Robert J. Levy Division of Cardiology, Department of Pediatrics The Children's Hospital of Philadelphia Biography Publications Institution JoVE Articles Robert J. Levy has not added a biography. If you are Robert J. Levy and would like to personalize this page please email our Author Liaison for assistance. Publications Real-time Analysis of Composite Magnetic Nanoparticle Disassembly in Vascular Cells and Biomimetic Media Proceedings of the National Academy of Sciences of the United States of America. Mar, 2014 | Pubmed ID: 24591603 Endothelial Targeting of Nanocarriers Loaded with Antioxidant Enzymes for Protection Against Vascular Oxidative Stress and Inflammation Biomaterials. Apr, 2014 | Pubmed ID: 24480537 The Susceptibility of Bioprosthetic Heart Valve Leaflets to Oxidation Biomaterials. Feb, 2014 | Pubmed ID: 24360721 Modulation of NO and ROS Production by AdiNOS Transduced Vascular Cells Through Supplementation with L-Arg and BH4: Implications for Gene Therapy of Restenosis Atherosclerosis. Sep, 2013 | Pubmed ID: 23958248 Intracellular Signaling Mechanisms Associated with CD47 Modified Surfaces Biomaterials. Nov, 2013 | Pubmed ID: 23948164 Adenoviral Vector Tethering to Metal Surfaces Via Hydrolyzable Cross-linkers for the Modulation of Vector Release and Transduction Biomaterials. Sep, 2013 | Pubmed ID: 23777912 Anchoring of Self-assembled Plasmid DNA/anti-DNA Antibody/cationic Lipid Micelles on Bisphosphonate-modified Stent for Cardiovascular Gene Delivery International Journal of Nanomedicine. 2013 | Pubmed ID: 23687446 Site-specific Gene Delivery to Stented Arteries Using Magnetically Guided Zinc Oleate-based Nanoparticles Loaded with Adenoviral Vectors FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2013 | Pubmed ID: 23407712 Antioxidant Enzymes Reduce DNA Damage and Early Activation of Valvular Interstitial Cells in Aortic Valve Sclerosis Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2013 | Pubmed ID: 23241403 Blood Flow Reprograms Lymphatic Vessels to Blood Vessels The Journal of Clinical Investigation. Jun, 2012 | Pubmed ID: 22622036 Diminished Adhesion and Activation of Platelets and Neutrophils with CD47 Functionalized Blood Contacting Surfaces Biomaterials. Aug, 2012 | Pubmed ID: 22613135 Formulation and in Vitro Characterization of Composite Biodegradable Magnetic Nanoparticles for Magnetically Guided Cell Delivery Pharmaceutical Research. May, 2012 | Pubmed ID: 22274555 Immobilization of Gene Vectors on Bisphosphonate-mediated Gene-eluting Metal Stents Using Antibody for Localized Gene Delivery Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2011 | Pubmed ID: 22195832 Triglycidyl Amine Crosslinking Combined with Ethanol Inhibits Bioprosthetic Heart Valve Calcification The Annals of Thoracic Surgery. Sep, 2011 | Pubmed ID: 21871270 Aortic Valve Cyclic Stretch Causes Increased Remodeling Activity and Enhanced Serotonin Receptor Responsiveness The Annals of Thoracic Surgery. Jul, 2011 | Pubmed ID: 21718840 The Effect of CD47 Modified Polymer Surfaces on Inflammatory Cell Attachment and Activation Biomaterials. Jul, 2011 | Pubmed ID: 21429575 Micropatterning of Three-dimensional Electrospun Polyurethane Vascular Grafts Acta Biomaterialia. Nov, 2010 | Pubmed ID: 20601235 CD47-dependent Molecular Mechanisms of Blood Outgrowth Endothelial Cell Attachment on Cholesterol-modified Polyurethane Biomaterials. Sep, 2010 | Pubmed ID: 20538335 Endothelial Delivery of Antioxidant Enzymes Loaded into Non-polymeric Magnetic Nanoparticles Journal of Controlled Release : Official Journal of the Controlled Release Society. Aug, 2010 | Pubmed ID: 20483366 Targeting Stents with Local Delivery of Paclitaxel-loaded Magnetic Nanoparticles Using Uniform Fields Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20404175 Prevention of Polyurethane Oxidative Degradation with Phenolic Antioxidants Covalently Attached to the Hard Segments: Structure-function Relationships Journal of Biomedical Materials Research. Part A. Sep, 2010 | Pubmed ID: 20306526 Site-specific Gene Therapy for Cardiovascular Disease Current Opinion in Drug Discovery & Development. Mar, 2010 | Pubmed ID: 20205054 Biomechanical and Biologic Effects of Meniscus Stabilization Using Triglycidyl Amine Journal of Biomedical Materials Research. Part A. Apr, 2010 | Pubmed ID: 19557790 