 30464299 Highly Potent, Stable, and Selective Dimeric Hetarylpropylguanidine-Type Histamine H Receptor Agonists ACS Omega. Mar, 2018 | Pubmed ID: 30221224 Tariquidar-Related Chalcones and Ketones As ABCG2 Modulators ACS Medicinal Chemistry Letters. Aug, 2018 | Pubmed ID: 30128080 Structural Basis of Ligand Binding Modes at the Neuropeptide Y Y Receptor Nature. 04, 2018 | Pubmed ID: 29670288 Structural Basis of Small-molecule Inhibition of Human Multidrug Transporter ABCG2 Nature Structural & Molecular Biology. Apr, 2018 | Pubmed ID: 29610494 Molecular Mechanisms of Biased and Probe-Dependent Signaling at CXC-Motif Chemokine Receptor CXCR3 Induced by Negative Allosteric Modulators Molecular Pharmacology. 04, 2018 | Pubmed ID: 29343553 In Search of NPY YR Antagonists: Incorporation of Carbamoylated Arginine, Aza-Amino Acids, or D-Amino Acids into Oligopeptides Derived from the C-Termini of the Endogenous Agonists ACS Omega. Jul, 2017 | Pubmed ID: 30023699 Fluorescence- and Radiolabeling of [Lys,Nle]hPP Yields Molecular Tools for the NPY Y Receptor Bioconjugate Chemistry. 04, 2017 | Pubmed ID: 28345900 Prototypic F-Labeled Argininamide-Type Neuropeptide Y YR Antagonists As Tracers for PET Imaging of Mammary Carcinoma ACS Medicinal Chemistry Letters. Mar, 2017 | Pubmed ID: 28337321 High Affinity Agonists of the Neuropeptide Y (NPY) Y4 Receptor Derived from the C-Terminal Pentapeptide of Human Pancreatic Polypeptide (hPP): Synthesis, Stereochemical Discrimination, and Radiolabeling Journal of Medicinal Chemistry. 07, 2016 | Pubmed ID: 27223253 Conformational Restriction and Enantioseparation Increase Potency and Selectivity of Cyanoguanidine-Type Histamine H4 Receptor Agonists Journal of Medicinal Chemistry. Apr, 2016 | Pubmed ID: 27007611 BK K+ Channel Blockade Inhibits Radiation-induced Migration/brain Infiltration of Glioblastoma Cells Oncotarget. Mar, 2016 | Pubmed ID: 26893360 Mimicking of Arginine by Functionalized N(ω)-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples Journal of Medicinal Chemistry. Mar, 2016 | Pubmed ID: 26824643 Flavonoid Derivatives As Selective ABCC1 Modulators: Synthesis and Functional Characterization European Journal of Medicinal Chemistry. Feb, 2016 | Pubmed ID: 26774038 Histamine H(1)- and H(4)-receptor Signaling Cooperatively Regulate MAPK Activation Biochemical Pharmacology. Dec, 2015 | Pubmed ID: 26385311 Esters of Bendamustine Are by Far More Potent Cytotoxic Agents Than the Parent Compound Against Human Sarcoma and Carcinoma Cells PloS One. 2015 | Pubmed ID: 26196503 Topotecan-induced ABCG2 Expression in MCF-7 Cells is Associated with Decreased CD24 and EpCAM Expression and a Loss of Tumorigenicity Cytometry. Part A : the Journal of the International Society for Analytical Cytology. Aug, 2015 | Pubmed ID: 25892097 Toward Labeled Argininamide-Type NPY Y1 Receptor Antagonists: Identification of a Favorable Propionylation Site in BIBO3304 Archiv Der Pharmazie. Jun, 2015 | Pubmed ID: 25884646 High Performance Anion Exchange Chromatography with Pulsed Amperometric Detection (HPAEC-PAD) for the Sensitive Determination of Hyaluronan Oligosaccharides Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Apr, 2015 | Pubmed ID: 25768984 M2 Subtype Preferring Dibenzodiazepinone-type