Ferry Ossendorp Department of Immunohematology and Blood Transfusion Leiden University Medical Center Biography Publications Institution JoVE Articles Ferry Ossendorp has not added a biography. If you are Ferry Ossendorp and would like to personalize this page please email our Author Liaison for assistance. Publications Cationic Synthetic Long Peptides-loaded Nanogels: An Efficient Therapeutic Vaccine Formulation for Induction of T-cell Responses Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2019 | Pubmed ID: 31672626 A Poly-neoantigen DNA Vaccine Synergizes with PD-1 Blockade to Induce T Cell-mediated Tumor Control Oncoimmunology. 2019 | Pubmed ID: 31646082 Effective Chemoimmunotherapy by Co-delivery of Doxorubicin and Immune Adjuvants in Biodegradable Nanoparticles Theranostics. 2019 | Pubmed ID: 31588231 PD-L1 Blockade Engages Tumor-infiltrating Lymphocytes to Co-express Targetable Activating and Inhibitory Receptors Journal for Immunotherapy of Cancer. Aug, 2019 | Pubmed ID: 31412943 Combined Inhibition of TGF-β Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models Cells. 04, 2019 | Pubmed ID: 30959852 Peptides Conjugated to 2-alkoxy-8-oxo-adenine As Potential Synthetic Vaccines Triggering TLR7 Bioorganic & Medicinal Chemistry Letters. Jun, 2019 | Pubmed ID: 30952595 Dual Synthetic Peptide Conjugate Vaccine Simultaneously Triggers TLR2 and NOD2 and Activates Human Dendritic Cells Bioconjugate Chemistry. Apr, 2019 | Pubmed ID: 30865430 FcγR Interaction is Not Required for Effective Anti-PD-L1 Immunotherapy but Can Add Additional Benefit Depending on the Tumor Model International Journal of Cancer. 01, 2019 | Pubmed ID: 30259976 A Dual-Color Bioluminescence Reporter Mouse for Simultaneous Imaging of T Cell Localization and Function Frontiers in Immunology. 2018 | Pubmed ID: 30671062 Novel TLR2-binding Adjuvant Induces Enhanced T Cell Responses and Tumor Eradication Journal for Immunotherapy of Cancer. 12, 2018 | Pubmed ID: 30541631 Tumor-draining Lymph Nodes Are Pivotal in PD-1/PD-L1 Checkpoint Therapy JCI Insight. 12, 2018 | Pubmed ID: 30518694 : A Workflow for Visual and Quantitative Analysis of Flow and Mass Cytometry Data to Discover Immune Signatures and Correlations Computational and Structural Biotechnology Journal. 2018 | Pubmed ID: 30450167 High FcγR Expression on Intratumoral Macrophages Enhances Tumor-Targeting Antibody Therapy Journal of Immunology (Baltimore, Md. : 1950). 12, 2018 | Pubmed ID: 30397036 FcγRI Expression on Macrophages is Required for Antibody-mediated Tumor Protection by Cytomegalovirus-based Vaccines Oncotarget. Jun, 2018 | Pubmed ID: 30034625 Combinatory Therapy Adopting Nanoparticle-based Cancer Vaccination with Immune Checkpoint Blockade for Treatment of Post-surgical Tumor Recurrences Journal of Controlled Release : Official Journal of the Controlled Release Society. 09, 2018 | Pubmed ID: 30008371 Approaches to Improve Chemically Defined Synthetic Peptide Vaccines Frontiers in Immunology. 2018 | Pubmed ID: 29755468 Formation of Immune Complexes with a Tetanus-Derived B Cell Epitope Boosts Human T Cell Responses to Covalently Linked Peptides in an Ex Vivo Blood Loop System Journal of Immunology (Baltimore, Md. : 1950). 07, 2018 | Pubmed ID: 29752315 Chemical Control over T-Cell Activation in Vivo Using Deprotection of Trans-Cyclooctene-Modified Epitopes ACS Chemical Biology. 