Daniel Metzger

Publications

• Androgen Receptor Coordinates Muscle Metabolic and Contractile Functions
  Journal of Cachexia, Sarcopenia and Muscle. May, 2023  |   Pubmed ID: 37208984
• Hypoxia-inducible Factor 1A Inhibition Overcomes Castration Resistance of Prostate Tumors
  EMBO Molecular Medicine. Jun, 2023  |   Pubmed ID: 37070472
• Vitamin D Analogs Bearing C-20 Modifications Stabilize the Agonistic Conformation of Non-Responsive Vitamin D Receptor Variants
  International Journal of Molecular Sciences. Jul, 2022  |   Pubmed ID: 35955580
• Hypoxia-mediated Stabilization of HIF1A in Prostatic Intraepithelial Neoplasia Promotes Cell Plasticity and Malignant Progression
  Science Advances. Jul, 2022  |   Pubmed ID: 35867798
• TRPC3 Shapes the ER-mitochondria Ca Transfer Characterizing Tumour-promoting Senescence
  Nature Communications. Feb, 2022  |   Pubmed ID: 35177596
• Single-cell Analyses Unravel Cell Type-specific Responses to a Vitamin D Analog in Prostatic Precancerous Lesions
  Science Advances. Jul, 2021  |   Pubmed ID: 34330705
• Myod1 and GR Coordinate Myofiber-specific Transcriptional Enhancers
  Nucleic Acids Research. May, 2021  |   Pubmed ID: 33836079
• Tyrosine Hydroxylase Conditional KO Mice Reveal Peripheral Tissue-dependent Differences in Dopamine Biosynthetic Pathways
  The Journal of Biological Chemistry. 2021  |   Pubmed ID: 33737022
• Cytosolic Sequestration of the Vitamin D Receptor As a Therapeutic Option for Vitamin D-induced Hypercalcemia
  Nature Communications. Dec, 2020  |   Pubmed ID: 33288743
• Aging Exacerbates Ischemia-Reperfusion-Induced Mitochondrial Respiration Impairment in Skeletal Muscle
  Antioxidants (Basel, Switzerland). Jun, 2019  |   Pubmed ID: 31181751
• Skeletal Muscle-Specific Activation of G Signaling Maintains Glucose Homeostasis
  Diabetes. Jun, 2019  |   Pubmed ID: 30936140
• Senescence Controls Prostatic Neoplasia Driven by Pten Loss
  Molecular & Cellular Oncology. 2019  |   Pubmed ID: 30788414
• PGC-1β Modulates Statin-associated Myotoxicity in Mice
  Archives of Toxicology. Feb, 2019  |   Pubmed ID: 30511338
• [How to Limit the Progression of PTEN-deficient Prostatic Tumors?]
  Medecine Sciences : M/S. Nov, 2018  |   Pubmed ID: 30526823
• Short-Term Fasting Reveals Amino Acid Metabolism As a Major Sex-Discriminating Factor in the Liver
  Cell Metabolism. Aug, 2018  |   Pubmed ID: 29909969
• Diabetes Worsens Skeletal Muscle Mitochondrial Function, Oxidative Stress, and Apoptosis After Lower-Limb Ischemia-Reperfusion: Implication of the RISK and SAFE Pathways?
  Frontiers in Physiology. 2018  |   Pubmed ID: 29872405
• Deletion in Luminal Cells of Mature Prostate Induces Replication Stress and Senescence in Vivo
  The Journal of Experimental Medicine. Jun, 2018  |   Pubmed ID: 29743291
• The Histone Code Reader Spin1 Controls Skeletal Muscle Development
  Cell Death & Disease. Nov, 2017  |   Pubmed ID: 29168801
• Peroxisome Proliferator-activated Receptor Gamma (PPARγ) Regulates Lactase Expression and Activity in the Gut
  EMBO Molecular Medicine. Sep, 2017  |   Pubmed ID: 28947679
• Moderate Exercise Allows for Shorter Recovery Time in Critical Limb Ischemia
  Frontiers in Physiology. 2017  |   Pubmed ID: 28790926
• BRG1-SWI/SNF-dependent Regulation of the Wt1 Transcriptional Landscape Mediates Epicardial Activity During Heart Development and Disease
  Nature Communications. Jul, 2017  |   Pubmed ID: 28737171
• IFN-β-induced Reactive Oxygen Species and Mitochondrial Damage Contribute to Muscle Impairment and Inflammation Maintenance in Dermatomyositis
  Acta Neuropathologica. Jun, 2017  |   Pubmed ID: 28623559
• Androgen Signaling Negatively Controls Group 2 Innate Lymphoid Cells
  The Journal of Experimental Medicine. Jun, 2017  |   Pubmed ID: 28484078
• The Nuclear Receptor Nr4a1 Acts As a Microglia Rheostat and Serves As a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation
  Journal of Immunology (Baltimore, Md. : 1950). May, 2017  |   Pubmed ID: 28411187
