Irwin Davidson

Publications

• MITF-high and MITF-low Cells and a Novel Subpopulation Expressing Genes of Both Cell States Contribute to Intra and Inter-tumoral Heterogeneity of Primary Melanoma
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2017  |   Pubmed ID: 28855355
• Selective Elimination of Long INterspersed Element-1 Expressing Tumour Cells by Targeted Expression of the HSV-TK Suicide Gene
  Oncotarget. Jun, 2017  |   Pubmed ID: 28415677
• Hypomorphic Pathogenic Variants in TAF13 Are Associated with Autosomal-Recessive Intellectual Disability and Microcephaly
  American Journal of Human Genetics. Mar, 2017  |   Pubmed ID: 28257693
• TEAD Transcription Factors Are Required for Normal Primary Myoblast Differentiation in Vitro and Muscle Regeneration in Vivo
  PLoS Genetics. Feb, 2017  |   Pubmed ID: 28178271
• Macrophage Production and Activation Are Dependent on TRIM33
  Oncotarget. Jan, 2017  |   Pubmed ID: 27974684
• TRF2 is Recruited to the Pre-initiation Complex As a Testis-specific Subunit of TFIIA/ALF to Promote Haploid Cell Gene Expression
  Scientific Reports. Aug, 2016  |   Pubmed ID: 27576952
• Essential Role of the TFIID Subunit TAF4 in Murine Embryogenesis and Embryonic Stem Cell Differentiation
  Nature Communications. Mar, 2016  |   Pubmed ID: 27026076
• Melanoma Addiction to the Long Non-coding RNA SAMMSON
  Nature. Mar, 2016  |   Pubmed ID: 27008969
• T-cell-intrinsic Tif1α/Trim24 Regulates IL-1R Expression on TH2 Cells and TH2 Cell-mediated Airway Allergy
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2016  |   Pubmed ID: 26787865
• TRIM33 Switches off Ifnb1 Gene Transcription During the Late Phase of Macrophage Activation
  Nature Communications. Nov, 2015  |   Pubmed ID: 26592194
• MITF and C-Jun Antagonism Interconnects Melanoma Dedifferentiation with Pro-inflammatory Cytokine Responsiveness and Myeloid Cell Recruitment
  Nature Communications. Nov, 2015  |   Pubmed ID: 26530832
• Chromatin-Remodelling Complex NURF Is Essential for Differentiation of Adult Melanocyte Stem Cells
  PLoS Genetics. Oct, 2015  |   Pubmed ID: 26440048
• Retinoic Acid Receptors Control Spermatogonia Cell-Fate and Induce Expression of the SALL4A Transcription Factor
  PLoS Genetics. Oct, 2015  |   Pubmed ID: 26427057
• MITF is a Critical Regulator of the Carcinoembryonic Antigen-related Cell Adhesion Molecule 1 (CEACAM1) in Malignant Melanoma
  Pigment Cell & Melanoma Research. Nov, 2015  |   Pubmed ID: 26301891
• A Brn2-Zic1 Axis Specifies the Neuronal Fate of Retinoic-acid-treated Embryonic Stem Cells
  Journal of Cell Science. Jul, 2015  |   Pubmed ID: 25991548
• Transcription Factor MITF and Remodeller BRG1 Define Chromatin Organisation at Regulatory Elements in Melanoma Cells
  ELife. Mar, 2015  |   Pubmed ID: 25803486
• Neuronal Identity Genes Regulated by Super-enhancers Are Preferentially Down-regulated in the Striatum of Huntington's Disease Mice
  Human Molecular Genetics. Jun, 2015  |   Pubmed ID: 25784504
• No Evidence for Generation of Alternatively Spliced Isoforms from the Mutated Trim24 Allele Lacking Exon 4 in Mouse Liver
  Journal of Hepatology. Jul, 2015  |   Pubmed ID: 25701693
• Structural Basis of Natural Promoter Recognition by the Retinoid X Nuclear Receptor
  Scientific Reports. Feb, 2015  |   Pubmed ID: 25645674
• TAF4, a Subunit of Transcription Factor II D, Directs Promoter Occupancy of Nuclear Receptor HNF4A During Post-natal Hepatocyte Differentiation
  ELife. Sep, 2014  |   Pubmed ID: 25209997
• TAF4 Inactivation Reveals the 3 Dimensional Growth Promoting Activities of Collagen 6A3
  PloS One. 2014  |   Pubmed ID: 24498316
• Sumoylation at Chromatin Governs Coordinated Repression of a Transcriptional Program Essential for Cell Growth and Proliferation
  Genome Research. Oct, 2013  |   Pubmed ID: 23893515
• MITF, the Janus Transcription Factor of Melanoma
  Future Oncology (London, England). Feb, 2013  |   Pubmed ID: 23414473