Muscarinic Receptor Ligands: Effect of Chemical Homo-dimerization on Orthosteric (and Allosteric?) Binding Bioorganic & Medicinal Chemistry. Jul, 2015 | Pubmed ID: 25650309 Dimeric Carbamoylguanidine-type Histamine H2 Receptor Ligands: A New Class of Potent and Selective Agonists Bioorganic & Medicinal Chemistry. Jul, 2015 | Pubmed ID: 25639885 The Extracellular Loop 2 (ECL2) of the Human Histamine H4 Receptor Substantially Contributes to Ligand Binding and Constitutive Activity PloS One. 2015 | Pubmed ID: 25629160 No Evidence for Histamine H4 Receptor in Human Monocytes The Journal of Pharmacology and Experimental Therapeutics. Dec, 2014 | Pubmed ID: 25273276 Synthesis and Functional Characterization of Imbutamine Analogs As Histamine H3 and H4 Receptor Ligands Archiv Der Pharmazie. Feb, 2014 | Pubmed ID: 24493592 Benzanilide-Biphenyl Replacement: A Bioisosteric Approach to Quinoline Carboxamide-Type ABCG2 Modulators ACS Medicinal Chemistry Letters. Apr, 2013 | Pubmed ID: 24900683 Synthesis and Dual Histamine H₁ and H₂ Receptor Antagonist Activity of Cyanoguanidine Derivatives Molecules (Basel, Switzerland). Nov, 2013 | Pubmed ID: 24248146 Replacement of Thr32 and Gln34 in the C-terminal Neuropeptide Y Fragment 25-36 by Cis-cyclobutane and Cis-cyclopentane β-amino Acids Shifts Selectivity Toward the Y(4) Receptor Journal of Medicinal Chemistry. Nov, 2013 | Pubmed ID: 24090364 Dimeric Argininamide-type Neuropeptide Y Receptor Antagonists: Chiral Discrimination Between Y1 and Y4 Receptors Bioorganic & Medicinal Chemistry. Nov, 2013 | Pubmed ID: 24074877 Luciferase Reporter Gene Assay on Human, Murine and Rat Histamine H4 Receptor Orthologs: Correlations and Discrepancies Between Distal and Proximal Readouts PloS One. 2013 | Pubmed ID: 24023919 Dissociations in the Effects of β2-adrenergic Receptor Agonists on CAMP Formation and Superoxide Production in Human Neutrophils: Support for the Concept of Functional Selectivity PloS One. 2013 | Pubmed ID: 23741338 Molecular and Cellular Analysis of Human Histamine Receptor Subtypes Trends in Pharmacological Sciences. Jan, 2013 | Pubmed ID: 23254267 Species-dependent Activities of G-protein-coupled Receptor Ligands: Lessons from Histamine Receptor Orthologs Trends in Pharmacological Sciences. Jan, 2013 | Pubmed ID: 23228711 The Neuropeptide Y Y(1) Receptor: a Diagnostic Marker? Expression in Mcf-7 Breast Cancer Cells is Down-regulated by Antiestrogens in Vitro and in Xenografts PloS One. 2012 | Pubmed ID: 23236424 The Bivalent Ligand Approach Leads to Highly Potent and Selective Acylguanidine-type Histamine H₂ Receptor Agonists Journal of Medicinal Chemistry. Feb, 2012 | Pubmed ID: 22216892 Fast Counter-electroosmotic Capillary Electrophoresis-time-of-flight Mass Spectrometry of Hyaluronan Oligosaccharides Analytical and Bioanalytical Chemistry. Mar, 2012 | Pubmed ID: 21800126 Synthesis and Histamine H(3) and H(4) Receptor Activity of Conformationally Restricted Cyanoguanidines Related to UR-PI376 Archiv Der Pharmazie. Dec, 2011 | Pubmed ID: 21987304 Design of Benzimidazole- and Benzoxazole-2-thione Derivatives As Inhibitors of Bacterial Hyaluronan Lyase European Journal of Medicinal Chemistry. Sep, 2011 | Pubmed ID: 21803461 Role of the Second and Third Extracellular