• Gonad-related Factors Promote Muscle Performance Gain During Postnatal Development in Male and Female Mice
  American Journal of Physiology. Endocrinology and Metabolism. Jul, 2017  |   Pubmed ID: 28351832
• Nur77 Deletion Impairs Muscle Growth During Developmental Myogenesis and Muscle Regeneration in Mice
  PloS One. 2017  |   Pubmed ID: 28170423
• Regeneration of Fat Cells from Myofibroblasts During Wound Healing
  Science (New York, N.Y.). 02, 2017  |   Pubmed ID: 28059714
• Muscle Expression of a Malonyl-CoA-insensitive Carnitine Palmitoyltransferase-1 Protects Mice Against High-fat/high-sucrose Diet-induced Insulin Resistance
  American Journal of Physiology. Endocrinology and Metabolism. Sep, 2016  |   Pubmed ID: 27507552
• SOX4 Is Essential for Prostate Tumorigenesis Initiated by PTEN Ablation
  Cancer Research. Mar, 2016  |   Pubmed ID: 26701805
• The Transcriptional Coregulator PGC-1β Controls Mitochondrial Function and Anti-oxidant Defence in Skeletal Muscles
  Nature Communications. Dec, 2015  |   Pubmed ID: 26674215
• Patrolling Monocytes Control Tumor Metastasis to the Lung
  Science (New York, N.Y.). Nov, 2015  |   Pubmed ID: 26494174
• VDR and Gemini Ligands
  Oncotarget. Oct, 2015  |   Pubmed ID: 26356569
• A Vitamin D Receptor Selectively Activated by Gemini Analogs Reveals Ligand Dependent and Independent Effects
  Cell Reports. Feb, 2015  |   Pubmed ID: 25620699
• The Orphan Nuclear Receptor Nur77 is a Determinant of Myofiber Size and Muscle Mass in Mice
  Molecular and Cellular Biology. Apr, 2015  |   Pubmed ID: 25605333
• Orphan Nuclear Receptor NR4A1 Regulates Transforming Growth Factor-β Signaling and Fibrosis
  Nature Medicine. Feb, 2015  |   Pubmed ID: 25581517
• Retinoid X Receptors Orchestrate Osteoclast Differentiation and Postnatal Bone Remodeling
  The Journal of Clinical Investigation. Feb, 2015  |   Pubmed ID: 25574839
• Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type
  Developmental Cell. Dec, 2014  |   Pubmed ID: 25465495
• Clearance of PML/RARA-bound Promoters Suffice to Initiate APL Differentiation
  Blood. Dec, 2014  |   Pubmed ID: 25258343
• Myofiber Androgen Receptor Promotes Maximal Mechanical Overload-induced Muscle Hypertrophy and Fiber Type Transition in Male Mice
  Endocrinology. Dec, 2014  |   Pubmed ID: 25216388
• Mammary Stem Cells Have Myoepithelial Cell Properties
  Nature Cell Biology. Oct, 2014  |   Pubmed ID: 25173976
• Brg1 Loss Attenuates Aberrant Wnt-signalling and Prevents Wnt-dependent Tumourigenesis in the Murine Small Intestine
  PLoS Genetics. Jul, 2014  |   Pubmed ID: 25010414
• LSD1 Promotes Oxidative Metabolism of White Adipose Tissue
  Nature Communications. Jun, 2014  |   Pubmed ID: 24912735
• Acute Effect of Androgens on Maximal Force-generating Capacity and Electrically Evoked Calcium Transient in Mouse Skeletal Muscles
  Steroids. Sep, 2014  |   Pubmed ID: 24844204
• Skeletal Myofiber VEGF is Essential for the Exercise Training Response in Adult Mice
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Apr, 2014  |   Pubmed ID: 24523345
• Lysine-specific Demethylase 1 Regulates Differentiation Onset and Migration of Trophoblast Stem Cells
  Nature Communications. 2014  |   Pubmed ID: 24448552
• Nurr1 Expression is Regulated by Voltage-dependent Calcium Channels and Calcineurin in Cultured Hippocampal Neurons
  Neuroscience Letters. Jan, 2014  |   Pubmed ID: 24291696
• Retinoid Signaling in Progenitors Controls Specification and Regeneration of the Urothelium
  Developmental Cell. Sep, 2013  |   Pubmed ID: 23993789
• Smoothened is a Master Regulator of Adult Liver Repair
  The Journal of Clinical Investigation. Jun, 2013  |   Pubmed ID: 23563311
• Genetically Engineered Mouse Models of Prostate Cancer
  Molecular Oncology. Apr, 2013  |   Pubmed ID: 23481269
• Polyphenols Prevent Ageing-related Impairment in Skeletal Muscle Mitochondrial Function Through Decreased Reactive Oxygen Species Production
  Experimental Physiology. Feb, 2013  |   Pubmed ID: 22903980
