Darrell N. Kotton Center for Regenerative Medicine Boston University and Boston Medical Center Biography Publications Institution JoVE Articles Darrell N. Kotton has not added a biography. If you are Darrell N. Kotton and would like to personalize this page please email our Author Liaison for assistance. Publications Human Distal Airways Contain a Multipotent Secretory Cell That Can Regenerate Alveoli Nature. Apr, 2022 | Pubmed ID: 35355013 Editorial: Progenitors and Stem Cells in Thyroid Development, Disease, and Regeneration Frontiers in Endocrinology. 2022 | Pubmed ID: 35211095 Patient-specific IPSCs Carrying an SFTPC Mutation Reveal the Intrinsic Alveolar Epithelial Dysfunction at the Inception of Interstitial Lung Disease Cell Reports. Aug, 2021 | Pubmed ID: 34469722 Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19 Proceedings of the National Academy of Sciences of the United States of America. 09, 2021 | Pubmed ID: 34413211 Differentiation of Human Pluripotent Stem Cells into Functional Airway Basal Stem Cells STAR Protocols. 09, 2021 | Pubmed ID: 34355203 Derivation of Thyroid Follicular Cells From Pluripotent Stem Cells: Insights From Development and Implications for Regenerative Medicine Frontiers in Endocrinology. 2021 | Pubmed ID: 33959101 Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells Cell Stem Cell. 01, 2021 | Pubmed ID: 33098807 Epithelial Stem and Progenitor Cells in Lung Repair and Regeneration Annual Review of Physiology. 02, 2021 | Pubmed ID: 33074772 Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 Molecular Cell. 12, 2020 | Pubmed ID: 33259812 SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response Cell Stem Cell. 12, 2020 | Pubmed ID: 32979316 Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells Cell Stem Cell. 10, 2020 | Pubmed ID: 32891189 The in Vivo Genetic Program of Murine Primordial Lung Epithelial Progenitors Nature Communications. 01, 2020 | Pubmed ID: 32005814 Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows During Differentiation of Human PSC-Derived Distal Lung Progenitors Cell Stem Cell. 04, 2020 | Pubmed ID: 32004478 Derivation of Self-renewing Lung Alveolar Epithelial Type II Cells from Human Pluripotent Stem Cells Nature Protocols. 12, 2019 | Pubmed ID: 31732721 Generation of a Purified IPSC-Derived Smooth Muscle-like Population For Cell Sheet Engineering Stem Cell Reports. 09, 2019 | Pubmed ID: 31422908 Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity Journal of Immunology (Baltimore, Md. : 1950). 04, 2019 | Pubmed ID: 30796179 Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium Stem Cell Reports. 05, 2018 | Pubmed ID: 29657097 Claudin-18: Unexpected Regulator of Lung Alveolar Epithelial Cell Proliferation The Journal of Clinical Investigation. 03, 2018 | Pubmed ID: 29400691 Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells Cell Stem Cell. 10, 2017 | Pubmed ID: 28965766 Pluripotent Stem Cell Differentiation Reveals Distinct Developmental Pathways Regulating Lung- Versus Thyroid-lineage Specification Development (Cambridge, England). 11, 2017 | Pubmed ID: 28947536 Vascular Smooth Muscle Cells Derived from Inbred Swine Induced Pluripotent Stem Cells for Vascular Tissue Engineering Biomaterials. Dec, 2017 | Pubmed ID: 28942128 Prospective Isolation of NKX2-1-expressing Human Lung Progenitors Derived from Pluripotent Stem Cells The Journal of Clinical Investigation. Jun, 2017 | Pubmed ID: 28463226 Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells Via Temporal Regulation of Wnt Signaling Cell Stem Cell. 06, 2017 | Pubmed ID: 28366587 Regenerative Therapy for Hypothyroidism: Mechanisms and Possibilities Molecular and Cellular Endocrinology. 