Basil Rigas Department of Preventive Medicine Stony Brook University Biography Publications Institution JoVE Articles Basil Rigas has not added a biography. If you are Basil Rigas and would like to personalize this page please email our Author Liaison for assistance. Publications NSAID-induced Corneal Melt: Clinical Importance, Pathogenesis, and Risk Mitigation Survey of Ophthalmology. Jan - Feb, 2020 | Pubmed ID: 31306671 Phospho-valproic Acid (MDC-1112) Reduces Pancreatic Cancer Growth in Patient-derived Tumor Xenografts and KPC Mice: Enhanced Efficacy when Combined with Gemcitabine Carcinogenesis. Oct, 2019 | Pubmed ID: 31584613 Phospho-valproic Acid (MDC-1112) Suppresses Glioblastoma Growth in Preclinical Models Through the Inhibition of STAT3 Phosphorylation Carcinogenesis. Apr, 2019 | Pubmed ID: 30994173 A New Rabbit Model of Chronic Dry Eye Disease Induced by Complete Surgical Dacryoadenectomy Current Eye Research. Aug, 2019 | Pubmed ID: 30983427 The Ocular Pharmacokinetics and Biodistribution of Phospho-sulindac (OXT-328) Formulated in Nanoparticles: Enhanced and Targeted Tissue Drug Delivery International Journal of Pharmaceutics. Feb, 2019 | Pubmed ID: 30597269 Correction: The Chemoprevention of Ovarian Cancer: the Need and the Options Current Pharmacology Reports. 2018 | Pubmed ID: 31187022 The Chemoprevention of Ovarian Cancer: the Need and the Options Current Pharmacology Reports. 2018 | Pubmed ID: 30363743 [Corrigendum] Phospho‑valproic Acid Inhibits Pancreatic Cancer Growth in Mice: Enhanced Efficacy by Its Formulation in Poly‑(L)‑lactic Acid‑poly(ethylene Glycol) Nanoparticles International Journal of Oncology. 12, 2018 | Pubmed ID: 30320367 Phosphosulindac is Efficacious in an Improved Concanavalin A-based Rabbit Model of Chronic Dry Eye Disease Translational Research : the Journal of Laboratory and Clinical Medicine. 08, 2018 | Pubmed ID: 29702077 Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells Stem Cell Reports. 11, 2017 | Pubmed ID: 29056331 Phospho-valproic Acid Inhibits Pancreatic Cancer Growth in Mice: Enhanced Efficacy by Its Formulation in Poly-(L)-lactic Acid-poly(ethylene Glycol) Nanoparticles International Journal of Oncology. Oct, 2017 | Pubmed ID: 28849098 Phospho-Aspirin (MDC-22) Prevents Pancreatic Carcinogenesis in Mice Cancer Prevention Research (Philadelphia, Pa.). Jul, 2016 | Pubmed ID: 27138793 The Novel Agent Phospho-glycerol-ibuprofen-amide (MDC-330) Inhibits Glioblastoma Growth in Mice: an Effect Mediated by Cyclin D1 Carcinogenesis. Apr, 2016 | Pubmed ID: 26905586 NSAIDs and Colorectal Cancer Control: Promise and Challenges Current Pharmacology Reports. Oct, 2015 | Pubmed ID: 26688785 Altered Interactions Between the Gut Microbiome and Colonic Mucosa Precede Polyposis in APCMin/+ Mice PloS One. 2015 | Pubmed ID: 26121046 The Evolving Role of Nonsteroidal Anti-inflammatory Drugs in Colon Cancer Prevention: a Cause for Optimism The Journal of Pharmacology and Experimental Therapeutics. Apr, 2015 | Pubmed ID: 25589413 Repurposing the Antipsychotic Trifluoperazine As an Antimetastasis Agent Molecular Pharmacology. 