06, 2018 | Pubmed ID: 29733186 Sustained Cross-presentation Capacity of Murine Splenic Dendritic Cell Subsets in Vivo European Journal of Immunology. 07, 2018 | Pubmed ID: 29676785 A Restricted Role for FcγR in the Regulation of Adaptive Immunity Journal of Immunology (Baltimore, Md. : 1950). 04, 2018 | Pubmed ID: 29523656 Linking T Cell Epitopes to a Common Linear B Cell Epitope: A Targeting and Adjuvant Strategy to Improve T Cell Responses Molecular Immunology. 01, 2018 | Pubmed ID: 29175591 Photodynamic-Immune Checkpoint Therapy Eradicates Local and Distant Tumors by CD8 T Cells Cancer Immunology Research. 10, 2017 | Pubmed ID: 28851692 PD-L1 Immune Suppression in Cancer: Tumor Cells or Host Cells? Oncoimmunology. 2017 | Pubmed ID: 28811961 CD4 T Cell and NK Cell Interplay Key to Regression of MHC Class I Tumors Upon TLR7/8 Agonist Therapy Cancer Immunology Research. 08, 2017 | Pubmed ID: 28637878 PD-L1 Expression on Malignant Cells is No Prerequisite for Checkpoint Therapy Oncoimmunology. 2017 | Pubmed ID: 28507803 C1q-Dependent Dendritic Cell Cross-Presentation of In Vivo-Formed Antigen-Antibody Complexes Journal of Immunology (Baltimore, Md. : 1950). 06, 2017 | Pubmed ID: 28432146 Self-Assembling Peptide Epitopes As Novel Platform for Anticancer Vaccination Molecular Pharmaceutics. 05, 2017 | Pubmed ID: 28088862 Strong in Vivo Antitumor Responses Induced by an Antigen Immobilized in Nanogels Via Reducible Bonds Nanoscale. Dec, 2016 | Pubmed ID: 27748778 The Optimization of Bioorthogonal Epitope Ligation Within MHC-I Complexes ACS Chemical Biology. 11, 2016 | Pubmed ID: 27704768 TLR2 Ligand-synthetic Long Peptide Conjugates Effectively Stimulate Tumor-draining Lymph Node T Cells of Cervical Cancer Patients Oncotarget. Oct, 2016 | Pubmed ID: 27564262 Glycan Modification of Antigen Alters Its Intracellular Routing in Dendritic Cells, Promoting Priming of T Cells ELife. Mar, 2016 | Pubmed ID: 26999763 Vaccines for Established Cancer: Overcoming the Challenges Posed by Immune Evasion Nature Reviews. Cancer. Apr, 2016 | Pubmed ID: 26965076 TAP-independent Self-peptides Enhance T Cell Recognition of Immune-escaped Tumors The Journal of Clinical Investigation. Feb, 2016 | Pubmed ID: 26784543 Combination of Photodynamic Therapy and Specific Immunotherapy Efficiently Eradicates Established Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2016 | Pubmed ID: 26546617 The Viral Context Instructs the Redundancy of Costimulatory Pathways in Driving CD8(+) T Cell Expansion ELife. Aug, 2015 | Pubmed ID: 26263500 Therapeutic Cancer Vaccines The Journal of Clinical Investigation. Sep, 2015 | Pubmed ID: 26214521 Polymeric Microparticles for Sustained and Local Delivery of AntiCD40 and AntiCTLA-4 in Immunotherapy of Cancer Biomaterials. Aug, 2015 | Pubmed ID: 25993015 The Translocon Protein Sec61 Mediates Antigen Transport from Endosomes in the Cytosol for Cross-presentation to CD8(+) T Cells Immunity. May, 2015 | Pubmed ID: 25979419 Polymeric Nanoparticles for Co-delivery of Synthetic Long Peptide Antigen and Poly IC As Therapeutic Cancer Vaccine Formulation Journal of Controlled Release : Official Journal of the Controlled Release Society. Apr, 2015 | Pubmed ID: 25660830 Vaccine-induced Tumor Necrosis