• PPARβ/δ Affects Pancreatic β Cell Mass and Insulin Secretion in Mice
  The Journal of Clinical Investigation. Nov, 2012  |   Pubmed ID: 23093780
• Cell Autonomous Lipin 1 Function is Essential for Development and Maintenance of White and Brown Adipose Tissue
  Molecular and Cellular Biology. Dec, 2012  |   Pubmed ID: 23028044
• Temporally Controlled Targeted Somatic Mutagenesis in Mouse Eye Pigment Epithelium
  Genesis (New York, N.Y. : 2000). Nov, 2012  |   Pubmed ID: 22730183
• Generation of Spatio-Temporally Controlled Targeted Somatic Mutations in the Mouse
  Current Protocols in Mouse Biology. Mar, 2011  |   Pubmed ID: 26068987
• Compensatory Regulation of Dopamine After Ablation of the Tyrosine Hydroxylase Gene in the Nigrostriatal Projection
  The Journal of Biological Chemistry. Dec, 2011  |   Pubmed ID: 22027820
• Regenerated Luminal Epithelial Cells Are Derived from Preexisting Luminal Epithelial Cells in Adult Mouse Prostate
  Molecular Endocrinology (Baltimore, Md.). Nov, 2011  |   Pubmed ID: 21940754
• Hypoxia-inducible Transcription Factor 2α Promotes Steatohepatitis Through Augmenting Lipid Accumulation, Inflammation, and Fibrosis
  Hepatology (Baltimore, Md.). Aug, 2011  |   Pubmed ID: 21538443
• Widespread Negative Response Elements Mediate Direct Repression by Agonist-liganded Glucocorticoid Receptor
  Cell. Apr, 2011  |   Pubmed ID: 21496643
• Chromatin Remodelling Complex Dosage Modulates Transcription Factor Function in Heart Development
  Nature Communications. 2011  |   Pubmed ID: 21304516
• Chromatin Remodeling Enzyme Brg1 is Required for Mouse Lens Fiber Cell Terminal Differentiation and Its Denucleation
  Epigenetics & Chromatin. Nov, 2010  |   Pubmed ID: 21118511
• The Transcriptional Coregulators TIF2 and SRC-1 Regulate Energy Homeostasis by Modulating Mitochondrial Respiration in Skeletal Muscles
  Cell Metabolism. Nov, 2010  |   Pubmed ID: 21035760
• Myocytic Androgen Receptor Controls the Strength but Not the Mass of Limb Muscles
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2010  |   Pubmed ID: 20660752
• Thymic Stromal Lymphopoietin Overproduced by Keratinocytes in Mouse Skin Aggravates Experimental Asthma
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2009  |   Pubmed ID: 19188585
• Dual Role of COUP-TF-interacting Protein 2 in Epidermal Homeostasis and Permeability Barrier Formation
  The Journal of Investigative Dermatology. Jun, 2009  |   Pubmed ID: 19092943
• LRP1 Controls Intracellular Cholesterol Storage and Fatty Acid Synthesis Through Modulation of Wnt Signaling
  The Journal of Biological Chemistry. Jan, 2009  |   Pubmed ID: 18990694
• Expanded CTG Repeats Within the DMPK 3' UTR Causes Severe Skeletal Muscle Wasting in an Inducible Mouse Model for Myotonic Dystrophy
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008  |   Pubmed ID: 18272483
• Temporally Controlled Ablation of PTEN in Adult Mouse Prostate Epithelium Generates a Model of Invasive Prostatic Adenocarcinoma
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008  |   Pubmed ID: 18268330
• Loss of Trim24 (Tif1alpha) Gene Function Confers Oncogenic Activity to Retinoic Acid Receptor Alpha
  Nature Genetics. Dec, 2007  |   Pubmed ID: 18026104
• Compromised Intestinal Lipid Absorption in Mice with a Liver-specific Deficiency of Liver Receptor Homolog 1
  Molecular and Cellular Biology. Dec, 2007  |   Pubmed ID: 17908794
• LRH-1-mediated Glucocorticoid Synthesis in Enterocytes Protects Against Inflammatory Bowel Disease
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2007  |   Pubmed ID: 17670946
• The TFIID Subunit TAF4 Regulates Keratinocyte Proliferation and Has Cell-autonomous and Non-cell-autonomous Tumour Suppressor Activity in Mouse Epidermis
  Development (Cambridge, England). Aug, 2007  |   Pubmed ID: 17626060
• Adipose Tissue-specific Inactivation of the Retinoblastoma Protein Protects Against Diabesity Because of Increased Energy Expenditure
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2007  |   Pubmed ID: 17556545