2015 | Pubmed ID: 25552486 Phospho-NSAIDs Have Enhanced Efficacy in Mice Lacking Plasma Carboxylesterase: Implications for Their Clinical Pharmacology Pharmaceutical Research. May, 2015 | Pubmed ID: 25392229 Phospho-aspirin-2 (MDC-22) Inhibits Estrogen Receptor Positive Breast Cancer Growth Both in Vitro and in Vivo by a Redox-dependent Effect PloS One. 2014 | Pubmed ID: 25369051 A Novel Ibuprofen Derivative with Anti-lung Cancer Properties: Synthesis, Formulation, Pharmacokinetic and Efficacy Studies International Journal of Pharmaceutics. Dec, 2014 | Pubmed ID: 25311177 Pegylation Improves the Pharmacokinetics and Bioavailability of Small-molecule Drugs Hydrolyzable by Esterases: a Study of Phospho-Ibuprofen The Journal of Pharmacology and Experimental Therapeutics. Oct, 2014 | Pubmed ID: 25047517 The in Vitro Metabolism of Phospho-sulindac Amide, a Novel Potential Anticancer Agent Biochemical Pharmacology. Sep, 2014 | Pubmed ID: 25044307 Phospho-aspirin (MDC-22) Inhibits Breast Cancer in Preclinical Animal Models: an Effect Mediated by EGFR Inhibition, P53 Acetylation and Oxidative Stress BMC Cancer. Feb, 2014 | Pubmed ID: 24575839 Phospho-sulindac Inhibits Pancreatic Cancer Growth: NFATc1 As a Drug Resistance Candidate International Journal of Oncology. Feb, 2014 | Pubmed ID: 24284479 A Novel Ras Inhibitor (MDC-1016) Reduces Human Pancreatic Tumor Growth in Mice Neoplasia (New York, N.Y.). Oct, 2013 | Pubmed ID: 24204197 Curcumin Enhances the Lung Cancer Chemopreventive Efficacy of Phospho-sulindac by Improving Its Pharmacokinetics International Journal of Oncology. Sep, 2013 | Pubmed ID: 23807084 Targeting Mitochondrial STAT3 with the Novel Phospho-valproic Acid (MDC-1112) Inhibits Pancreatic Cancer Growth in Mice PloS One. 2013 | Pubmed ID: 23650499 Aerosol Administration of Phospho-sulindac Inhibits Lung Tumorigenesis Molecular Cancer Therapeutics. Aug, 2013 | Pubmed ID: 23645590 Topically Applied Phospho-sulindac Hydrogel is Efficacious and Safe in the Treatment of Experimental Arthritis in Rats Pharmaceutical Research. Jun, 2013 | Pubmed ID: 23483440 Comparative in Vitro Metabolism of Phospho-tyrosol-indomethacin by Mice, Rats and Humans Biochemical Pharmacology. Apr, 2013 | Pubmed ID: 23399640 The Anticancer Effect of Phospho-tyrosol-indomethacin (MPI-621), a Novel Phosphoderivative of Indomethacin: in Vitro and in Vivo Studies Carcinogenesis. Apr, 2013 | Pubmed ID: 23338686 Platinum Folate Nanoparticles Toxicity: Cancer Vs. Normal Cells Toxicology in Vitro : an International Journal Published in Association with BIBRA. Mar, 2013 | Pubmed ID: 23318730 Nanodelivery Strategies in Cancer Chemotherapy: Biological Rationale and Pharmaceutical Perspectives Nanomedicine (London, England). Oct, 2012 | Pubmed ID: 23148540 MC-12, an Annexin A1-based Peptide, is Effective in the Treatment of Experimental Colitis PloS One. 2012 | Pubmed ID: 22844504 Topical Phospho-sulindac (OXT-328) is Effective in the Treatment of Non-melanoma Skin Cancer International Journal of Oncology. Oct, 2012 | Pubmed ID: 22842609 In Vitro and in Vivo Metabolic Studies of Phospho-aspirin (MDC-22) Pharmaceutical Research. Dec, 2012 | Pubmed ID: 22782648 Phospho-sulindac (OXT-328) Inhibits the Growth of Human Lung Cancer Xenografts in Mice: Enhanced Efficacy and Mitochondria Targeting by Its Formulation in Solid Lipid Nanoparticles Pharmaceutical Research. Nov, 2012 | Pubmed ID: 22723123 Phosphosulindac (OXT-328) Selectively Targets Breast Cancer Stem Cells in Vitro and in Human Breast Cancer Xenografts Stem Cells (Dayton, Ohio). Oct, 2012 | Pubmed ID: 22653497 Regioselective Oxidation of Phospho-NSAIDs by Human Cytochrome P450 and Flavin