Constantin Radu Automation & Logistics Management, Screening Sciences & Novel Assay Technologies Institut Pasteur Korea Biography Publications Institution JoVE Articles Constantin Radu has not added a biography. If you are Constantin Radu and would like to personalize this page please email our Author Liaison for assistance. Publications Evaluation of Compound Optical Interference in High-Content Screening SLAS Discovery. Apr, 2017 | Pubmed ID: 28467117 High-Content Screening of Raw Actinomycete Extracts for the Identification of Antituberculosis Activities SLAS Discovery. Feb, 2017 | Pubmed ID: 27810952 Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors Cancer Research. Aug, 2016 | Pubmed ID: 27256563 Small-molecule Inhibitors of SETD8 with Cellular Activity ACS Chemical Biology. Nov, 2014 | Pubmed ID: 25137013 A 1536-well Fluorescence Polarization Assay to Screen for Modulators of the MUSASHI Family of RNA-binding Proteins Combinatorial Chemistry & High Throughput Screening. 2014 | Pubmed ID: 24912481 Chemical & RNAi Screening at MSKCC: a Collaborative Platform to Discover & Repurpose Drugs to Fight Disease Combinatorial Chemistry & High Throughput Screening. May, 2014 | Pubmed ID: 24661215 Inhibition of Dengue Virus Replication by a Class of Small-molecule Compounds That Antagonize Dopamine Receptor D4 and Downstream Mitogen-activated Protein Kinase Signaling Journal of Virology. May, 2014 | Pubmed ID: 24599995 A High-content Assay Strategy for the Identification and Profiling of ABCG2 Modulators in Live Cells Assay and Drug Development Technologies. Jan-Feb, 2014 | Pubmed ID: 23992118 Flaviviruses Are Sensitive to Inhibition of Thymidine Synthesis Pathways Journal of Virology. Sep, 2013 | Pubmed ID: 23824813 A Novel High Throughput 1536-well Notch1 γ -secretase AlphaLISA Assay Combinatorial Chemistry & High Throughput Screening. Jul, 2013 | Pubmed ID: 23448293 An Arrayed Genome-scale Lentiviral-enabled Short Hairpin RNA Screen Identifies Lethal and Rescuer Gene Candidates Assay and Drug Development Technologies. Apr, 2013 | Pubmed ID: 23198867 An Arrayed RNA Interference Genome-wide Screen Identifies Candidate Genes Involved in the MicroRNA 21 Biogenesis Pathway Assay and Drug Development Technologies. Apr, 2013 | Pubmed ID: 23153064 Large-scale Screening Using Familial Dysautonomia Induced Pluripotent Stem Cells Identifies Compounds That Rescue IKBKAP Expression Nature Biotechnology. Dec, 2012 | Pubmed ID: 23159879 Designs and Concept Reliance of a Fully Automated High-content Screening Platform Journal of Laboratory Automation. Oct, 2012 | Pubmed ID: 22797489 An Image-based Biosensor Assay Strategy to Screen for Modulators of the MicroRNA 21 Biogenesis Pathway Combinatorial Chemistry & High Throughput Screening. Aug, 2012 | Pubmed ID: 22540737 A High Throughput Scintillation Proximity Imaging Assay for Protein Methyltransferases Combinatorial Chemistry & High Throughput Screening. Jun, 2012 | Pubmed ID: 22256970 Comparison of Luminescence ADP Production Assay and Radiometric Scintillation Proximity Assay for Cdc7 Kinase Combinatorial Chemistry & High Throughput Screening. Sep, 2011 | Pubmed ID: 21564015 High-content Assay to Identify Inhibitors of Dengue Virus Infection Assay and Drug Development Technologies. Oct, 2010 | Pubmed ID: 20973722 Live-cell Imaging of Caspase Activation for High-content Screening Journal of Biomolecular Screening. Sep, 2009 | Pubmed ID: 19726787 A Miniaturized 1536-well Format Gamma-secretase Assay Assay and Drug Development Technologies. Oct, 2009 | Pubmed ID: 19715456 Development and Validation of a High-density Fluorescence Polarization-based Assay for the Trypanosoma RNA Triphosphatase TbCet1 Combinatorial Chemistry & High Throughput Screening. Mar, 2009 | Pubmed ID: 19275531 Revisiting Old Drugs As Novel Agents for Retinoblastoma: in Vitro and in Vivo Antitumor Activity of Cardenolides Investigative Ophthalmology & Visual Science. Jul, 2009 | Pubmed ID: 19151399 A High Density Assay Format for the Detection of Novel Cytotoxic Agents in Large Chemical Libraries Journal of Enzyme Inhibition and Medicinal Chemistry. Dec, 2008 | Pubmed ID: 18608772 A Profiling Platform for the Identification of Selective Metalloprotease Inhibitors Journal of Biomolecular Screening. Apr, 2008 | Pubmed ID: 18349423 Synthesis, Antileukemic and Antiplatelet Activities of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines European Journal of Medicinal Chemistry. Sep, 2008 | Pubmed ID: 18191304 Synthesis and Antiproliferative Activity of Some Diaryldiazepines and Diarylpyrimidines Journal of Enzyme Inhibition and Medicinal Chemistry. Dec, 2007 | Pubmed ID: 18237024 Assay Development for High Content Quantification of Sod1 Mutant Protein Aggregate Formation in Living Cells Honggun Lee1, Constantin Radu1, Jeung Whan Han2, Regis Grailhe3 1Automation & Logistics Management, Screening Sciences & Novel Assay Technologies, Institut Pasteur Korea, 2School of Pharmacy, Sungkyunkwan University, 3Technology Development Platform, Institut Pasteur Korea JoVE 56425 Neuroscience
Assay Development for High Content Quantification of Sod1 Mutant Protein Aggregate Formation in Living Cells Honggun Lee1, Constantin Radu1, Jeung Whan Han2, Regis Grailhe3 1Automation & Logistics Management, Screening Sciences & Novel Assay Technologies, Institut Pasteur Korea, 2School of Pharmacy, Sungkyunkwan University, 3Technology Development Platform, Institut Pasteur Korea JoVE 56425 Neuroscience