László Virág Department of Medical Chemistry, Faculty of Medicine University of Debrecen Biography Publications Institution JoVE Articles László Virág has not added a biography. If you are László Virág and would like to personalize this page please email our Author Liaison for assistance. Publications PARP14 Contributes to the Development of the Tumor-Associated Macrophage Phenotype International Journal of Molecular Sciences. Mar, 2024 | Pubmed ID: 38612413 Selective Inhibition of Cardiac Late Na Current Is Based on Fast Offset Kinetics of the Inhibitor Biomedicines. Aug, 2023 | Pubmed ID: 37760824 Adenosine A Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages Current Issues in Molecular Biology. Jun, 2023 | Pubmed ID: 37367064 OGG1 Inhibition Reduces Acinar Cell Injury in a Mouse Model of Acute Pancreatitis Biomedicines. Oct, 2022 | Pubmed ID: 36289805 Tricetin Reduces Inflammation and Acinar Cell Injury in Cerulein-Induced Acute Pancreatitis: The Role of Oxidative Stress-Induced DNA Damage Signaling Biomedicines. Jun, 2022 | Pubmed ID: 35740393 Cathepsin D Interacts with Adenosine A Receptors in Mouse Macrophages to Modulate Cell Surface Localization and Inflammatory Signaling The Journal of Biological Chemistry. May, 2022 | Pubmed ID: 35367412 The Multitargeted Receptor Tyrosine Kinase Inhibitor Sunitinib Induces Resistance of HER2 Positive Breast Cancer Cells to Trastuzumab-mediated ADCC Cancer Immunology, Immunotherapy : CII. Sep, 2022 | Pubmed ID: 35066605 Blood Flow Restriction During the Resting Periods of High-intensity Resistance Training Does Not Alter Performance but Decreases MIR-1 and MIR-133A Levels in Human Skeletal Muscle Sports Medicine and Health Science. Mar, 2021 | Pubmed ID: 35782677 Late Na Current Is [Ca]-Dependent in Canine Ventricular Myocytes Pharmaceuticals (Basel, Switzerland). Nov, 2021 | Pubmed ID: 34832924 NMNAT1 Is a Survival Factor in Actinomycin D-Induced Osteosarcoma Cell Death International Journal of Molecular Sciences. Aug, 2021 | Pubmed ID: 34445574 Mexiletine-like Cellular Electrophysiological Effects of GS967 in Canine Ventricular Myocardium Scientific Reports. May, 2021 | Pubmed ID: 33953276 The PARP Enzyme Family and the Hallmarks of Cancer Part 2: Hallmarks Related to Cancer Host Interactions Cancers. Apr, 2021 | Pubmed ID: 33923319 The PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks Cancers. Apr, 2021 | Pubmed ID: 33922595 Caspase-9 Acts As a Regulator of Necroptotic Cell Death The FEBS Journal. Nov, 2021 | Pubmed ID: 33899329 Poly(ADP-Ribose) Polymerase 1 Promotes Inflammation and Fibrosis in a Mouse Model of Chronic Pancreatitis International Journal of Molecular Sciences. Mar, 2021 | Pubmed ID: 33808340 High-content Screening Identifies Inhibitors of Oxidative Stress-induced Parthanatos: Cytoprotective and Anti-inflammatory Effects of Ciclopirox British Journal of Pharmacology. Mar, 2021 | Pubmed ID: 33332573 Editorial: Perspectives of Antiarrhythmic Drug Therapy: Disappointing Past, Current Efforts, and Faint Hopes Frontiers in Pharmacology. 