Jacco van Rheenen Department of Molecular Pathology The Netherlands Cancer Institute Biography Publications Institution JoVE Articles Jacco van Rheenen has not added a biography. If you are Jacco van Rheenen and would like to personalize this page please email our Author Liaison for assistance. Publications A Living Biobank of Patient-derived Ductal Carcinoma in Situ Mouse-intraductal Xenografts Identifies Risk Factors for Invasive Progression Cancer Cell. May, 2023 | Pubmed ID: 37116492 A Lamb1Dendra2 Mouse Model Identifies Basement-membrane-producing Origins and Dynamics in PyMT Breast Tumors Developmental Cell. Apr, 2023 | Pubmed ID: 36905927 Subtype-specific Kinase Dependency Regulates Growth and Metastasis of Poor-prognosis Mesenchymal Colorectal Cancer Journal of Experimental & Clinical Cancer Research : CR. Mar, 2023 | Pubmed ID: 36869386 Author Correction: Epithelial TGFβ Engages Growth-factor Signalling to Circumvent Apoptosis and Drive Intestinal Tumourigenesis with Aggressive Features Nature Communications. Jan, 2023 | Pubmed ID: 36720858 Coordinated Cancer Chaos Cell. Jan, 2023 | Pubmed ID: 36669470 Multidimensional Imaging of Breast Cancer Cold Spring Harbor Perspectives in Medicine. May, 2023 | Pubmed ID: 36167726 Epithelial TGFβ Engages Growth-factor Signalling to Circumvent Apoptosis and Drive Intestinal Tumourigenesis with Aggressive Features Nature Communications. Dec, 2022 | Pubmed ID: 36477656 Re-purposing the Pro-senescence Properties of Doxorubicin to Introduce Immunotherapy in Breast Cancer Brain Metastasis Cell Reports. Medicine. Nov, 2022 | Pubmed ID: 36384097 A Doxycycline- and Light-inducible Cre Recombinase Mouse Model for Optogenetic Genome Editing Nature Communications. Oct, 2022 | Pubmed ID: 36307419 Author Correction: PHGDH Heterogeneity Potentiates Cancer Cell Dissemination and Metastasis Nature. Sep, 2022 | Pubmed ID: 36042336 Retrograde Movements Determine Effective Stem Cell Numbers in the Intestine Nature. Jul, 2022 | Pubmed ID: 35831497 Epithelial-to-Mesenchymal Transition Drives Invasiveness of Breast Cancer Brain Metastases Cancers. Jun, 2022 | Pubmed ID: 35804890 PHGDH Heterogeneity Potentiates Cancer cell Dissemination and Metastasis Nature. May, 2022 | Pubmed ID: 35585241 GFAP Splice Variants Fine-tune Glioma Cell Invasion and Tumour Dynamics by Modulating Migration Persistence Scientific Reports. Jan, 2022 | Pubmed ID: 35013418 Differential Survival and Therapy Benefit of Breast Cancer Patients Are Characterized by Distinct Epithelial and Immune Cell Microenvironments Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2021 | Pubmed ID: 34965952 Regulation of a Progenitor Gene Program by SOX4 is Essential for Mammary Tumor Proliferation Oncogene. Nov, 2021 | Pubmed ID: 34584219 RASSF1C Oncogene Elicits Amoeboid Invasion, Cancer Stemness, and Extracellular Vesicle Release Via a SRC/Rho Axis The EMBO Journal. Oct, 2021 | Pubmed ID: 34532864 Single-cell Analysis of Regions of Interest (SCARI) Using a Photosensitive Tag Nature Chemical Biology. Nov, 2021 | Pubmed ID: 34504322 Diverse Transcriptional Regulation and Functional Effects Revealed by CRISPR/Cas9-directed Epigenetic Editing Oncotarget. Aug, 2021 | Pubmed ID: 34434494 Epithelial-to-Mesenchymal Transition in the Light of Plasticity and Hybrid E/M States Journal of Clinical Medicine. May, 2021 | Pubmed ID: 34072345 LGR6 Marks Nephron Progenitor Cells Developmental Dynamics : an Official Publication of the American Association of Anatomists. Apr, 2021 | Pubmed ID: 33848015 Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part Via Hypoxia-Induced Quiescence Cells. Mar, 2021 | Pubmed ID: 33801903 A Comprehensive Enhancer Screen Identifies TRAM2 As a Key and Novel Mediator of YAP Oncogenesis Genome Biology. Jan, 2021 | Pubmed ID: 33514403 Scratch-induced Partial Skin Wounds Re-epithelialize by Sheets of Independently Migrating Keratinocytes Life Science Alliance. 