04, 2017 | Pubmed ID: 27876515 Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells Cell Stem Cell. Nov, 2015 | Pubmed ID: 26593959 Emergence of a Stage-dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-deficient IPS Cells Stem Cell Reports. May, 2015 | Pubmed ID: 25843048 Embryonic and Induced Pluripotent Stem Cells for Lung Regeneration Annals of the American Thoracic Society. Mar, 2015 | Pubmed ID: 25830836 Targeted Correction and Restored Function of the CFTR Gene in Cystic Fibrosis Induced Pluripotent Stem Cells Stem Cell Reports. Apr, 2015 | Pubmed ID: 25772471 Derivation of Endodermal Progenitors From Pluripotent Stem Cells Journal of Cellular Physiology. Feb, 2015 | Pubmed ID: 25160562 Lung Regeneration: Mechanisms, Applications and Emerging Stem Cell Populations Nature Medicine. Aug, 2014 | Pubmed ID: 25100528 KDR Identifies a Conserved Human and Murine Hepatic Progenitor and Instructs Early Liver Development Cell Stem Cell. Jun, 2013 | Pubmed ID: 23746980 The Aryl Hydrocarbon Receptor Directs Hematopoietic Progenitor Cell Expansion and Differentiation Blood. Jul, 2013 | Pubmed ID: 23723449 Lentiviral Delivery of RNAi for in Vivo Lineage-specific Modulation of Gene Expression in Mouse Lung Macrophages Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2013 | Pubmed ID: 23403494 Induced Pluripotent Stem Cells Used to Reveal Drug Actions in a Long QT Syndrome Family with Complex Genetics The Journal of General Physiology. Jan, 2013 | Pubmed ID: 23277474 Mouse ESC Differentiation to Nkx2.1+ Lung and Thyroid Progenitors Bio-protocol. Nov, 2012 | Pubmed ID: 27453901 The 2012 Nobel Prize in Physiology or Medicine: Democratizing Pluripotency for Lung Researchers American Journal of Respiratory and Critical Care Medicine. Dec, 2012 | Pubmed ID: 23204376 The Transcription Factors Grainyhead-like 2 and NK2-Homeobox 1 Form a Regulatory Loop That Coordinates Lung Epithelial Cell Morphogenesis and Differentiation The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22955271 Modeling Supravalvular Aortic Stenosis Syndrome with Human Induced Pluripotent Stem Cells Circulation. Oct, 2012 | Pubmed ID: 22914687 Next-generation Regeneration: the Hope and Hype of Lung Stem Cell Research American Journal of Respiratory and Critical Care Medicine. Jun, 2012 | Pubmed ID: 22517787 Efficient Derivation of Purified Lung and Thyroid Progenitors from Embryonic Stem Cells Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482505 Self-renewing Endodermal Progenitor Lines Generated from Human Pluripotent Stem Cells Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482503 Maintenance and Repair of the Lung Endothelium Does Not Involve Contributions from Marrow-derived Endothelial Precursor Cells American Journal of Respiratory Cell and Molecular Biology. Jul, 2012 | Pubmed ID: 22323363 Case Records of the Massachusetts General Hospital. Case 2-2012. A 63-year-old Woman with Dyspnea and Rapidly Progressive Respiratory Failure The New England Journal of Medicine. Jan, 2012 | Pubmed ID: 22256809 Are Embryonic Stem and Induced Pluripotent Stem Cells the Same or Different? Implications for Their Potential Therapeutic Use Cell Cycle (Georgetown, Tex.). Jan, 2012 | Pubmed ID: 22186787 Role of Nanog in the Maintenance of Marrow Stromal Stem Cells During Post Natal Bone Regeneration Biochemical and Biophysical Research Communications. Jan, 2012 | Pubmed ID: 22142851 Biophysical Properties of Slow Potassium Channels in Human Embryonic Stem Cell Derived Cardiomyocytes Implicate Subunit Stoichiometry The Journal of Physiology. Dec, 2011 | Pubmed ID: 22025662 Programmatic Change: Lung Disease Research in the Era of Induced Pluripotency American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2011 | Pubmed ID: 21984571 A Shift from Cell Cultures to Creatures: in Vivo Imaging of Small Animals in Experimental Regenerative Medicine Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2011 | Pubmed ID: 21952170 Cell Plasticity in Lung Injury and Repair: Report from an NHLBI Workshop, April 19-20, 2010 Proceedings of the American Thoracic Society. Jun, 2011 | Pubmed ID: 21653526 Mouse ES and IPS Cells Can Form Similar Definitive Endoderm Despite Differences in Imprinted Genes The Journal of Clinical Investigation. Jun, 2011 | Pubmed ID: 21537085 FOXO1 Modulates Osteoblast Differentiation Bone. May, 2011 | Pubmed ID: 21281751 Generation of Transgene-free Lung Disease-specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette Stem Cells (Dayton, Ohio). Oct, 2010 | Pubmed ID: 20715179 The Role of Skin-derived Dendritic Cells in CD8+ T Cell Priming Following Immunization with Lentivectors Journal of Immunology (Baltimore, Md. : 1950). May, 2010 | Pubmed ID: 20357252 Amelioration of Emphysema in Mice Through Lentiviral Transduction of Long-lived Pulmonary Alveolar Macrophages The Journal of Clinical Investigation. Jan, 2010 | Pubmed ID: 20038801 Excision of Reprogramming Transgenes Improves the Differentiation Potential of