2020 | Pubmed ID: 32792952 How Do Post-Translational Modifications Influence the Pathomechanistic Landscape of Huntington's Disease? A Comprehensive Review International Journal of Molecular Sciences. Jun, 2020 | Pubmed ID: 32560122 Targeting Nuclear NAD Synthesis Inhibits DNA Repair, Impairs Metabolic Adaptation and Increases Chemosensitivity of U-2OS Osteosarcoma Cells Cancers. May, 2020 | Pubmed ID: 32392755 The Proteasome Activator PA200 Regulates Expression of Genes Involved in Cell Survival Upon Selective Mitochondrial Inhibition in Neuroblastoma Cells Journal of Cellular and Molecular Medicine. Jun, 2020 | Pubmed ID: 32368861 Late Sodium Current in Human, Canine and Guinea Pig Ventricular Myocardium Journal of Molecular and Cellular Cardiology. Feb, 2020 | Pubmed ID: 31958464 Poly(ADP-ribose) Polymerase-1 Depletion Enhances the Severity of Inflammation in an Imiquimod-induced Model of Psoriasis Experimental Dermatology. Jan, 2020 | Pubmed ID: 31755591 Implication of Frequency-dependent Protocols in Antiarrhythmic and Proarrhythmic Drug Testing Progress in Biophysics and Molecular Biology. Nov, 2020 | Pubmed ID: 31726065 Spilanthol Inhibits Inflammatory Transcription Factors and INOS Expression in Macrophages and Exerts Anti-inflammatory Effects in Dermatitis and Pancreatitis International Journal of Molecular Sciences. Sep, 2019 | Pubmed ID: 31484391 Lithocholic Acid, a Metabolite of the Microbiome, Increases Oxidative Stress in Breast Cancer Cancers. Aug, 2019 | Pubmed ID: 31461945 Self-defense of Macrophages Against Oxidative Injury: Fighting for Their Own Survival Redox Biology. Sep, 2019 | Pubmed ID: 31279985 Programmed Necrotic Cell Death of Macrophages: Focus on Pyroptosis, Necroptosis, and Parthanatos Redox Biology. Sep, 2019 | Pubmed ID: 31212216 PARP1-LSD1 Functional Interplay Controls Transcription of SOD2 That Protects Human Pro-inflammatory Macrophages from Death Under an Oxidative Condition Free Radical Biology & Medicine. Feb, 2019 | Pubmed ID: 30529301 LPS Protects Macrophages from AIF-independent Parthanatos by Downregulation of PARP1 Expression, Induction of SOD2 Expression, and a Metabolic Shift to Aerobic Glycolysis Free Radical Biology & Medicine. Feb, 2019 | Pubmed ID: 30502458 Redox Profiling Reveals Clear Differences Between Molecular Patterns of Wound Fluids from Acute and Chronic Wounds Oxidative Medicine and Cellular Longevity. 2018 | Pubmed ID: 30581533 PARP1 Promoter Links Cell Cycle Progression with Adaptation to Oxidative Environment Redox Biology. Sep, 2018 | Pubmed ID: 29886395 Redox Control of Cancer Cell Destruction Redox Biology. Jun, 2018 | Pubmed ID: 29477046 Diverse Effect of BMP-2 Homodimer on Mesenchymal Progenitors of Different Origin Human Cell. Apr, 2018 | Pubmed ID: 29442285 Downregulation of PARP1 Transcription by CDK4/6 Inhibitors Sensitizes Human Lung Cancer Cells to Anticancer Drug-induced Death by Impairing OGG1-dependent Base Excision Repair Redox Biology. May, 2018 | Pubmed ID: 29306194 PARP1 Facilitates EP300 Recruitment to the Promoters of the Subset of RBL2-dependent Genes Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms. Dec, 2017 | Pubmed ID: 29313809 A Adenosine Receptors Control Pancreatic Dysfunction in High-fat-diet-induced Obesity FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2017 | Pubmed ID: 28765173 The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments PloS One. 2016 | Pubmed ID: 27832106 Autophagy Requires Poly(adp-ribosyl)ation-dependent AMPK Nuclear Export Cell Death and