• Trim24-repressed VL30 Retrotransposons Regulate Gene Expression by Producing Noncoding RNA
  Nature Structural & Molecular Biology. Mar, 2013  |   Pubmed ID: 23377542
• Retinoic Acid Induces Sertoli Cell Paracrine Signals for Spermatogonia Differentiation but Cell Autonomously Drives Spermatocyte Meiosis
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012  |   Pubmed ID: 23012458
• Retinoic Acid Receptors Recognize the Mouse Genome Through Binding Elements with Diverse Spacing and Topology
  The Journal of Biological Chemistry. Jul, 2012  |   Pubmed ID: 22661711
• Interconversion Between Active and Inactive TATA-binding Protein Transcription Complexes in the Mouse Genome
  Nucleic Acids Research. Feb, 2012  |   Pubmed ID: 22013162
• The TIF1α-related TRIM Cofactors Couple Chromatin Modifications to Transcriptional Regulation, Signaling and Tumor Suppression
  Transcription. Sep-Oct, 2011  |   Pubmed ID: 22231120
• Front Seat and Back Seat Drivers of Melanoma Metastasis
  Pigment Cell & Melanoma Research. Oct, 2011  |   Pubmed ID: 21910852
• Transcription Cofactors TRIM24, TRIM28, and TRIM33 Associate to Form Regulatory Complexes That Suppress Murine Hepatocellular Carcinoma
  Proceedings of the National Academy of Sciences of the United States of America. May, 2011  |   Pubmed ID: 21531907
• SeqMINER: an Integrated ChIP-seq Data Interpretation Platform
  Nucleic Acids Research. Mar, 2011  |   Pubmed ID: 21177645
• Cell-specific Occupancy of an Extended Repertoire of CREM and CREB Binding Loci in Male Germ Cells
  BMC Genomics. Sep, 2010  |   Pubmed ID: 20920259
• Genome-wide Analysis of POU3F2/BRN2 Promoter Occupancy in Human Melanoma Cells Reveals Kitl As a Novel Regulated Target Gene
  Pigment Cell & Melanoma Research. Jun, 2010  |   Pubmed ID: 20337985
• Cell-specific Interaction of Retinoic Acid Receptors with Target Genes in Mouse Embryonic Fibroblasts and Embryonic Stem Cells
  Molecular and Cellular Biology. Jan, 2010  |   Pubmed ID: 19884340
• Recent Advances in Understanding the Structure and Function of General Transcription Factor TFIID
  Cellular and Molecular Life Sciences : CMLS. Jul, 2009  |   Pubmed ID: 19308322
• Specialization of the General Transcriptional Machinery in Male Germ Cells
  Cell Cycle (Georgetown, Tex.). Nov, 2008  |   Pubmed ID: 19001848
• TIPT, a Male Germ Cell-specific Partner of TRF2, is Chromatin-associated and Interacts with HP1
  Cell Cycle (Georgetown, Tex.). May, 2008  |   Pubmed ID: 18418073
• The TFIID Subunit TAF4 Regulates Keratinocyte Proliferation and Has Cell-autonomous and Non-cell-autonomous Tumour Suppressor Activity in Mouse Epidermis
  Development (Cambridge, England). Aug, 2007  |   Pubmed ID: 17626060
• New Insights into TAFs As Regulators of Cell Cycle and Signaling Pathways
  Cell Cycle (Georgetown, Tex.). Nov, 2005  |   Pubmed ID: 16205117
• TAF4 Inactivation in Embryonic Fibroblasts Activates TGF Beta Signalling and Autocrine Growth
  The EMBO Journal. Aug, 2005  |   Pubmed ID: 16015375
• Proteolytic Cleavage of ALF into Alpha- and Beta-subunits That Form Homologous and Heterologous Complexes with Somatic TFIIA and TRF2 in Male Germ Cells
  FEBS Letters. Jun, 2005  |   Pubmed ID: 15927180
• Polar Nuclear Localization of H1T2, a Histone H1 Variant, Required for Spermatid Elongation and DNA Condensation During Spermiogenesis
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005  |   Pubmed ID: 15710904
• Preparation, Isolation and Characterization of Stage-specific Spermatogenic Cells for Cellular and Molecular Analysis
  Nature Methods. Dec, 2004  |   Pubmed ID: 16144087
• Cell-specific Nucleolar Localization of TBP-related Factor 2
  Molecular Biology of the Cell. Oct, 2004  |   Pubmed ID: 15269281
• Testis-specific Transcription Mechanisms Promoting Male Germ-cell Differentiation
  Reproduction (Cambridge, England). Jul, 2004  |   Pubmed ID: 15232059
• [TBP, a Universal Transcription Factor?]
