Arthur Melms Department of Neurology University Hospital Erlangen Biography Publications Institution JoVE Articles Arthur Melms has not added a biography. If you are Arthur Melms and would like to personalize this page please email our Author Liaison for assistance. Publications Exploring the MHC-peptide Matrix of Central Tolerance in the Human Thymus Nature Communications. Jun, 2013 | Pubmed ID: 23783831 The Different Roles of the Thymus in the Pathogenesis of the Various Myasthenia Gravis Subtypes Autoimmunity Reviews. Jul, 2013 | Pubmed ID: 23535159 Plasma Exchange Is Effective in a 13-Year-Old Girl with Steroid-Resistant Bilateral Optic Neuritis Neuropediatrics. Mar, 2013 | Pubmed ID: 23468279 Natural HLA Class I Ligands from Glioblastoma: Extending the Options for Immunotherapy Journal of Neuro-oncology. Feb, 2013 | Pubmed ID: 23263746 Recognition Performance Differentiates Between Elderly Patients in the Long Term Course of Secondary Progressive Multiple Sclerosis and Amnestic Mild Cognitive Impairment Multiple Sclerosis (Houndmills, Basingstoke, England). May, 2013 | Pubmed ID: 23166118 Plasma Levels of Soluble Glycoprotein VI (sGPVI) Are Associated with Ischemic Stroke Platelets. Dec, 2012 | Pubmed ID: 23215725 Serum and Cerebrospinal Fluid Levels of Transthyretin in Lewy Body Disorders with and Without Dementia PloS One. 2012 | Pubmed ID: 23133543 Risk for Myasthenia Gravis Maps to a (151) Pro→Ala Change in TNIP1 and to Human Leukocyte Antigen-B*08 Annals of Neurology. Dec, 2012 | Pubmed ID: 23055271 Current Concepts of the Interventional Treatment of Proximal Supraaortic Vessel Stenosis VASA. Zeitschrift Für Gefässkrankheiten. Sep, 2012 | Pubmed ID: 22915528 Elevated Plasma Levels of Neuropeptide Proenkephalin a Predict Mortality and Functional Outcome in Ischemic Stroke Journal of the American College of Cardiology. Jul, 2012 | Pubmed ID: 22813614 Cathepsin S Dominates Autoantigen Processing in Human Thymic Dendritic Cells Journal of Autoimmunity. Jun, 2012 | Pubmed ID: 22424724 Contrasting Disease Patterns in Seropositive and Seronegative Neuromyelitis Optica: A Multicentre Study of 175 Patients Journal of Neuroinflammation. 2012 | Pubmed ID: 22260418 Anti-LRP4 Autoantibodies in AChR- and MuSK-antibody-negative Myasthenia Gravis Journal of Neurology. Mar, 2012 | Pubmed ID: 21814823 Confirmation of R132H Mutation of Isocitrate Dehydrogenase 1 As an Independent Prognostic Factor in Anaplastic Astrocytoma Acta Neuropathologica. Nov, 2011 | Pubmed ID: 21983902 Serum and Cerebrospinal Fluid Uric Acid Levels in Lewy Body Disorders: Associations with Disease Occurrence and Amyloid-β Pathway Journal of Alzheimer's Disease : JAD. 2011 | Pubmed ID: 21765209 Autoantibodies Against Amyloid and Glial-derived Antigens Are Increased in Serum and Cerebrospinal Fluid of Lewy Body-associated Dementias Journal of Alzheimer's Disease : JAD. 2011 | Pubmed ID: 21593566 Frequency and Syndrome Specificity of Antibodies to Aquaporin-4 in Neurological Patients with Rheumatic Disorders Multiple Sclerosis (Houndmills, Basingstoke, England). Sep, 2011 | Pubmed ID: 21543553 CD62L(high) Treg Cells with Superior Immunosuppressive Properties Accumulate Within the CNS During Remissions of EAE Brain, Behavior, and Immunity. Jan, 2011 | Pubmed ID: 20837133 Neprilysin Activity in Cerebrospinal Fluid is Associated with Dementia and Amyloid-β42 Levels in Lewy Body Disease Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20858953 Aquaporin 4 Antibody Positive Central Nervous System Autoimmunity and Multiple Sclerosis Are Characterized by a Distinct Profile of Antibodies to Herpes Viruses Neurochemistry International. Nov, 2010 | Pubmed ID: 20705110 The CST3 BB Genotype and Low Cystatin C Cerebrospinal Fluid Levels Are Associated with Dementia in Lewy Body Disease Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20157249 Prednisolone Treatment Induces Tolerogenic Dendritic Cells and a