• Malignant Transformation of DMBA/TPA-induced Papillomas and Nevi in the Skin of Mice Selectively Lacking Retinoid-X-receptor Alpha in Epidermal Keratinocytes
  The Journal of Investigative Dermatology. May, 2007  |   Pubmed ID: 17301838
• Topical Vitamin D3 and Low-calcemic Analogs Induce Thymic Stromal Lymphopoietin in Mouse Keratinocytes and Trigger an Atopic Dermatitis
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2006  |   Pubmed ID: 16880407
• Genetic and Pharmacological Evidence That a Retinoic Acid Cannot Be the RXR-activating Ligand in Mouse Epidermis Keratinocytes
  Genes & Development. Jun, 2006  |   Pubmed ID: 16751185
• Retinoid X Receptor Ablation in Adult Mouse Keratinocytes Generates an Atopic Dermatitis Triggered by Thymic Stromal Lymphopoietin
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2005  |   Pubmed ID: 16199515
• Temporally Controlled Targeted Somatic Mutagenesis in Embryonic Surface Ectoderm and Fetal Epidermal Keratinocytes Unveils Two Distinct Developmental Functions of BRG1 in Limb Morphogenesis and Skin Barrier Formation
  Development (Cambridge, England). Oct, 2005  |   Pubmed ID: 16192310
• Temporally Controlled Targeted Somatic Mutagenesis in Skeletal Muscles of the Mouse
  Genesis (New York, N.Y. : 2000). Apr, 2005  |   Pubmed ID: 15789425
• Targeted Somatic Mutagenesis in the Mouse Epidermis
  Methods in Molecular Biology (Clifton, N.J.). 2005  |   Pubmed ID: 15502196
• Peroxisome Proliferator-activated Receptor Gamma is Required in Mature White and Brown Adipocytes for Their Survival in the Mouse
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004  |   Pubmed ID: 15070754
• Friedreich Ataxia Mouse Models with Progressive Cerebellar and Sensory Ataxia Reveal Autophagic Neurodegeneration in Dorsal Root Ganglia
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2004  |   Pubmed ID: 14985441
• Retinal Dystrophy Resulting from Ablation of RXR Alpha in the Mouse Retinal Pigment Epithelium
  The American Journal of Pathology. Feb, 2004  |   Pubmed ID: 14742273
• Targeted Conditional Somatic Mutagenesis in the Mouse: Temporally-controlled Knock out of Retinoid Receptors in Epidermal Keratinocytes
  Methods in Enzymology. 2003  |   Pubmed ID: 14631857
• TAF10 (TAF(II)30) is Necessary for TFIID Stability and Early Embryogenesis in Mice
  Molecular and Cellular Biology. Jun, 2003  |   Pubmed ID: 12773572
• Temporally Controlled Site-specific Mutagenesis in the Germ Cell Lineage of the Mouse Testis
  Biology of Reproduction. Feb, 2003  |   Pubmed ID: 12533419
• Physiological and Retinoid-induced Proliferations of Epidermis Basal Keratinocytes Are Differently Controlled
  The EMBO Journal. Jul, 2002  |   Pubmed ID: 12093741
• Germ Cell Expression of the Transcriptional Co-repressor TIF1beta is Required for the Maintenance of Spermatogenesis in the Mouse
  Development (Cambridge, England). May, 2002  |   Pubmed ID: 11973266
• Selective Ablation of Retinoid X Receptor Alpha in Hepatocytes Impairs Their Lifespan and Regenerative Capacity
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2001  |   Pubmed ID: 11287642
• Impaired Adipogenesis and Lipolysis in the Mouse Upon Selective Ablation of the Retinoid X Receptor Alpha Mediated by a Tamoxifen-inducible Chimeric Cre Recombinase (Cre-ERT2) in Adipocytes
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2001  |   Pubmed ID: 11134524
• Purification and Identification of P68 RNA Helicase Acting As a Transcriptional Coactivator Specific for the Activation Function 1 of Human Estrogen Receptor Alpha
  Molecular and Cellular Biology. Aug, 1999  |   Pubmed ID: 10409727
• Spatio-temporally Controlled Site-specific Somatic Mutagenesis in the Mouse
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 1997  |   Pubmed ID: 9405652
• Specific and Redundant Functions of Retinoid X Receptor/Retinoic Acid Receptor Heterodimers in Differentiation, Proliferation, and Apoptosis of F9 Embryonal Carcinoma Cells
  The Journal of Cell Biology. Nov, 1997  |   Pubmed ID: 9348290