Other Publications (1)
Articles by Jennifer G. Nelson-Brantley in JoVE
A Protocol for Decellularizing Mouse Cochleae for Inner Ear Tissue Engineering Christopher A. Neal1, Jennifer G. Nelson-Brantley1, Michael S. Detamore2, Hinrich Staecker1, Adam J. Mellott3 1Department of Otolaryngology, University of Kansas Medical Center, 2Stephenson School of Biomedical Engineering, University of Oklahoma, 3Department of Plastic Surgery, University of Kansas Medical Center The goal of this protocol is to demonstrate an effective method to decellularize and decalcify mouse cochleae for utilization as scaffolds for tissue engineering applications.
Other articles by Jennifer G. Nelson-Brantley on PubMed
Exploiting Decellularized Cochleae As Scaffolds for Inner Ear Tissue Engineering Stem Cell Research & Therapy. | Pubmed ID: 28241887 Use of decellularized tissues has become popular in tissue engineering applications as the natural extracellular matrix can provide necessary physical cues that help induce the restoration and development of functional tissues. In relation to cochlear tissue engineering, the question of whether decellularized cochlear tissue can act as a scaffold and support the incorporation of exogenous cells has not been addressed. Investigators have explored the composition of the cochlear extracellular matrix and developed multiple strategies for decellularizing a variety of different tissues; however, no one has investigated whether decellularized cochlear tissue can support implantation of exogenous cells.