Differentiation. Dec, 2016 | Pubmed ID: 27689873 Diabetes-induced Oxidative Stress in the Vitreous Humor Redox Biology. Oct, 2016 | Pubmed ID: 27454767 The PARP Inhibitor PJ-34 Sensitizes Cells to UVA-induced Phototoxicity by a PARP Independent Mechanism Mutation Research. Aug, 2016 | Pubmed ID: 27427773 Mitochondrial Poly(ADP-ribose) Polymerase: The Wizard of Oz at Work Free Radical Biology & Medicine. Nov, 2016 | Pubmed ID: 26964508 High Throughput Screening Identifies a Novel Compound Protecting Cardiomyocytes from Doxorubicin-Induced Damage Oxidative Medicine and Cellular Longevity. 2015 | Pubmed ID: 26137186 Poly(ADP-ribose) in the Bone: from Oxidative Stress Signal to Structural Element Free Radical Biology & Medicine. May, 2015 | Pubmed ID: 25660995 Poly(ADP) Ribose Polymerase-1 Ablation Alters Eicosanoid and Docosanoid Signaling and Metabolism in a Murine Model of Contact Hypersensitivity Molecular Medicine Reports. Apr, 2015 | Pubmed ID: 25482287 Protein Phosphatase-1 is Involved in the Maintenance of Normal Homeostasis and in UVA Irradiation-induced Pathological Alterations in HaCaT Cells and in Mouse Skin Biochimica Et Biophysica Acta. Jan, 2015 | Pubmed ID: 25446992 Inputs and Outputs of Poly(ADP-ribosyl)ation: Relevance to Oxidative Stress Redox Biology. 2014 | Pubmed ID: 25460733 The Role of P38 Signaling and Poly(ADP-ribosyl)ation-induced Metabolic Collapse in the Osteogenic Differentiation-coupled Cell Death Pathway Free Radical Biology & Medicine. Nov, 2014 | Pubmed ID: 25078118 Activation of Poly(ADP-ribose) Polymerase-1 Delays Wound Healing by Regulating Keratinocyte Migration and Production of Inflammatory Mediators Molecular Medicine (Cambridge, Mass.). Aug, 2014 | Pubmed ID: 25014793 Deletion of PARP-2 Induces Hepatic Cholesterol Accumulation and Decrease in HDL Levels Biochimica Et Biophysica Acta. Apr, 2014 | Pubmed ID: 24365238 A2B Adenosine Receptors Prevent Insulin Resistance by Inhibiting Adipose Tissue Inflammation Via Maintaining Alternative Macrophage Activation Diabetes. Mar, 2014 | Pubmed ID: 24194503 Glycogen Phosphorylase Inhibitor N-(3,5-dimethyl-Benzoyl)-N'-(β-D-glucopyranosyl)urea Improves Glucose Tolerance Under Normoglycemic and Diabetic Conditions and Rearranges Hepatic Metabolism PloS One. 2013 | Pubmed ID: 23936011 Adenosine Augments IL-10-induced STAT3 Signaling in M2c Macrophages Journal of Leukocyte Biology. Dec, 2013 | Pubmed ID: 23922379 Increased DNA Damage in Progression of COPD: a Response by Poly(ADP-ribose) Polymerase-1 PloS One. 2013 | Pubmed ID: 23894640 Ionic Mechanisms Limiting Cardiac Repolarization Reserve in Humans Compared to Dogs The Journal of Physiology. Sep, 2013 | Pubmed ID: 23878377 50Years of Poly(ADP-ribosyl)ation Molecular Aspects of Medicine. Dec, 2013 | Pubmed ID: 23727362 Role of Poly(ADP-ribosyl)ation in a 'two-hit' Model of Hypoxia and Oxidative Stress in Human A549 Epithelial Cells in Vitro International Journal of Molecular Medicine. Aug, 2013 | Pubmed ID: 23722590 Cytoprotective Dibenzoylmethane Derivatives Protect Cells from Oxidative Stress-induced Necrotic Cell Death Pharmacological Research. Jun, 2013 | Pubmed ID: 23523665 In Vivo Application of a Small Molecular Weight Antifungal Protein of Penicillium Chrysogenum (PAF) Toxicology and Applied Pharmacology. May, 