  Medecine Sciences : M/S. May, 2004  |   Pubmed ID: 15190478
• The Genetics of TBP and TBP-related Factors
  Trends in Biochemical Sciences. Jul, 2003  |   Pubmed ID: 12878007
• The Intracellular Localisation of TAF7L, a Paralogue of Transcription Factor TFIID Subunit TAF7, is Developmentally Regulated During Male Germ-cell Differentiation
  Journal of Cell Science. May, 2003  |   Pubmed ID: 12665565
• RNA Polymerase II Transcription in Murine Cells Lacking the TATA Binding Protein
  Science (New York, N.Y.). Nov, 2002  |   Pubmed ID: 12411709
• Crystal Structure of a Subcomplex of Human Transcription Factor TFIID Formed by TATA Binding Protein-associated Factors HTAF4 (hTAF(II)135) and HTAF12 (hTAF(II)20)
  The Journal of Biological Chemistry. Nov, 2002  |   Pubmed ID: 12237304
• Functional Analysis of the TFIID-specific Yeast TAF4 (yTAF(II)48) Reveals an Unexpected Organization of Its Histone-fold Domain
  The Journal of Biological Chemistry. Nov, 2002  |   Pubmed ID: 12237303
• Distinct Mutations in Yeast TAF(II)25 Differentially Affect the Composition of TFIID and SAGA Complexes As Well As Global Gene Expression Patterns
  Molecular and Cellular Biology. May, 2002  |   Pubmed ID: 11940675
• Distinct Functions of TBP and TLF/TRF2 During Spermatogenesis: Requirement of TLF for Heterochromatic Chromocenter Formation in Haploid Round Spermatids
  Development (Cambridge, England). Feb, 2002  |   Pubmed ID: 11861477
• The TFIID Components Human TAF(II)140 and Drosophila BIP2 (TAF(II)155) Are Novel Metazoan Homologues of Yeast TAF(II)47 Containing a Histone Fold and a PHD Finger
  Molecular and Cellular Biology. Aug, 2001  |   Pubmed ID: 11438666
• Histone Folds Mediate Selective Heterodimerization of Yeast TAF(II)25 with TFIID Components YTAF(II)47 and YTAF(II)65 and with SAGA Component YSPT7
  Molecular and Cellular Biology. Mar, 2001  |   Pubmed ID: 11238921
• The Human TFIID Components TAF(II)135 and TAF(II)20 and the Yeast SAGA Components ADA1 and TAF(II)68 Heterodimerize to Form Histone-like Pairs
  Molecular and Cellular Biology. Jan, 2000  |   Pubmed ID: 10594036
• Human TAF(II)55 Interacts with the Vitamin D(3) and Thyroid Hormone Receptors and with Derivatives of the Retinoid X Receptor That Have Altered Transactivation Properties
  Molecular and Cellular Biology. Aug, 1999  |   Pubmed ID: 10409738
• Synergistic Transcriptional Activation by TATA-binding Protein and HTAFII28 Requires Specific Amino Acids of the HTAFII28 Histone Fold
  Molecular and Cellular Biology. Jul, 1999  |   Pubmed ID: 10373554