01, 2021 | Pubmed ID: 33257474 Targeting Dormant Tumor Cells to Prevent Cancer Recurrence The FEBS Journal. Nov, 2021 | Pubmed ID: 33190412 Publisher Correction: Long-distance Modulation of Bystander Tumor Cells by CD8 T-cell-secreted IFN-γ Nature Cancer. Jul, 2020 | Pubmed ID: 35122043 An Unanticipated Tumor-suppressive Role of the SUMO Pathway in the Intestine Unveiled by Ubc9 Haploinsufficiency Oncogene. Oct, 2020 | Pubmed ID: 32948837 Calorie Restriction Increases the Number of Competing Stem Cells and Decreases Mutation Retention in the Intestine Cell Reports. 07, 2020 | Pubmed ID: 32698002 Stem Cell Lineage Survival As a Noisy Competition for Niche Access Proceedings of the National Academy of Sciences of the United States of America. 07, 2020 | Pubmed ID: 32611816 Long-distance Modulation of Bystander Tumor Cells by CD8 T Cell-secreted IFNγ Nature Cancer. Mar, 2020 | Pubmed ID: 32566933 Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer Cell Stem Cell. 04, 2020 | Pubmed ID: 32169167 Poor Perfusion of the Microvasculature in Peritoneal Metastases of Ovarian Cancer Clinical & Experimental Metastasis. Apr, 2020 | Pubmed ID: 32008138 Capturing Stem Cell Behavior Using Intravital and Live Cell Microscopy Cold Spring Harbor Perspectives in Biology. Sep, 2020 | Pubmed ID: 31767651 Cellular Plasticity During Metastasis: New Insights Provided by Intravital Microscopy Cold Spring Harbor Perspectives in Medicine. Nov, 2020 | Pubmed ID: 31615867 Fsp1-Mediated Lineage Tracing Fails to Detect the Majority of Disseminating Cells Undergoing EMT Cell Reports. 11, 2019 | Pubmed ID: 31775027 Rebalancing of Actomyosin Contractility Enables Mammary Tumor Formation Upon Loss of E-cadherin Nature Communications. Aug, 2019 | Pubmed ID: 31444332 Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids Cell Stem Cell. Jun, 2019 | Pubmed ID: 31130514 Cancer Cells Copy Migratory Behavior and Exchange Signaling Networks Via Extracellular Vesicles The EMBO Journal. 08, 2018 | Pubmed ID: 29907695 Glycosylated Extracellular Vesicles Released by Glioblastoma Cells Are Decorated by CCL18 Allowing for Cellular Uptake Via Chemokine Receptor CCR8 Journal of Extracellular Vesicles. 2018 | Pubmed ID: 29696074 A Surgical Orthotopic Organoid Transplantation Approach in Mice to Visualize and Study Colorectal Cancer Progression Nature Protocols. 02, 2018 | Pubmed ID: 29300390 Intravital Characterization of Tumor Cell Migration in Pancreatic Cancer Intravital. 2016 | Pubmed ID: 28243522 A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility Cell. Apr, 2016 | Pubmed ID: 27058664 Intravital FRET Imaging of Tumor Cell Viability and Mitosis During Chemotherapy PloS One. 2013 | Pubmed ID: 23691140 Tissue-resident Memory CD8+ T Cells Continuously Patrol Skin Epithelia to Quickly Recognize Local Antigen Proceedings of the National Academy of Sciences of the United States of America. Nov, 2012 | Pubmed ID: 23150545 La Muerte Del Receptor CD95 Activa La Vía Cofilin Para El Estímulo De La Invasión Tumoral De La Célula EMBO Reports. Sep, 2011 | Pubmed ID: 21760611 Microscopía Intravital: Nuevas Perspectivas Sobre La Metástasis De Tumores Journal of Cell Science. Feb, 2011 | Pubmed ID: 21242309 Resultados De La Homeostasis Intestinal Cripta De La Competencia Neutral Entre Simétricamente División Lgr5 Células Madre Cell. Oct, 2010 | Pubmed ID: 20887898 Nano-imagen De La Membrana De La Topografía Afecta Las Interpretaciones En Biología Celular Nature Methods. Jul, 2010 | Pubmed ID: 20588265 Desequilibrio De La Interacción Fosfatidilinositol-4 ,5-bifosfato-cofilina Deteriora Directivo De La Célula Molecular Biology of the Cell. Nov, 2009 | Pubmed ID: 19741095 Cortactin Regula Cofilin Y Actividades N-WASP Para El Control De Las Etapas De La Asamblea Invadopodium Y Maduración The Journal of Cell Biology. Aug, 2009 | Pubmed ID: 19704022 A Base De Colágeno Modelos Migración Celular in Vitro E in Vivo Seminars in Cell & Developmental Biology. Oct, 2009 | Pubmed ID: 19682592 Un Cofilin Común Ciclo De Actividades En Las Células Tumorales Invasoras Y Las Células Inflamatorias Journal of Cell Science. Feb, 2009 | Pubmed ID: 19158339 Imagen Intravital Del Comportamiento Metastásico Través De Una Ventana De Imagen Mamaria Nature Methods. Dec, 2008 | Pubmed ID: 18997781 Investigación Sobre El Mecanismo De Localización De Planificación De Necesidades De Regulación Experimental Cell Research. Jan, 2008 | Pubmed ID: 17897642 