2013 | Pubmed ID: 23466426 Poly(ADP-ribose) Signaling in Cell Death Molecular Aspects of Medicine. Dec, 2013 | Pubmed ID: 23416893 3-Aminobenzamide Protects Primary Human Keratinocytes from UV-induced Cell Death by a Poly(ADP-ribosyl)ation Independent Mechanism Biochimica Et Biophysica Acta. Mar, 2013 | Pubmed ID: 23246565 Role of Poly(ADP-ribose) Polymerases in the Regulation of Inflammatory Processes FEBS Letters. Nov, 2012 | Pubmed ID: 23022557 Poly(ADP-ribosyl)ation is a Survival Mechanism in Cigarette Smoke-induced and Hydrogen Peroxide-mediated Cell Death Free Radical Biology & Medicine. Nov, 2012 | Pubmed ID: 22964577 Hydrogen Peroxide-induced Poly(ADP-ribosyl)ation Regulates Osteogenic Differentiation-associated Cell Death Free Radical Biology & Medicine. Oct, 2012 | Pubmed ID: 22940495 Poly(ADP-ribose) Polymerase-2: Emerging Transcriptional Roles of a DNA-repair Protein Cellular and Molecular Life Sciences : CMLS. Dec, 2012 | Pubmed ID: 22581363 Poly(ADP-ribose) in the Skin and in Melanomas Histology and Histopathology. May, 2012 | Pubmed ID: 22419029 Adenosine Augments IL-10 Production by Microglial Cells Through an A2B Adenosine Receptor-mediated Process Journal of Immunology (Baltimore, Md. : 1950). Jan, 2012 | Pubmed ID: 22116830 A Multiscale Investigation of Repolarization Variability and Its Role in Cardiac Arrhythmogenesis Biophysical Journal. Dec, 2011 | Pubmed ID: 22208187 Poly(ADP-ribose) Polymerase-2 Depletion Reduces Doxorubicin-induced Damage Through SIRT1 Induction Cardiovascular Research. Dec, 2011 | Pubmed ID: 21921080 Ecto-5'-nucleotidase (CD73) Decreases Mortality and Organ Injury in Sepsis Journal of Immunology (Baltimore, Md. : 1950). Oct, 2011 | Pubmed ID: 21918191 Genetic Ablation of PARP-1 Protects Against Oxazolone-induced Contact Hypersensitivity by Modulating Oxidative Stress The Journal of Investigative Dermatology. Nov, 2010 | Pubmed ID: 20613774 Reverse Rate-dependent Changes Are Determined by Baseline Action Potential Duration in Mammalian and Human Ventricular Preparations Basic Research in Cardiology. May, 2010 | Pubmed ID: 20127488 Dual Role of Poly(ADP-ribose) Glycohydrolase in the Regulation of Cell Death in Oxidatively Stressed A549 Cells FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Oct, 2009 | Pubmed ID: 19571039 Reverse Rate Dependency is an Intrinsic Property of Canine Cardiac Preparations Cardiovascular Research. Nov, 2009 | Pubmed ID: 19556280 Protein Kinase C Protects from DNA Damage-induced Necrotic Cell Death by Inhibiting Poly(ADP-ribose) Polymerase-1 FEBS Letters. May, 2008 | Pubmed ID: 18439913 A2A Adenosine Receptors and C/EBPbeta Are Crucially Required for IL-10 Production by Macrophages Exposed to Escherichia Coli Blood. Oct, 2007 | Pubmed ID: 17525287 Protein Tyrosine Nitration and Poly(ADP-ribose) Polymerase Activation in N-methyl-N-nitro-N-nitrosoguanidine-treated Thymocytes: Implication for Cytotoxicity Toxicology Letters. May, 2007 | Pubmed ID: 17428624 Oxidative Stress-induced Poly(ADP-ribosyl)ation in Chick Limb Bud-derived Chondrocytes International Journal of Molecular Medicine. Apr, 2007 | Pubmed ID: 17334635 Structure and Function of Poly(ADP-ribose) Polymerase-1: Role in Oxidative Stress-related Pathologies Current Vascular Pharmacology. Jul, 2005 | Pubmed ID: 16026317 Gallotannin Inhibits the Expression of Chemokines and Inflammatory Cytokines in A549 Cells Molecular Pharmacology. Sep, 2005 | Pubmed ID: 15976037 Poly(ADP-ribosyl)ation in Asthma and Other Lung Diseases Pharmacological Research. Jul, 2005 | Pubmed ID: 15911336 Selective Inhibition of Sodium-calcium Exchanger by SEA-0400 Decreases Early and Delayed After Depolarization in Canine Heart British Journal of Pharmacology. Dec, 2004 | Pubmed ID: 15504749 Cytoprotective Effect of Gallotannin in Oxidatively Stressed HaCaT Keratinocytes: the Role of Poly(ADP-ribose) Metabolism Experimental Dermatology. Mar, 2004 | Pubmed ID: 14987257 Effects of Poly(ADP-ribose) Polymerase Inhibition on Inflammatory Cell Migration in a Murine Model of Asthma Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. Mar, 2004 | Pubmed ID: 14976461 Role of Intracellular Calcium Mobilization and Cell-density-dependent Signaling in Oxidative-stress-induced Cytotoxicity in HaCaT Keratinocytes The Journal of Investigative Dermatology. Jul, 2003 | Pubmed ID: 12839568 Peroxynitrite-induced Cytotoxicity: Mechanism and Opportunities for Intervention Toxicology Letters. Apr, 2003 | Pubmed ID: 12676457 Nitric Oxide-peroxynitrite-poly(ADP-ribose) Polymerase Pathway in the Skin Experimental Dermatology. Jun, 2002 | Pubmed ID: 12102657 Detection of Poly(ADP-ribose) Polymerase Activation in Oxidatively Stressed Cells and Tissues Using Biotinylated NAD Substrate The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Jan, 2002 | Pubmed ID: 11748298 כימות ציטוטוקסיות תאית תלוית נוגדנים במודל ספרואידי גידול: יישום לגילוי תרופות Isotta Sturniolo1,2, Csongor Váróczy1,3, Ákos Máté Bede1,3, Csaba Hegedűs1, Máté Á. Demény1,4, László Virág1,4 1Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 2Doctoral School of Molecular Medicine, University of Debrecen, 3National Academy of Scientist Education, 4HUN-REN-DE Cell Biology and Signaling Research Group JoVE 65922 Cancer Research בדיקת סינון תוכן גבוהה לזיהוי תרכובות ציטוטוקסיות תאיות תלויות נוגדנים Eliza Guti*1,2, Ákos Máté Bede*1,3, Csongor Váróczy*1,3, Csaba Hegedűs1, Máté Á. Demény1,4, László Virág1,4 1Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 2Doctoral School of Molecular Medicine, University of Debrecen, 3National Academy of Scientist Education, University of Debrecen, 4ELKH-DE Cell Biology and Signaling Research Group JoVE 64485 Cancer Research
כימות ציטוטוקסיות תאית תלוית נוגדנים במודל ספרואידי גידול: יישום לגילוי תרופות Isotta Sturniolo1,2, Csongor Váróczy1,3, Ákos Máté Bede1,3, Csaba Hegedűs1, Máté Á. Demény1,4, László Virág1,4 1Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 2Doctoral School of Molecular Medicine, University of Debrecen, 3National Academy of Scientist Education, 4HUN-REN-DE Cell Biology and Signaling Research Group JoVE 65922 Cancer Research
בדיקת סינון תוכן גבוהה לזיהוי תרכובות ציטוטוקסיות תאיות תלויות נוגדנים Eliza Guti*1,2, Ákos Máté Bede*1,3, Csongor Váróczy*1,3, Csaba Hegedűs1, Máté Á. Demény1,4, László Virág1,4 1Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 2Doctoral School of Molecular Medicine, University of Debrecen, 3National Academy of Scientist Education, University of Debrecen, 4ELKH-DE Cell Biology and Signaling Research Group JoVE 64485 Cancer Research