Regulatory Milieu in Myasthenia Gravis Patients Journal of Immunology (Baltimore, Md. : 1950). Jul, 2009 | Pubmed ID: 19542375 No Differences of Butyrylcholinesterase Protein Activity and Allele Frequency in Lewy Body Diseases Neurobiology of Disease. Aug, 2009 | Pubmed ID: 19481150 The Autoimmunity-related Polymorphism PTPN22 1858C/T is Associated with Anti-titin Antibody-positive Myasthenia Gravis Human Immunology. Jul, 2009 | Pubmed ID: 19406179 Differential Modulation of CNS-specific Effector and Regulatory T Cells During Tolerance Induction by Recombinant Invariant Chains in Vivo Brain, Behavior, and Immunity. Aug, 2009 | Pubmed ID: 19362139 A Single-nucleotide Polymorphism of the Osteopontin Gene May Contribute to a Susceptibility to Lewy Body Disease Journal of Neural Transmission (Vienna, Austria : 1996). May, 2009 | Pubmed ID: 19340392 Cortical PIB Binding in Lewy Body Disease is Associated with Alzheimer-like Characteristics Neurobiology of Disease. Apr, 2009 | Pubmed ID: 19162186 Cathepsin W Expressed Exclusively in CD8+ T Cells and NK Cells, is Secreted During Target Cell Killing but is Not Essential for Cytotoxicity in Human CTLs Experimental Hematology. Feb, 2009 | Pubmed ID: 19100676 Cathepsin G is Differentially Expressed in Primary Human Antigen-presenting Cells Cellular Immunology. 2009 | Pubmed ID: 19036358 Complementary Strategies to Elucidate T Helper Cell Epitopes in Myasthenia Gravis Journal of Neuroimmunology. Sep, 2008 | Pubmed ID: 18649950 Congestive Radiculopathy Neurology. Feb, 2008 | Pubmed ID: 18299528 Polymorphisms in the Cathepsin L2 (CTSL2) Gene Show Association with Type 1 Diabetes and Early-onset Myasthenia Gravis Human Immunology. Sep, 2007 | Pubmed ID: 17869649 Dendritic Cell-regulatory T-cell Interactions Control Self-directed Immunity Immunology and Cell Biology. Nov-Dec, 2007 | Pubmed ID: 17592494 Treatment of Active Secondary Progressive Multiple Sclerosis with Treosulfan Journal of Neurology. Jul, 2007 | Pubmed ID: 17446994 HLA-G Expression Defines a Novel Regulatory T-cell Subset Present in Human Peripheral Blood and Sites of Inflammation Blood. Jul, 2007 | Pubmed ID: 17371944 Osteopontin is Elevated in Parkinson's Disease and Its Absence Leads to Reduced Neurodegeneration in the MPTP Model Neurobiology of Disease. Mar, 2007 | Pubmed ID: 17188882 Specificity of Human Cathepsin S Determined by Processing of Peptide Substrates and MHC Class II-associated Invariant Chain Biological Chemistry. Oct-Nov, 2006 | Pubmed ID: 17081125 Induction of Autoimmunity by Expansion of Autoreactive CD4+CD62Llow Cells in Vivo Journal of Immunology (Baltimore, Md. : 1950). Oct, 2006 | Pubmed ID: 16982873 Expression of Toll-like Receptors by Human Muscle Cells in Vitro and in Vivo: TLR3 is Highly Expressed in Inflammatory and HIV Myopathies, Mediates IL-8 Release and Up-regulation of NKG2D-ligands FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2006 | Pubmed ID: 16293707 CNS Involvement Occurs More Frequently in Patients with Behçet's Disease Under Cyclosporin A (CSA) Than Under Other Medications--results of a Retrospective Analysis of 117 Cases Clinical Rheumatology. Jul, 2006 | Pubmed ID: 16261281 Delayed Resolution of White Matter Changes Following Therapy of B Burgdorferi Encephalitis Neurology. Feb, 2005 | Pubmed ID: 15728315 3-hydroxy-3-methylglutaryl-CoA Lyase Deficiency in an Adult with Leukoencephalopathy Annals of Neurology. Nov, 2004 | Pubmed ID: 15505778 MHC Class II Isotype- and Allele-specific Attenuation of Experimental Autoimmune Encephalomyelitis Journal of Immunology (Baltimore, Md. : 1950). Aug, 2004 | Pubmed ID: 15294998 Lack of Pathogenicity of Immunodominant T and B Cell Determinants of the Nicotinic Acetylcholine Receptor Epsilon-chain Journal of Neuroimmunology. Jul, 2004 | Pubmed ID: 15223236 A Structurally Available Encephalitogenic Epitope of Myelin Oligodendrocyte Glycoprotein Specifically Induces a Diversified Pathogenic Autoimmune Response Journal of Immunology (Baltimore, Md. : 1950). Jul, 2004 | Pubmed ID: 15210822 Cathepsin G, and Not the Asparagine-specific Endoprotease, Controls the Processing of Myelin Basic Protein in Lysosomes from Human B Lymphocytes Journal of Immunology (Baltimore, Md. : 1950). May, 2004 | Pubmed ID: 15100291 Different Patterns of Nicotinic Acetylcholine Receptor Subunit Transcription in Human Thymus Journal of Neuroimmunology. Apr, 2004 | Pubmed ID: 15020075 Analysis of Autoreactive CD4 T Cells in Experimental Autoimmune Encephalomyelitis After Primary and Secondary Challenge Using MHC Class II Tetramers Journal of Immunology (Baltimore, Md. : 1950). Mar, 2004 | Pubmed ID: 14978089 Expression of the B7-related Molecule ICOSL by Human Glioma Cells in Vitro and in Vivo Glia. Dec, 2003 | Pubmed ID: 14603470 Action of Treosulfan in Myelin-oligodendrocyte-glycoprotein-induced Experimental Autoimmune Encephalomyelitis and Human Lymphocytes Journal of Neuroimmunology. Nov, 2003 | Pubmed ID: 14597095 Cathepsin V is Involved in the Degradation of Invariant Chain in Human Thymus and is Overexpressed in Myasthenia Gravis The Journal of Clinical Investigation. Aug, 2003 | Pubmed ID: 12925692 Human Muscle Cells Express a B7-related Molecule, B7-H1, with Strong Negative Immune Regulatory Potential: a Novel Mechanism of Counterbalancing the Immune Attack in Idiopathic Inflammatory Myopathies FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Oct, 2003 | Pubmed ID: 12923066 The CD28 Related Molecule ICOS: T Cell Modulation in the Presence and Absence of B7.1/2 and Regulational Expression in Multiple Sclerosis Journal of Neuroimmunology. Jul, 2003 | Pubmed ID: 12864987 Antigen Processing and Presentation in Human Muscle: Cathepsin S is Critical for MHC Class II Expression and Upregulated in Inflammatory Myopathies Journal of Neuroimmunology. May, 2003 | Pubmed ID: 12742663 Human Herpesvirus 6 in Serum and Spinal Fluid of Patients with Multiple Sclerosis? Archives of Neurology. Apr, 2003 | Pubmed ID: 12707085 Muscle Fibres and Cultured Muscle Cells Express the B7.1/2-related Inducible Co-stimulatory Molecule, ICOSL: Implications for the Pathogenesis of Inflammatory Myopathies Brain : a Journal of Neurology. May, 2003 | Pubmed ID: 12690043 The Non-classical MHC Molecule HLA-G Protects Human Muscle Cells from Immune-mediated Lysis: Implications for Myoblast Transplantation and Gene Therapy Brain : a Journal of Neurology. Jan, 2003 | Pubmed ID: 12477705 High Immunogenicity of Intracellular Myelin Oligodendrocyte Glycoprotein Epitopes Journal of Immunology (Baltimore, Md. : 1950). Jul, 2002 | Pubmed ID: 12077287 A Functional Role of HLA-G Expression in Human Gliomas: an Alternative Strategy of Immune Escape Journal of Immunology (Baltimore, Md. : 1950). May, 2002 | Pubmed ID: 11971028 Isolation of Myeloid Dendritic Cells and Epithelial Cells from Human Thymus Christina Stoeckle1,2, Ioanna A. Rota1, Eva Tolosa3, Christoph Haller4, Arthur Melms5, Eleni Adamopoulou1 1Department of General Neurology, Hertie Institute for Clinical Brain Research, 2Institute of Pharmacology, University of Bern, 3Department of Immunology, University Medical Center Hamburg-Eppendorf, 4Department of Thoracic and Cardiovascular Surgery, University Clinic Tuebingen, 5Department of Neurology, University Hospital Erlangen JoVE 50951 Immunology and Infection
Isolation of Myeloid Dendritic Cells and Epithelial Cells from Human Thymus Christina Stoeckle1,2, Ioanna A. Rota1, Eva Tolosa3, Christoph Haller4, Arthur Melms5, Eleni Adamopoulou1 1Department of General Neurology, Hertie Institute for Clinical Brain Research, 2Institute of Pharmacology, University of Bern, 3Department of Immunology, University Medical Center Hamburg-Eppendorf, 4Department of Thoracic and Cardiovascular Surgery, University Clinic Tuebingen, 5Department of Neurology, University Hospital Erlangen JoVE 50951 Immunology and Infection