Analytical Chemistry: The Matrix Neutralized Nature. Oct, 2009 | Pubmed ID: 19829362 Fenfluramine Disrupts the Mitral Valve Interstitial Cell Response to Serotonin The American Journal of Pathology. Sep, 2009 | Pubmed ID: 19679875 SnapShot: Calcification of Bioprosthetic Heart Valves Biomaterials. Sep, 2009 | Pubmed ID: 19623686 Magnetically Responsive Biodegradable Nanoparticles Enhance Adenoviral Gene Transfer in Cultured Smooth Muscle and Endothelial Cells Molecular Pharmaceutics. Sep-Oct, 2009 | Pubmed ID: 19496618 Site-specific Analgesia with Sustained Release Liposomes Proceedings of the National Academy of Sciences of the United States of America. Apr, 2009 | Pubmed ID: 19416926 Local Delivery of Gene Vectors from Bare-metal Stents by Use of a Biodegradable Synthetic Complex Inhibits In-stent Restenosis in Rat Carotid Arteries Circulation. Apr, 2008 | Pubmed ID: 18413497 Immobilization of Plasmid DNA on an Anti-DNA Antibody Modified Coronary Stent for Intravascular Site-specific Gene Therapy The Journal of Gene Medicine. Apr, 2008 | Pubmed ID: 18213735 High Field Gradient Targeting of Magnetic Nanoparticle-loaded Endothelial Cells to the Surfaces of Steel Stents Proceedings of the National Academy of Sciences of the United States of America. Jan, 2008 | Pubmed ID: 18182491 In Vivo Biomechanical Assessment of Triglycidylamine Crosslinked Pericardium Biomaterials. Dec, 2007 | Pubmed ID: 17822757 Magnetically Driven Plasmid DNA Delivery with Biodegradable Polymeric Nanoparticles FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2007 | Pubmed ID: 17403937 Biological Stability of Polyurethane Modified with Covalent Attachment of Di-tert-butyl-phenol Journal of Biomedical Materials Research. Part A. Sep, 2007 | Pubmed ID: 17370325 Transforming Growth Factor-beta1 Mechanisms in Aortic Valve Calcification: Increased Alkaline Phosphatase and Related Events The Annals of Thoracic Surgery. Mar, 2007 | Pubmed ID: 17307438 Mechanisms of the in Vivo Inhibition of Calcification of Bioprosthetic Porcine Aortic Valve Cusps and Aortic Wall with Triglycidylamine/mercapto Bisphosphonate Biomaterials. Feb, 2007 | Pubmed ID: 17027944 [Animal Study of Intravascular Gene Therapy Based on Polyurethane Implantable Devices] Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae. Oct, 2006 | Pubmed ID: 17121231 In-vivo Dynamic Deformation of the Mitral Valve Anterior Leaflet The Annals of Thoracic Surgery. Oct, 2006 | Pubmed ID: 16996935 Adenoviral Gene Vector Tethering to Nanoparticle Surfaces Results in Receptor-independent Cell Entry and Increased Transgene Expression Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2006 | Pubmed ID: 16807119 Prevention of Oxidative Degradation of Polyurethane by Covalent Attachment of Di-tert-butylphenol Residues Journal of Biomedical Materials Research. Part A. Sep, 2006 | Pubmed ID: 16736485 Surface Heparinization of Polyurethane Via Bromoalkylation of Hard Segment Nitrogens Biomacromolecules. Jan, 2006 | Pubmed ID: 16398531 Serotonin Transporter Mechanisms and Cardiac Disease Circulation. Jan, 2006 | Pubmed ID: 16391164 Bisphosphonate-mediated Gene Vector Delivery from the Metal Surfaces of Stents Proceedings of the National Academy of Sciences of the United States of America. Jan, 2006 | Pubmed ID: 16371477 Cholesterol-modified Polyurethane Valve Cusps Demonstrate Blood Outgrowth Endothelial Cell Adhesion Post-seeding in Vitro and in Vivo The Annals of Thoracic Surgery. Jan, 2006 | Pubmed ID: 16368333 Site Specific Gene Delivery in the Cardiovascular System Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2005 | Pubmed ID: 16298010 Posttranslational Control of a Cardiac Ion Channel Transgene in Vivo: Clarithromycin-hMiRP1-Q9E Interactions Human Gene Therapy. Jul, 2005 | Pubmed ID: 16000071 Calcification of Tissue Heart Valve Substitutes: Progress Toward Understanding and Prevention The Annals of Thoracic Surgery. Mar, 2005 | Pubmed ID: 15734452 Prevention of Calcification of Bioprosthetic Heart Valve Cusp and Aortic Wall with Ethanol and Aluminum Chloride The Annals of Thoracic Surgery. Mar, 2005 | Pubmed ID: 15734402 Triglycidylamine Crosslinking of Porcine Aortic Valve Cusps or Bovine Pericardium Results in Improved Biocompatibility, Biomechanics, and Calcification Resistance: Chemical and Biological Mechanisms The American