Articles by Jacob Hamilton in JoVE

• Biology

  
  Preparation of Meiotic Chromosome Spreads from Mouse Spermatocytes Ferdusy Dia¹, Tierra Strange¹, Jenny Liang¹, Jacob Hamilton¹, Karen M. Berkowitz^{1,2 1}Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, ²Department of Obstetrics & Gynecology, Drexel University College of Medicine Meiosis is the developmental process by which gametes are formed through a single round of DNA replication and two successive rounds of chromosome segregation. Mammalian meiosis can be examined by utilizing a technique to prepare meiotic chromosome spreads. Here, we demonstrate a method of preparing surface-spread nuclei from mouse spermatocytes.