Monooxygenase Isoforms: Implications for Their Pharmacokinetic Properties and Safety British Journal of Pharmacology. Sep, 2012 | Pubmed ID: 22489789 Preclinical Predictors of Anticancer Drug Efficacy: Critical Assessment with Emphasis on Whether Nanomolar Potency Should Be Required of Candidate Agents The Journal of Pharmacology and Experimental Therapeutics. Jun, 2012 | Pubmed ID: 22448039 Phospho-ibuprofen (MDC-917) Suppresses Breast Cancer Growth: an Effect Controlled by the Thioredoxin System Breast Cancer Research : BCR. Jan, 2012 | Pubmed ID: 22293394 Carboxylesterases 1 and 2 Hydrolyze Phospho-nonsteroidal Anti-inflammatory Drugs: Relevance to Their Pharmacological Activity The Journal of Pharmacology and Experimental Therapeutics. Feb, 2012 | Pubmed ID: 22085648 Sterically Stabilized Liposomes Incorporating the Novel Anticancer Agent Phospho-ibuprofen (MDC-917): Preparation, Characterization, and in Vitro/in Vivo Evaluation Pharmaceutical Research. Jun, 2012 | Pubmed ID: 22072052 Chemotherapeutic Properties of Phospho-nonsteroidal Anti-inflammatory Drugs, a New Class of Anticancer Compounds Cancer Research. Dec, 2011 | Pubmed ID: 22025561 Structure-activity Relationship Study of Novel Anticancer Aspirin-based Compounds Molecular Medicine Reports. Sep-Oct, 2011 | Pubmed ID: 21805049 Oxidative Stress Mediates Through Apoptosis the Anticancer Effect of Phospho-nonsteroidal Anti-inflammatory Drugs: Implications for the Role of Oxidative Stress in the Action of Anticancer Agents The Journal of Pharmacology and Experimental Therapeutics. Sep, 2011 | Pubmed ID: 21646387 Phospho-sulindac (OXT-328) Combined with Difluoromethylornithine Prevents Colon Cancer in Mice Cancer Prevention Research (Philadelphia, Pa.). Jul, 2011 | Pubmed ID: 21464038 Phospho-ibuprofen (MDC-917) is a Novel Agent Against Colon Cancer: Efficacy, Metabolism, and Pharmacokinetics in Mouse Models The Journal of Pharmacology and Experimental Therapeutics. Jun, 2011 | Pubmed ID: 21422165 Protein Nitration and Nitrosylation by NO-donating Aspirin in Colon Cancer Cells: Relevance to Its Mechanism of Action Experimental Cell Research. Jun, 2011 | Pubmed ID: 21406194 Phospho-sulindac (OXT-922) Inhibits the Growth of Human Colon Cancer Cell Lines: a Redox/polyamine-dependent Effect Carcinogenesis. Nov, 2010 | Pubmed ID: 20627873 Phospho-sulindac (OXT-328), a Novel Sulindac Derivative, is Safe and Effective in Colon Cancer Prevention in Mice Gastroenterology. Oct, 2010 | Pubmed ID: 20600034 Annexin 1 Induced by Anti-inflammatory Drugs Binds to NF-kappaB and Inhibits Its Activation: Anticancer Effects in Vitro and in Vivo Cancer Research. Mar, 2010 | Pubmed ID: 20215502 The Differential Cell Signaling Effects of Two Positional Isomers of the Anticancer NO-donating Aspirin International Journal of Oncology. Oct, 2009 | Pubmed ID: 19724920 Regulation of Peroxisome Proliferator-activated Receptor-beta/delta by the APC/beta-CATENIN Pathway and Nonsteroidal Antiinflammatory Drugs Molecular Carcinogenesis. Oct, 2009 | Pubmed ID: 19415698 Phosphoaspirin (MDC-43), a Novel Benzyl Ester of Aspirin, Inhibits the Growth of Human Cancer Cell Lines More Potently Than Aspirin: a Redox-dependent Effect Carcinogenesis. Mar, 2009 | Pubmed ID: 19136474 Chemopreventive Agents Induce Oxidative Stress in Cancer Cells Leading to COX-2 Overexpression and COX-2-independent Cell Death Carcinogenesis. Jan, 2009 | Pubmed ID: 18952595 Nitric Oxide-donating Aspirin Inhibits the Growth of Pancreatic Cancer Cells Through Redox-dependent Signaling Cancer Letters. Jan, 2009 | Pubmed ID: 18805632 Food Components, Alternative Medicine, and Cancer: Progress and Promise Nutrition and Cancer. 