IPS Cells Generated with a Single Excisable Vector Stem Cells (Dayton, Ohio). Jan, 2010 | Pubmed ID: 19904830 Pulmonary Alveolar Proteinosis: a Bench-to-bedside Story of Granulocyte-macrophage Colony-stimulating Factor Dysfunction Chest. Aug, 2009 | Pubmed ID: 19666756 Transcriptional Analysis of Fracture Healing and the Induction of Embryonic Stem Cell-related Genes PloS One. 2009 | Pubmed ID: 19415118 Induced Pluripotent Stem Cell Generation Using a Single Lentiviral Stem Cell Cassette Stem Cells (Dayton, Ohio). Mar, 2009 | Pubmed ID: 19096035 Sustained Expression of Alpha1-antitrypsin After Transplantation of Manipulated Hematopoietic Stem Cells American Journal of Respiratory Cell and Molecular Biology. Aug, 2008 | Pubmed ID: 18323534 Another Notch in Stem Cell Biology: Drosophila Intestinal Stem Cells and the Specification of Cell Fates BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Feb, 2008 | Pubmed ID: 18200564 The Prolonged Life-span of Alveolar Macrophages American Journal of Respiratory Cell and Molecular Biology. Apr, 2008 | Pubmed ID: 18192503 Dual-promoter Lentiviral System Allows Inducible Expression of Noxious Proteins in Macrophages Journal of Immunological Methods. Jan, 2008 | Pubmed ID: 17967462 Lung Stem Cells Cell and Tissue Research. Jan, 2008 | Pubmed ID: 17805578 Exogenous Control of Mammalian Gene Expression Via Modulation of Translational Termination Nature Medicine. Sep, 2006 | Pubmed ID: 16892063 Failure of Bone Marrow to Reconstitute Lung Epithelium American Journal of Respiratory Cell and Molecular Biology. Oct, 2005 | Pubmed ID: 15961722 Efficiency of Transduction of Highly Purified Murine Hematopoietic Stem Cells by Lentiviral and Oncoretroviral Vectors Under Conditions of Minimal in Vitro Manipulation Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2005 | Pubmed ID: 15922964 A Novel Stem-cell Population in Adult Liver with Potent Hematopoietic-reconstitution Activity Blood. Sep, 2005 | Pubmed ID: 15870171 Embryonic Lung Side Population Cells Are Hematopoietic and Vascular Precursors American Journal of Respiratory Cell and Molecular Biology. Jul, 2005 | Pubmed ID: 15802552 Lung Stem Cells: New Paradigms Experimental Hematology. Apr, 2004 | Pubmed ID: 15050743 Translational Physiology: Origin and Phenotype of Lung Side Population Cells American Journal of Physiology. Lung Cellular and Molecular Physiology. Sep, 2004 | Pubmed ID: 15047566 Side Population Cells and Bcrp1 Expression in Lung American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2003 | Pubmed ID: 12626330 Stem Cell Antigen-1 Expression in the Pulmonary Vascular Endothelium American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2003 | Pubmed ID: 12611818 Generating 3D Spheres and 2D Air-Liquid Interface Cultures of Human Induced Pluripotent Stem Cell-Derived Type 2 Alveolar Epithelial Cells Rhiannon B. Werder*1,2,3, Jessie Huang*1,2, Kristine M. Abo1,2, Olivia T. Hix1,2, Kasey Minakin1,2, Konstantinos-Dionysios Alysandratos1,2, Carly Merritt1,2, Kayleigh Berthiaume1,2, Andrea B. Alber1,2, Claire L. Burgess1,2, Darrell N. Kotton*1,2, Andrew A. Wilson*1,2 1Center for Regenerative Medicine, Boston University and Boston Medical Center, 2The Pulmonary Center and Department of Medicine, Boston University School of Medicine, 3QIMR Berghofer Medical Research Institute JoVE 63875 Developmental Biology Generation of Human Induced Pluripotent Stem Cells from Peripheral Blood Using the STEMCCA Lentiviral Vector Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology
Generating 3D Spheres and 2D Air-Liquid Interface Cultures of Human Induced Pluripotent Stem Cell-Derived Type 2 Alveolar Epithelial Cells Rhiannon B. Werder*1,2,3, Jessie Huang*1,2, Kristine M. Abo1,2, Olivia T. Hix1,2, Kasey Minakin1,2, Konstantinos-Dionysios Alysandratos1,2, Carly Merritt1,2, Kayleigh Berthiaume1,2, Andrea B. Alber1,2, Claire L. Burgess1,2, Darrell N. Kotton*1,2, Andrew A. Wilson*1,2 1Center for Regenerative Medicine, Boston University and Boston Medical Center, 2The Pulmonary Center and Department of Medicine, Boston University School of Medicine, 3QIMR Berghofer Medical Research Institute JoVE 63875 Developmental Biology
Generation of Human Induced Pluripotent Stem Cells from Peripheral Blood Using the STEMCCA Lentiviral Vector Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology
