Articles by Tobias Niksch in JoVE
Investigations on the Ga(III) Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue Julia Greiser1, Tobias Niksch1, Wolfgang Weigand2, Martin Freesmeyer1 1Clinic of Nuclear Medicine, University Hospital Jena, 2Friedrich Schiller University A procedure for the isolation of EOB-DTPA and subsequent complexation with natural Ga(III) and 68Ga is presented herein, as well as a thorough analysis of all compounds and investigations on labeling efficiency, in vitro stability and the n-octanol/water distribution coefficient of the radiolabeled complex.
Other articles by Tobias Niksch on PubMed
Synthetic Strategies to a Backbone-side Chain Cyclic SHP-1 N-SH2 Ligand Containing N-functionalized Alkyl Phosphotyrosine Protein and Peptide Letters. Jul, 2010 | Pubmed ID: 19747152 The cyclic peptide EGLNc Psi [CON((CH(2))(3)NH)pYNleE(NHCH(2)CO)]L-NH(2) (1) was designed and synthesized according to a native interaction partner of tyrosine phosphatase SHP-1. We introduced N-aminopropyl-phosphotyrosine to enable backbone-side chain cyclization with a glutamic acid derivative as counterpart for cyclization. Different approaches have been compared to find a strategy for the generation of backbone and backbone-side chain cyclic phosphopeptides.
Low-activity 124I-PET/low-dose CT Versus 99mTc-pertechnetate Planar Scintigraphy or 99mTc-pertechnetate Single-photon Emission Computed Tomography of the Thyroid: a Pilot Comparison Clinical Nuclear Medicine. Oct, 2013 | Pubmed ID: 23877506 The standard thyroid functional imaging method, 99mTc-pertechnetate (99mTc-PT) planar scintigraphy, has technical drawbacks decreasing its sensitivity in detecting nodules or anatomical pathology. 124I-PET, lacking these disadvantages and allowing simultaneous CT, may have greater sensitivity for these purposes. We performed a blinded pilot comparison of 124I-PET(/CT) versus 99mTc-PT planar scintigraphy or its cross-sectional enhancement, 99mTc-PT single-photon emission CT (SPECT), in characterizing the thyroid gland with benign disease.