2008 | Pubmed ID: 19003574 The Thioredoxin System Mediates Redox-induced Cell Death in Human Colon Cancer Cells: Implications for the Mechanism of Action of Anticancer Agents Cancer Research. Oct, 2008 | Pubmed ID: 18922898 Pharmacokinetic and Pharmacodynamic Study of NO-donating Aspirin in F344 Rats International Journal of Oncology. Oct, 2008 | Pubmed ID: 18813794 NO-donating Aspirin Inhibits Angiogenesis by Suppressing VEGF Expression in HT-29 Human Colon Cancer Mouse Xenografts Carcinogenesis. Sep, 2008 | Pubmed ID: 18544566 NO-Donating NSAIDs, PPARdelta, and Cancer: Does PPARdelta Contribute to Colon Carcinogenesis? PPAR Research. 2008 | Pubmed ID: 18528523 A Potentiometric Protein Sensor Built with Surface Molecular Imprinting Method Biosensors & Bioelectronics. Sep, 2008 | Pubmed ID: 18514502 NO-donating NSAIDs and Cancer: an Overview with a Note on Whether NO is Required for Their Action Nitric Oxide : Biology and Chemistry. Sep, 2008 | Pubmed ID: 18486630 The Novel Phenylester Anticancer Compounds: Study of a Derivative of Aspirin (phoshoaspirin) International Journal of Oncology. Jan, 2008 | Pubmed ID: 18097547 Development of Novel Agents Based on Nitric Oxide for the Control of Colon Cancer Acta Pharmacologica Sinica. Sep, 2007 | Pubmed ID: 17723176 The Use of Nitric Oxide-donating Nonsteroidal Anti-inflammatory Drugs in the Chemoprevention of Colorectal Neoplasia Current Opinion in Gastroenterology. Jan, 2007 | Pubmed ID: 17133086 Nitric Oxide-donating Aspirin Induces Apoptosis in Human Colon Cancer Cells Through Induction of Oxidative Stress Proceedings of the National Academy of Sciences of the United States of America. Nov, 2005 | Pubmed ID: 16282376 जलीय-कमी सूखी आंख रोग का एक खरगोश मॉडल Concanavalin द्वारा प्रेरित Lacrimal ग्रंथियों में एक इंजेक्शन: दवा प्रभावकारिता अध्ययन के लिए आवेदन Robert A. Honkanen1, Liqun Huang2,3, Basil Rigas2 1Department of Ophthalmology, Stony Brook University, 2Department of Preventive Medicine, Stony Brook University, 3Medicon Pharmaceuticals, Inc. JoVE 59631 Medicine खरगोशों में पूर्ण Dacryoadenectomy का उपयोग कर एक गंभीर सूखी आंख मॉडल की स्थापना Robert A. Honkanen1, Liqun Huang2,3, Wei Huang1, Basil Rigas2,4 1Department of Ophthalmology, Stony Brook University, 2Department of Medicine, Stony Brook University, 3Medicon Pharmaceuticals, Inc, 4Department of Preventive Medicine, Stony Brook University JoVE 60126 Medicine
जलीय-कमी सूखी आंख रोग का एक खरगोश मॉडल Concanavalin द्वारा प्रेरित Lacrimal ग्रंथियों में एक इंजेक्शन: दवा प्रभावकारिता अध्ययन के लिए आवेदन Robert A. Honkanen1, Liqun Huang2,3, Basil Rigas2 1Department of Ophthalmology, Stony Brook University, 2Department of Preventive Medicine, Stony Brook University, 3Medicon Pharmaceuticals, Inc. JoVE 59631 Medicine
खरगोशों में पूर्ण Dacryoadenectomy का उपयोग कर एक गंभीर सूखी आंख मॉडल की स्थापना Robert A. Honkanen1, Liqun Huang2,3, Wei Huang1, Basil Rigas2,4 1Department of Ophthalmology, Stony Brook University, 2Department of Medicine, Stony Brook University, 3Medicon Pharmaceuticals, Inc, 4Department of Preventive Medicine, Stony Brook University JoVE 60126 Medicine