Factor-producing T Cells Synergize with Cisplatin to Promote Tumor Cell Death Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2015 | Pubmed ID: 25501579 CD40-targeted Dendritic Cell Delivery of PLGA-nanoparticle Vaccines Induce Potent Anti-tumor Responses Biomaterials. Feb, 2015 | Pubmed ID: 25465442 Near-infrared Labeled, Ovalbumin Loaded Polymeric Nanoparticles Based on a Hydrophilic Polyester As Model Vaccine: In Vivo Tracking and Evaluation of Antigen-specific CD8(+) T Cell Immune Response Biomaterials. Jan, 2015 | Pubmed ID: 25453974 Two in One: Improving Synthetic Long Peptide Vaccines by Combining Antigen and Adjuvant in One Molecule Oncoimmunology. 2014 | Pubmed ID: 25610736 FcRγ-chain ITAM Signaling is Critically Required for Cross-presentation of Soluble Antibody-antigen Complexes by Dendritic Cells Journal of Immunology (Baltimore, Md. : 1950). Dec, 2014 | Pubmed ID: 25355925 Enhanced Cross-presentation and Improved CD8+ T Cell Responses After Mannosylation of Synthetic Long Peptides in Mice PloS One. 2014 | Pubmed ID: 25137039 Targeting Nanoparticles to CD40, DEC-205 or CD11c Molecules on Dendritic Cells for Efficient CD8(+) T Cell Response: a Comparative Study Journal of Controlled Release : Official Journal of the Controlled Release Society. Oct, 2014 | Pubmed ID: 25068703 Dominant Contribution of the Proteasome and Metalloproteinases to TAP-independent MHC-I Peptide Repertoire Molecular Immunology. Nov, 2014 | Pubmed ID: 24983205 Ovalbumin-coated PH-sensitive Microneedle Arrays Effectively Induce Ovalbumin-specific Antibody and T-cell Responses in Mice European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. Oct, 2014 | Pubmed ID: 24820032 IgG-mediated Anaphylaxis to a Synthetic Long Peptide Vaccine Containing a B Cell Epitope Can Be Avoided by Slow-release Formulation Journal of Immunology (Baltimore, Md. : 1950). Jun, 2014 | Pubmed ID: 24813207 Effectiveness of Slow-release Systems in CD40 Agonistic Antibody Immunotherapy of Cancer Vaccine. Mar, 2014 | Pubmed ID: 24508038 Local Immunomodulation for Cancer Therapy: Providing Treatment Where Needed Oncoimmunology. Nov, 2013 | Pubmed ID: 24490127 New Role of Signal Peptide Peptidase to Liberate C-terminal Peptides for MHC Class I Presentation Journal of Immunology (Baltimore, Md. : 1950). Oct, 2013 | Pubmed ID: 24048903 Dendritic Cells Process Synthetic Long Peptides Better Than Whole Protein, Improving Antigen Presentation and T-cell Activation European Journal of Immunology. Oct, 2013 | Pubmed ID: 23836147 Controlled Local Delivery of CTLA-4 Blocking Antibody Induces CD8+ T-cell-dependent Tumor Eradication and Decreases Risk of Toxic Side Effects Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2013 | Pubmed ID: 23788581 Prospects of Combinatorial Synthetic Peptide Vaccine-based Immunotherapy Against Cancer Seminars in Immunology. Apr, 2013 | Pubmed ID: 23706598 Efficient Ex Vivo Induction of T Cells with Potent Anti-tumor Activity by Protein Antigen Encapsulated in Nanoparticles Cancer Immunology, Immunotherapy : CII. Jul, 2013 | Pubmed ID: 23613147 Vaccine-induced Effector-memory CD8+ T Cell Responses Predict Therapeutic Efficacy Against Tumors Journal of Immunology (Baltimore, Md. : 1950). Oct, 2012 | Pubmed ID: 22914049 Fcγ Receptor IIb Strongly Regulates Fcγ Receptor-facilitated T Cell Activation by Dendritic Cells Journal of Immunology (Baltimore, Md. : 1950). Jul, 2012 | Pubmed ID: 22649202 Circulating Specific Antibodies Enhance Systemic Cross-priming by Delivery of Complexed Antigen to Dendritic Cells in Vivo European Journal of Immunology. Mar, 2012 | Pubmed ID: 22488363 The Inhibiting Fc Receptor for IgG, FcγRIIB, is a Modifier of Autoimmune Susceptibility Journal of Immunology (Baltimore, Md. : 1950). Aug, 2011 | Pubmed ID: 21724994 Discovery of Low-affinity Preproinsulin Epitopes and Detection of Autoreactive CD8 T-cells Using Combinatorial MHC Multimers Journal of Autoimmunity. Nov, 2011 | Pubmed ID: 21636247 Improved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors PloS One. Feb, 2011 | Pubmed ID: 21347234 Antigen Processing by Nardilysin and Thimet Oligopeptidase Generates Cytotoxic T Cell Epitopes Nature Immunology. Jan, 2011 | Pubmed ID: 21151101 Activity-based Profiling Reveals Reactivity of the Murine Thymoproteasome-specific Subunit Beta5t Chemistry & Biology. Aug, 2010 | Pubmed ID: 20797608 Effective CD8(+) T Cell Priming and Tumor Protection by Enterotoxin B Subunit-conjugated Peptides Targeted to Dendritic Cells Vaccine. Aug, 2009 | Pubmed ID: 19576942 DC-induced CD8(+) T-cell Response is Inhibited by MHC Class II-dependent DX5(+)CD4(+) Treg European Journal of Immunology. Jul, 2009 | Pubmed ID: 19544486 Antigen Storage Compartments in Mature Dendritic Cells Facilitate Prolonged Cytotoxic T Lymphocyte Cross-priming Capacity Proceedings of the National Academy of Sciences of the United States of America. Apr, 2009 | Pubmed ID: 19346487 Steric Hindrance and Fast Dissociation Explain the Lack of Immunogenicity of the Minor Histocompatibility HA-1Arg Null Allele Journal of Immunology (Baltimore, Md. : 1950). Apr, 2009 | Pubmed ID: 19342659 A Novel Role of Complement Factor C1q in Augmenting the Presentation of Antigen Captured in Immune Complexes to CD8+ T Lymphocytes Journal of Immunology (Baltimore, Md. : 1950). Jun, 2007 | Pubmed ID: 17548593 Dendritic Cells, but Not Macrophages or B Cells, Activate Major Histocompatibility Complex Class II-restricted CD4+ T Cells Upon Immune-complex Uptake in Vivo Immunology. Dec, 2006 | Pubmed ID: 16995881 Immune Complex-loaded Dendritic Cells Are Superior to Soluble Immune Complexes As Antitumor Vaccine Journal of Immunology (Baltimore, Md. : 1950). Apr, 2006 | Pubmed ID: 16585547 Selective Cytotoxic T-lymphocyte Targeting of Tumor Immune Escape Variants Nature Medicine. Apr, 2006 | Pubmed ID: 16550190 Murine Fc Receptors for IgG Are Redundant in Facilitating Presentation of Immune Complex Derived Antigen to CD8+ T Cells in Vivo Molecular Immunology. May, 2006 | Pubmed ID: 16513171 Autoreactive CD8 T Cells Associated with Beta Cell Destruction in Type 1 Diabetes Proceedings of the National Academy of Sciences of the United States of America. Dec, 2005 | Pubmed ID: 16339897 Differential Expression Regulation of the Alpha and Beta Subunits of the PA28 Proteasome Activator in Mature Dendritic Cells Journal of Immunology (Baltimore, Md. : 1950). Jun, 2005 | Pubmed ID: 15944286 Gamma Irradiation or CD4+-T-cell Depletion Causes Reactivation of Latent Salmonella Enterica Serovar Typhimurium Infection in C3H/HeN Mice Infection and Immunity. May, 2005 | Pubmed ID: 