Articles by Mehdi Bin Samad in JoVE
Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials Mehdi Bin Samad1, Krishnaiah Maddeboina1, Nathalia Rodrigues de Almeida1, Martin Conda-Sheridan1 1Department of Pharmaceutical Sciences, University of Nebraska Medical Center The synthesis of polyamine-based peptide amphiphiles (PPAs) is a significant challenge due to the presence of multiple amine nitrogens, which requires judicious use of protecting groups to mask these reactive functionalities. In this paper, we describe a facile method for the preparation of these new class of self-assembling molecules.
Other articles by Mehdi Bin Samad on PubMed
Developing Polyamine-Based Peptide Amphiphiles with Tunable Morphology and Physicochemical Properties Macromolecular Bioscience. | Pubmed ID: 28509362 The ability to tune supramolecular properties such as size, morphology, or metabolic stability is of paramount importance in the field of supramolecular chemistry. Peptide amphiphiles (PAs) are a family of functional self-assembling biomaterials that have garnered widespread attention due to their broad applicability in medicine. PAs are generally comprised of an amino acid sequence connected to lipid tail(s) allowing them to self-assemble into supramolecular structures with diverse morphologies. Herein, this study describes the synthesis of a new class of polyamine-based "hybrid" PAs (PPAs) as novel self-assembling systems. The described molecules possess diverse polyamine head groups with the goal of tuning physicochemical properties. The findings indicate that small changes in the polyamine head groups result in altered PPA morphologies (nanofibers, micelles, nanoworms). The PPAs present a wide range of physicochemical characteristics, show superior resistance to aggregation, a diverse metabolic profile, and varied assembling kinetics. Most of the PPAs do not show toxicity in the human cells lines evaluated. The PPAs described herein hold promising potential as a safe and nontoxic option for drug delivery, targeting, and tissue engineering applications.
-Gingerol, from Zingiber Officinale, Potentiates GLP-1 Mediated Glucose-stimulated Insulin Secretion Pathway in Pancreatic β-cells and Increases RAB8/RAB10-regulated Membrane Presentation of GLUT4 Transporters in Skeletal Muscle to Improve Hyperglycemia in Lepr Type 2 Diabetic Mice BMC Complementary and Alternative Medicine. | Pubmed ID: 28793909 -Gingerol, a major component of Zingiber officinale, was previously reported to ameliorate hyperglycemia in type 2 diabetic mice. Endocrine signaling is involved in insulin secretion and is perturbed in db/db Type-2 diabetic mice. -Gingerol was reported to restore the disrupted endocrine signaling in rodents. In this current study on Lepr diabetic mice, we investigated the involvement of endocrine pathway in the insulin secretagogue activity of -Gingerol and the mechanism(s) through which -Gingerol ameliorates hyperglycemia.
PEG Modification of Amorfrutin B from Amorpha Fructicosa Increases Gastric Absorption, Circulation Half-life and Glucose Uptake by T3T-L1 Adipocytes Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. | Pubmed ID: 28866418 Through a simple PEG-conjugation of the natural product Amorfrutin B, we enhanced its pharmacokinetic profile. The PEGylated molecule displayed significantly improved gastrointestinal absorption (p