Journal of Pathology. Jan, 2005 | Pubmed ID: 15631995 Cholesterol-derivatized Polyurethane: Characterization and Endothelial Cell Adhesion Journal of Biomedical Materials Research. Part A. Feb, 2005 | Pubmed ID: 15625684 Transcription Factor Egr-1 in Calcific Aortic Valve Disease The Journal of Heart Valve Disease. Nov, 2004 | Pubmed ID: 15597579 Modulation of Eomes Activity Alters the Size of the Developing Heart: Implications for in Utero Cardiac Gene Therapy Human Gene Therapy. Sep, 2004 | Pubmed ID: 15353039 Ethanol Inhibition of Porcine Bioprosthetic Heart Valve Cusp Calcification is Enhanced by Reduction with Sodium Borohydride The Journal of Heart Valve Disease. May, 2004 | Pubmed ID: 15222297 Delivery and Expression of PDNA Embedded in Collagen Matrices Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2004 | Pubmed ID: 14980779 Polymer Degradation and in Vitro Release of a Model Protein from Poly(D,L-lactide-co-glycolide) Nano- and Microparticles Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2003 | Pubmed ID: 14499195 Prevention of Polyurethane Valve Cusp Calcification with Covalently Attached Bisphosphonate Diethylamino Moieties Journal of Biomedical Materials Research. Part A. Aug, 2003 | Pubmed ID: 12889009 The Incorporation of an Ion Channel Gene Mutation Associated with the Long QT Syndrome (Q9E-hMiRP1) in a Plasmid Vector for Site-specific Arrhythmia Gene Therapy: in Vitro and in Vivo Feasibility Studies Human Gene Therapy. Jun, 2003 | Pubmed ID: 12828861 Inhibition of Cusp and Aortic Wall Calcification in Ethanol- and Aluminum-treated Bioprosthetic Heart Valves in Sheep: Background, Mechanisms, and Synergism The Journal of Heart Valve Disease. Mar, 2003 | Pubmed ID: 12701794 Calcification Resistance with Aluminum-ethanol Treated Porcine Aortic Valve Bioprostheses in Juvenile Sheep The Annals of Thoracic Surgery. Apr, 2003 | Pubmed ID: 12683574 Progression of Aortic Valve Stenosis: TGF-beta1 is Present in Calcified Aortic Valve Cusps and Promotes Aortic Valve Interstitial Cell Calcification Via Apoptosis The Annals of Thoracic Surgery. Feb, 2003 | Pubmed ID: 12607654 Serotonin Mechanisms in Heart Valve Disease II: the 5-HT2 Receptor and Its Signaling Pathway in Aortic Valve Interstitial Cells The American Journal of Pathology. Dec, 2002 | Pubmed ID: 12466135 Serotonin Mechanisms in Heart Valve Disease I: Serotonin-induced Up-regulation of Transforming Growth Factor-beta1 Via G-protein Signal Transduction in Aortic Valve Interstitial Cells The American Journal of Pathology. Dec, 2002 | Pubmed ID: 12466127 Thymosin Beta4 Regulation, Expression and Function in Aortic Valve Interstitial Cells The Journal of Heart Valve Disease. Sep, 2002 | Pubmed ID: 12358412 Endovascular Microcoil Gene Delivery Using Immobilized Anti-adenovirus Antibody for Vector Tethering Stroke; a Journal of Cerebral Circulation. May, 2002 | Pubmed ID: 11988618 Gene Delivery to Pig Coronary Arteries from Stents Carrying Antibody-tethered Adenovirus Human Gene Therapy. Feb, 2002 | Pubmed ID: 11860711 The Use of the Ex Vivo Chandler Loop Apparatus to Assess the Biocompatibility of Modified Polymeric Blood Conduits Joshua B. Slee1,2, Ivan S. Alferiev1,2, Robert J. Levy1,2, Stanley J. Stachelek1,2 1Division of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, 2University of Pennsylvania Perelman School of Medicine JoVE 51871 Bioengineering Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers Ilia Fishbein1, Scott P. Forbes1, Richard F. Adamo1, Michael Chorny1, Robert J. Levy1, Ivan S. Alferiev1 1Department of Pediatrics, Division of Cardiology, The Children's Hospital of Philadelphia, University of Pennsylvania JoVE 51653 Medicine
The Use of the Ex Vivo Chandler Loop Apparatus to Assess the Biocompatibility of Modified Polymeric Blood Conduits Joshua B. Slee1,2, Ivan S. Alferiev1,2, Robert J. Levy1,2, Stanley J. Stachelek1,2 1Division of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, 2University of Pennsylvania Perelman School of Medicine JoVE 51871 Bioengineering
Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers Ilia Fishbein1, Scott P. Forbes1, Richard F. Adamo1, Michael Chorny1, Robert J. Levy1, Ivan S. Alferiev1 1Department of Pediatrics, Division of Cardiology, The Children's Hospital of Philadelphia, University of Pennsylvania JoVE 51653 Medicine
