Hiroyuki Hioki Department of Neuroanatomy, Graduate School of Medicine Juntendo University Biography Publications Institution JoVE Articles Hiroyuki Hioki Hiroyuki Hioki is a Professor in the Department of Neuroanatomy at Juntendo University Graduate School of Medicine. He received M.D. from Faculty of Medicine Kyoto University (2003), and Ph.D. in neuroscience from Graduate School of Medicine Kyoto University (2008). He has an interest in the neuronal circuitry in the central nervous system, especially in the neocortical microcircuit. Based on what principle, does the cerebral neocortex realize higher-order functions such as cognition, thinking, memory, and emotion? To unlock the mechanisms of the functions, it is absolutely essential to understand the neural network, which forms the structural basis of the brain. This is because “without structure there is no function”. He aims to unravel the grand design of the central nervous system, especially the neocortex, while developing innovative tools to facilitate morphological analysis. Publications Uts2b is a Microbiota-regulated Gene Expressed in Vagal Afferent Neurons Connected to Enteroendocrine Cells Producing Cholecystokinin Biochemical and Biophysical Research Communications. Jun, 2022 | Pubmed ID: 35390674 Multi-scale Light Microscopy/electron Microscopy Neuronal Imaging from Brain to Synapse with a Tissue Clearing Method, ScaeSF IScience. Jan, 2022 | Pubmed ID: 35106459 Local Connections of Pyramidal Neurons to Parvalbumin-Producing Interneurons in Motor-Associated Cortical Areas of Mice ENeuro. Jan-Feb, 2022 | Pubmed ID: 34965927 Kv4.2-Positive Domains on Dendrites in the Mouse Medial Geniculate Body Receive Ascending Excitatory and Inhibitory Inputs Preferentially From the Inferior Colliculus Frontiers in Neuroscience. Month, 2021 | Pubmed ID: 34658777 Susceptibility of Subregions of Prefrontal Cortex and Corpus Callosum to Damage by High-dose Oxytocin-induced Labor in Male Neonatal Mice PloS One. Month, 2021 | Pubmed ID: 34437622 Application of a Tissue Clearing Method for the Analysis of Dopaminergic Axonal Projections Methods in Molecular Biology (Clifton, N.J.). Month, 2021 | Pubmed ID: 34043200 High-fat Diet-induced Activation of SGK1 Promotes Alzheimer's Disease-associated Tau Pathology Human Molecular Genetics. 08, 2021 | Pubmed ID: 33890983 Fast, Cell-resolution, Contiguous-wide Two-photon Imaging to Reveal Functional Network Architectures Across Multi-modal Cortical Areas Neuron. 06, 2021 | Pubmed ID: 33878295 Structural Basis for Noradrenergic Regulation of Neural Circuits in the Mouse Olfactory Bulb The Journal of Comparative Neurology. 06, 2021 | Pubmed ID: 33616936 Tb-doped Fluorescent Glass for Biology Science Advances. 01, 2021 | Pubmed ID: 33523970 Exclusive Labeling of Direct and Indirect Pathway Neurons in the Mouse Neostriatum by an Adeno-associated Virus Vector with Cre/lox System STAR Protocols. 03, 2021 | Pubmed ID: 33364620 A Hypothalamic Novelty Signal Modulates Hippocampal Memory Nature. 10, 2020 | Pubmed ID: 32999460 Overlapping Projections of Neighboring Direct and Indirect Pathway Neostriatal Neurons to Globus Pallidus External Segment IScience. Aug, 2020 | Pubmed ID: 32877648 Generation of a MOR-CreER Knock-in Mouse Line to Study Cells and Neural Circuits Involved in Mu Opioid Receptor Signaling Genesis (New York, N.Y. : 2000). Oct, 2019 | Pubmed ID: 31651080 Intrinsic Projections of Layer Vb Neurons to Layers Va, III, and II in the Lateral and Medial Entorhinal Cortex of the Rat Cell Reports. 07, 2018 | Pubmed ID: 29972772 GABAergic Malfunction in the Anterior Cingulate Cortex Underlying Maternal Immune Activation-induced Social Deficits Journal of Neuroimmunology. 08, 2018 | Pubmed ID: 29957393 Preferential Inputs from Cholecystokinin-positive Neurons to the Somatic Compartment of Parvalbumin-expressing Neurons in the Mouse Primary Somatosensory Cortex Brain Research. 09, 2018 | Pubmed ID: 29792869 Hippocampal Ripples Down-regulate Synapses Science (New York, N.Y.). Feb, 2018 | Pubmed ID: 29439023 A Tissue Clearing Method for Neuronal Imaging from Mesoscopic to Microscopic Scales Kenta Yamauchi1,2, Shinichiro Okamoto1,2,3, Megumu Takahashi1,2,4,5, Masato Koike2,3, Takahiro Furuta6, Hiroyuki Hioki1,2,7 1Department of Neuroanatomy, Juntendo University Graduate School of Medicine, 2Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, 3Advanced Research Institute for Health Sciences, Juntendo University, 4Department of Neuroscience, Graduate School of Medicine, Kyoto University, 5Japan Society for the Promotion of Science, 6Department of Oral Anatomy and Neurobiology, Graduate School of Dentistry, Osaka University, 7Department of Multi-Scale Brain Structure Imaging, Juntendo University Graduate School of Medicine JoVE 63941 Neuroscience
A Tissue Clearing Method for Neuronal Imaging from Mesoscopic to Microscopic Scales Kenta Yamauchi1,2, Shinichiro Okamoto1,2,3, Megumu Takahashi1,2,4,5, Masato Koike2,3, Takahiro Furuta6, Hiroyuki Hioki1,2,7 1Department of Neuroanatomy, Juntendo University Graduate School of Medicine, 2Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, 3Advanced Research Institute for Health Sciences, Juntendo University, 4Department of Neuroscience, Graduate School of Medicine, Kyoto University, 5Japan Society for the Promotion of Science, 6Department of Oral Anatomy and Neurobiology, Graduate School of Dentistry, Osaka University, 7Department of Multi-Scale Brain Structure Imaging, Juntendo University Graduate School of Medicine JoVE 63941 Neuroscience
