Articles by Jacob Hamilton In JoVE (1) Preparation of Meiotic Chromosome Spreads from Mouse Spermatocytes Other Publications (0) Articles by Jacob Hamilton in JoVE Biology Preparation of Meiotic Chromosome Spreads from Mouse Spermatocytes Ferdusy Dia1, Tierra Strange1, Jenny Liang1, Jacob Hamilton1, Karen M. Berkowitz1,2 1Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, 2Department of Obstetrics & Gynecology, Drexel University College of Medicine Meiosis is the developmental process by which gametes are formed through a single round of DNA replication and two successive rounds of chromosome segregation. Mammalian meiosis can be examined by utilizing a technique to prepare meiotic chromosome spreads. Here, we demonstrate a method of preparing surface-spread nuclei from mouse spermatocytes.