Loops of the Histamine H(4) Receptor in Receptor Activation Naunyn-Schmiedeberg's Archives of Pharmacology. Sep, 2011 | Pubmed ID: 21800093 Functional Reconstitution of Human Neuropeptide Y (NPY) Y(2) and Y(4) Receptors in Sf9 Insect Cells Journal of Receptor and Signal Transduction Research. Aug, 2011 | Pubmed ID: 21745157 Expression and Functional Properties of Canine, Rat, and Murine Histamine H₄ Receptors in Sf9 Insect Cells Naunyn-Schmiedeberg's Archives of Pharmacology. May, 2011 | Pubmed ID: 21359967 Histamine H4 Receptor Agonists Bioorganic & Medicinal Chemistry Letters. Dec, 2010 | Pubmed ID: 21044842 G Protein-coupled Receptors Function As Logic Gates for Nanoparticle Binding and Cell Uptake Proceedings of the National Academy of Sciences of the United States of America. Jun, 2010 | Pubmed ID: 20498042 Chiral NG-acylated Hetarylpropylguanidine-type Histamine H2 Receptor Agonists Do Not Show Significant Stereoselectivity Bioorganic & Medicinal Chemistry Letters. May, 2010 | Pubmed ID: 20409707 Synthesis and Structure-activity Relationships of Cyanoguanidine-type and Structurally Related Histamine H4 Receptor Agonists Journal of Medicinal Chemistry. Oct, 2009 | Pubmed ID: 19791743 N(G)-acylated Imidazolylpropylguanidines As Potent Histamine H4 Receptor Agonists: Selectivity by Variation of the N(G)-substituent Journal of Medicinal Chemistry. Apr, 2009 | Pubmed ID: 19317445 Potent and Selective Inhibitors of Breast Cancer Resistance Protein (ABCG2) Derived from the P-glycoprotein (ABCB1) Modulator Tariquidar Journal of Medicinal Chemistry. Feb, 2009 | Pubmed ID: 19170519 Guanidine-acylguanidine Bioisosteric Approach in the Design of Radioligands: Synthesis of a Tritium-labeled N(G)-propionylargininamide ([3H]-UR-MK114) As a Highly Potent and Selective Neuropeptide Y Y1 Receptor Antagonist Journal of Medicinal Chemistry. Dec, 2008 | Pubmed ID: 19053784 Acylguanidines As Bioisosteres of Guanidines: NG-acylated Imidazolylpropylguanidines, a New Class of Histamine H2 Receptor Agonists Journal of Medicinal Chemistry. Nov, 2008 | Pubmed ID: 18950149 Frontiers in Medicinal Chemistry in Regensburg ChemMedChem. Aug, 2008 | Pubmed ID: 18655207 Effect of the ABCB1 Modulators Elacridar and Tariquidar on the Distribution of Paclitaxel in Nude Mice Journal of Cancer Research and Clinical Oncology. May, 2008 | Pubmed ID: 17932689 Isoenzyme-specific Differences in the Degradation of Hyaluronic Acid by Mammalian-type Hyaluronidases Glycoconjugate Journal. Feb, 2008 | Pubmed ID: 17620008 Mutations of Cys-17 and Ala-271 in the Human Histamine H2 Receptor Determine the Species Selectivity of Guanidine-type Agonists and Increase Constitutive Activity The Journal of Pharmacology and Experimental Therapeutics. Jun, 2007 | Pubmed ID: 17347323 Constitutive Activity and Ligand Selectivity of Human, Guinea Pig, Rat, and Canine Histamine H2 Receptors The Journal of Pharmacology and Experimental Therapeutics. Jun, 2007 | Pubmed ID: 17332265 Inhibitors of Kinesin Eg5: Antiproliferative Activity of Monastrol Analogues Against Human Glioblastoma Cells Cancer Chemotherapy and Pharmacology. Feb, 2007 | Pubmed ID: 16703323 Fluorescence- and Luminescence-based Methods for the Determination of Affinity and Activity of Neuropeptide Y2 Receptor