EGF Inducida Por PIP2 Comunicados De Hidrólisis Y Activa Cofilin Localmente En Células De Carcinoma The Journal of Cell Biology. Dec, 2007 | Pubmed ID: 18086920 Fosforilación De La Serina De La Integrina Beta4 Subunidad Es Necesaria Para El Receptor De Factor De Crecimiento Epidérmico Interrupción Inducida Hemidesmosoma Molecular Biology of the Cell. Sep, 2007 | Pubmed ID: 17615294 Motilidad Celular Y El Reglamento Del Citoesqueleto De Invasión Y Metástasis Journal of Mammary Gland Biology and Neoplasia. Sep, 2007 | Pubmed ID: 17557195 Imagen Intravital De Marcadores Fluorescentes Y Sondas FRET Por El Tatuaje De ADN BMC Biotechnology. 2007 | Pubmed ID: 17201912 El Papel De La PtdIns (4,5) P2 Y PIP5Kalpha En La Regulación De La Apoptosis Inducida Por El Estrés Current Biology : CB. Sep, 2006 | Pubmed ID: 16979564 Integrina Citoplasmática De Dominio Asociado a La Proteína-1 (ICAP-1) Se Relaciona Con La Quinasa ROCK-I En La Membrana Plasmática Journal of Cellular Physiology. Sep, 2006 | Pubmed ID: 16741948 Las Integrinas Estrategia De Control Mótiles Través De Una Vía Rho-cofilina The Journal of Cell Biology. May, 2005 | Pubmed ID: 15866889 PIP2 De Señalización En Los Dominios De Lípidos: Una Evaluación Crítica Re- The EMBO Journal. May, 2005 | Pubmed ID: 15861130 La Separación Espacial De Las Interacciones HLA-DM/HLA-DR Dentro De Escape Inmune Inducida Por MIIC Y Fagosoma- Immunity. Feb, 2005 | Pubmed ID: 15723810 Corrección De Adquisición Confocal Para Optimizar La Imagen De La Transferencia De Energía De Resonancia Fluorescente Por La Emisión Sensibilizada Biophysical Journal. Apr, 2004 | Pubmed ID: 15041688 Inducida Por Agonista PIP (2) La Hidrólisis Inhibe La Dinámica De Actina Cortical: El Reglamento En Un Mundial, Pero No En Una Escala Del Micrómetro Molecular Biology of the Cell. Sep, 2002 | Pubmed ID: 12221130 Ablación láser y microscopía intravital para estudiar la remodelación intestinal Dimitrios Laskaris*1,2, Maria Azkanaz*1,2, Mijke A. de Vreij-Kruidenier3, Doreen van Rijswoud-Ram3, Hendrik A. Messal1,2, Jacco van Rheenen1,2 1Department of Molecular Pathology, The Netherlands Cancer Institute, 2Oncode Institute, 3Animal Laboratory Facility, The Netherlands Cancer Institute JoVE 64756 Biology Microscopía intravital longitudinal con una ventana de imágenes mamarias con tapa reemplazable Larissa Mourao1,2, Marta Ciwinska1,2, Jacco van Rheenen3, Colinda L. G. J. Scheele1,2 1Center for Cancer Biology, VIB (BE), 2Department of Oncology, KU Leuven (BE), 3Netherlands Cancer Institute, Department of Molecular Pathology, Oncode Institute (NL) JoVE 63326 Biology Dendra2 Photoswitching a través de la ventana de imágenes mamarias Bojana Gligorijevic1,2, Dmitriy Kedrin1, Jeffrey E Segall1, John Condeelis1,2, Jacco van Rheenen1,2,3 1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine - Yeshiva University, 2Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine - Yeshiva University, 3Hubrecht Institute-KNAW and University Medical Center Utrecht JoVE 1278 Biology
Ablación láser y microscopía intravital para estudiar la remodelación intestinal Dimitrios Laskaris*1,2, Maria Azkanaz*1,2, Mijke A. de Vreij-Kruidenier3, Doreen van Rijswoud-Ram3, Hendrik A. Messal1,2, Jacco van Rheenen1,2 1Department of Molecular Pathology, The Netherlands Cancer Institute, 2Oncode Institute, 3Animal Laboratory Facility, The Netherlands Cancer Institute JoVE 64756 Biology
Microscopía intravital longitudinal con una ventana de imágenes mamarias con tapa reemplazable Larissa Mourao1,2, Marta Ciwinska1,2, Jacco van Rheenen3, Colinda L. G. J. Scheele1,2 1Center for Cancer Biology, VIB (BE), 2Department of Oncology, KU Leuven (BE), 3Netherlands Cancer Institute, Department of Molecular Pathology, Oncode Institute (NL) JoVE 63326 Biology
Dendra2 Photoswitching a través de la ventana de imágenes mamarias Bojana Gligorijevic1,2, Dmitriy Kedrin1, Jeffrey E Segall1, John Condeelis1,2, Jacco van Rheenen1,2,3 1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine - Yeshiva University, 2Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine - Yeshiva University, 3Hubrecht Institute-KNAW and University Medical Center Utrecht JoVE 1278 Biology