15845491 New Chelation Strategy Allows for Quick and Clean 99mTc-labeling of Synthetic Peptides Nuclear Medicine and Biology. Aug, 2004 | Pubmed ID: 15246374 Prolongation of Skin Graft Survival by Modulation of the Alloimmune Response with Alternatively Activated Dendritic Cells Transplantation. Dec, 2003 | Pubmed ID: 14702533 The Minor Histocompatibility Antigen HA-3 Arises from Differential Proteasome-mediated Cleavage of the Lymphoid Blast Crisis (Lbc) Oncoprotein Blood. Jul, 2003 | Pubmed ID: 12663445 Effective Therapeutic Anticancer Vaccines Based on Precision Guiding of Cytolytic T Lymphocytes Immunological Reviews. Oct, 2002 | Pubmed ID: 12445291 Antitumor Efficacy of Wild-type P53-specific CD4(+) T-helper Cells Cancer Research. Nov, 2002 | Pubmed ID: 12414646 Identification of a Novel HLA-B60-restricted T Cell Epitope of the Minor Histocompatibility Antigen HA-1 Locus Journal of Immunology (Baltimore, Md. : 1950). Sep, 2002 | Pubmed ID: 12218130 Antigen-antibody Immune Complexes Empower Dendritic Cells to Efficiently Prime Specific CD8+ CTL Responses in Vivo Journal of Immunology (Baltimore, Md. : 1950). Mar, 2002 | Pubmed ID: 11859111 Reorganization of Multivesicular Bodies Regulates MHC Class II Antigen Presentation by Dendritic Cells The Journal of Cell Biology. Oct, 2001 | Pubmed ID: 11581285 Expression of the Serpin Serine Protease Inhibitor 6 Protects Dendritic Cells from Cytotoxic T Lymphocyte-induced Apoptosis: Differential Modulation by T Helper Type 1 and Type 2 Cells The Journal of Experimental Medicine. Sep, 2001 | Pubmed ID: 11535633 Efficient Identification of Novel HLA-A(*)0201-presented Cytotoxic T Lymphocyte Epitopes in the Widely Expressed Tumor Antigen PRAME by Proteasome-mediated Digestion Analysis The Journal of Experimental Medicine. Jan, 2001 | Pubmed ID: 11136822 Differential Influence on Cytotoxic T Lymphocyte Epitope Presentation by Controlled Expression of Either Proteasome Immunosubunits or PA28 The Journal of Experimental Medicine. Aug, 2000 | Pubmed ID: 10952718 Immature Dendritic Cells Acquire CD8(+) Cytotoxic T Lymphocyte Priming Capacity Upon Activation by T Helper Cell-independent or -dependent Stimuli The Journal of Experimental Medicine. Jul, 2000 | Pubmed ID: 10880536 CD4 T Cells and Their Role in Antitumor Immune Responses The Journal of Experimental Medicine. Mar, 1999 | Pubmed ID: 10049938 Specific T Helper Cell Requirement for Optimal Induction of Cytotoxic T Lymphocytes Against Major Histocompatibility Complex Class II Negative Tumors The Journal of Experimental Medicine. Mar, 1998 | Pubmed ID: 9480979 Visualization and Quantification of High-Dimensional Cytometry Data using Cytofast and the Upstream Clustering Methods FlowSOM and Cytosplore Guillaume Beyrend1, Koen Stam2, Ferry Ossendorp1, Ramon Arens1 1Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2Department of Parasitology, Leiden University Medical Center JoVE 60525 Immunology and Infection
Visualization and Quantification of High-Dimensional Cytometry Data using Cytofast and the Upstream Clustering Methods FlowSOM and Cytosplore Guillaume Beyrend1, Koen Stam2, Ferry Ossendorp1, Ramon Arens1 1Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2Department of Parasitology, Leiden University Medical Center JoVE 60525 Immunology and Infection
