Articles by Toshiharu Shinoka in JoVE
Implantation of Inferior Vena Cava Interposition Graft in Mouse Model Yong-Ung Lee1, Tai Yi1, Shuhei Tara1, Avione Y. Lee1, Narutoshi Hibino1, Toshiharu Shinoka2, Christopher K. Breuer1,3 1Department of Cardiothoracic Surgery, Nationwide Children's Hospital, 3 To improve our knowledge of cellular and molecular neotissue formation, a murine model of the TEVG was recently developed. The grafts were implanted as infrarenal vena cava interposition grafts in C57BL/6 mice. This model achieves similar results to those achieved in our clinical investigation, but over a far shortened time-course.
Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation Yong-Ung Lee1, Tai Yi1, Iyore James1, Shuhei Tara1, Alexander J. Stuber1, Kejal V. Shah1, Avione Y. Lee1, Tadahisa Sugiura1, Narutoshi Hibino2, Toshiharu Shinoka1, Christopher K. Breuer1,3 1 In order to understand the cellular and molecular mechanisms underlying neotissue formation and stenosis development in tissue engineered heart valves, a murine model of heterotopic heart valve transplantation was developed. A pulmonary heart valve was transplanted to recipient using the heterotopic heart transplantation technique.