Ligands European Journal of Pharmacology. Dec, 2006 | Pubmed ID: 17027743 Novel 6-O-acylated Vitamin C Derivatives As Hyaluronidase Inhibitors with Selectivity for Bacterial Lyases Bioorganic & Medicinal Chemistry Letters. Oct, 2006 | Pubmed ID: 16908142 A Simple and Powerful Flow Cytometric Method for the Simultaneous Determination of Multiple Parameters at G Protein-coupled Receptor Subtypes Chembiochem : a European Journal of Chemical Biology. Sep, 2006 | Pubmed ID: 16888730 Platelet-derived Growth Factor Receptor Independent Proliferation of Human Glioblastoma Cells: Selective Tyrosine Kinase Inhibitors Lack Antiproliferative Activity Journal of Cancer Research and Clinical Oncology. Sep, 2006 | Pubmed ID: 16736141 Design of New Benzoxazole-2-thione-derived Inhibitors of Streptococcus Pneumoniae Hyaluronan Lyase: Structure of a Complex with a 2-phenylindole Glycobiology. Aug, 2006 | Pubmed ID: 16638841 Sulphated Oligosaccharides As Inhibitors of Hyaluronidases from Bovine Testis, Bee Venom and Streptococcus Agalactiae Planta Medica. Aug, 2005 | Pubmed ID: 16142636 Construction and Validation of a Microprocessor Controlled Extracorporal Circuit in Rats for the Optimization of Isolated Limb Perfusion Archiv Der Pharmazie. Dec, 2004 | Pubmed ID: 15597400 Structure-activity Relationships of Histamine H2 Receptor Ligands Mini Reviews in Medicinal Chemistry. Nov, 2004 | Pubmed ID: 15544555 L-Ascorbic Acid 6-hexadecanoate, a Potent Hyaluronidase Inhibitor. X-ray Structure and Molecular Modeling of Enzyme-inhibitor Complexes The Journal of Biological Chemistry. Oct, 2004 | Pubmed ID: 15322107 Functional Expression of the Interleukin-11 Receptor Alpha-chain and Evidence of Antiapoptotic Effects in Human Colonic Epithelial Cells The Journal of Biological Chemistry. Mar, 2004 | Pubmed ID: 14701802 Transport of Paclitaxel (Taxol) Across the Blood-brain Barrier in Vitro and in Vivo The Journal of Clinical Investigation. Nov, 2002 | Pubmed ID: 12417570 Polyamine Levels of Human Colorectal Adenocarcinomas Are Correlated with Tumor Stage and Grade International Journal of Colorectal Disease. Nov, 2002 | Pubmed ID: 12355213 Protocollo di dosing stepwise per aumentare la velocità effettiva nei dati GPCR basati su impeditto per etichetta Judith A. Stolwijk1, Anne-Kathrin Mildner1, Christian Kade1, Michael Skiba1, Guenther Bernhardt2, Armin Buschauer2, Harald Huebner3, Peter Gmeiner3, Joachim Wegener1,4 1Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, 2Institute of Pharmacy, University of Regensburg, 3Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nuernberg, 4Fraunhofer Research Institution for Microsystems and Solid State Technologies EMFT JoVE 60686 Biochemistry
Protocollo di dosing stepwise per aumentare la velocità effettiva nei dati GPCR basati su impeditto per etichetta Judith A. Stolwijk1, Anne-Kathrin Mildner1, Christian Kade1, Michael Skiba1, Guenther Bernhardt2, Armin Buschauer2, Harald Huebner3, Peter Gmeiner3, Joachim Wegener1,4 1Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, 2Institute of Pharmacy, University of Regensburg, 3Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nuernberg, 4Fraunhofer Research Institution for Microsystems and Solid State Technologies EMFT JoVE 60686 Biochemistry
