Willard M. Freeman Genes & Human Disease Research Program Oklahoma Medical Research Foundation Biography Publications Institution JoVE Articles Willard M. Freeman has not added a biography. If you are Willard M. Freeman and would like to personalize this page please email our Author Liaison for assistance. Publications Chromosomal and Gonadal Factors Regulate Microglial Sex Effects in the Aging Brain Brain Research Bulletin. Feb, 2023 | Pubmed ID: 36804773 Isolation of Neuronal Synaptic Membranes by Sucrose Gradient Centrifugation Methods in Molecular Biology (Clifton, N.J.). 2023 | Pubmed ID: 36653629 17α-estradiol, a Lifespan-extending Compound, Attenuates Liver Fibrosis by Modulating Collagen Turnover Rates in Male Mice American Journal of Physiology. Endocrinology and Metabolism. Feb, 2023 | Pubmed ID: 36516471 Translatomic Response of Retinal Müller Glia to Acute and Chronic Stress Neurobiology of Disease. Dec, 2022 | Pubmed ID: 36423879 An RNA-seq Study of the MPFC of Rats with Different Addiction Phenotypes Brain Research Bulletin. Dec, 2022 | Pubmed ID: 36223840 Differential Regulation of Mouse Hippocampal Gene Expression Sex Differences by Chromosomal Content and Gonadal Sex Molecular Neurobiology. Aug, 2022 | Pubmed ID: 35589920 Minimizing the Confounds of Cell-Isolation Techniques on Transcriptomic and Translatomic Profiles of Purified Microglia ENeuro. 2022 | Pubmed ID: 35228310 Scavenging Mitochondrial Hydrogen Peroxide by Peroxiredoxin 3 Overexpression Attenuates Contractile Dysfunction and Muscle Atrophy in a Murine Model of Accelerated Sarcopenia Aging Cell. Mar, 2022 | Pubmed ID: 35199907 Repeated Cocaine or Methamphetamine Treatment Alters Astrocytic CRF2 and GLAST Expression in the Ventral Midbrain Addiction Biology. Mar, 2022 | Pubmed ID: 34825430 The NOTCH3 Downstream Target HEYL Is Required for Efficient Human Airway Basal Cell Differentiation Cells. Nov, 2021 | Pubmed ID: 34831437 Many Chronological Aging Clocks Can Be Found Throughout the Epigenome: Implications for Quantifying Biological Aging Aging Cell. Nov, 2021 | Pubmed ID: 34655509 Oklahoma Nathan Shock Aging Center - Assessing the Basic Biology of Aging from Genetics to Protein and Function GeroScience. Oct, 2021 | Pubmed ID: 34606039 Litter Expansion Alters Metabolic Homeostasis in a Sex Specific Manner PloS One. 2021 | Pubmed ID: 34587168 Long-term, Induced Expression of Hand2 in Peripheral Sympathetic Neurons Ameliorates Sarcopenia in Geriatric Mice Journal of Cachexia, Sarcopenia and Muscle. Dec, 2021 | Pubmed ID: 34546662 Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial Cells American Journal of Respiratory Cell and Molecular Biology. Apr, 2021 | Pubmed ID: 33444514 Cellular Hallmarks of Aging Emerge in the Ovary Prior to Primordial Follicle Depletion Mechanisms of Ageing and Development. Mar, 2021 | Pubmed ID: 33383072 Health Benefits Attributed to 17α-estradiol, a Lifespan-extending Compound, Are Mediated Through Estrogen Receptor α ELife. Dec, 2020 | Pubmed ID: 33289482 Inducible Cell-specific Mouse Models for Paired Epigenetic and Transcriptomic Studies of Microglia and Astroglia Communications Biology. Nov, 2020 | Pubmed ID: 33214681 Cooperation Between ETS Transcription Factor ETV1 and Histone Demethylase JMJD1A in Colorectal Cancer International Journal of Oncology. Dec, 2020 | Pubmed ID: 33174020 Female Mice Are Resilient to Age-related Decline of Substantia Nigra Dopamine Neuron Firing Parameters Neurobiology of Aging. Nov, 2020 | Pubmed ID: 32846275 Exercising Your Mind Science (New York, N.Y.). Jul, 2020 | Pubmed ID: 32646988 Opposite Roles of the JMJD1A Interaction Partners MDFI and MDFIC in Colorectal Cancer Scientific Reports. May, 2020 | Pubmed ID: 32457453 Molecular Changes in Transcription and Metabolic Pathways Underlying Muscle Atrophy in the CuZnSOD Null Mouse Model of Sarcopenia GeroScience. Aug, 2020 | Pubmed ID: 32394347 Short-term Calorie Restriction and 17α-Estradiol Administration Elicit Divergent Effects on Proteostatic Processes and Protein Content in Metabolically Active Tissues The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Apr, 2020 | Pubmed ID: 31074767 Mitochondrial Oxidative Stress Impairs Contractile Function but Paradoxically Increases Muscle Mass Via Fibre Branching Journal of Cachexia, Sarcopenia and Muscle. Apr, 2019 | Pubmed ID: 30706998 The Role of DNA Methylation in Epigenetics of Aging Pharmacology & Therapeutics. Mar, 2019 | Pubmed ID: 30419258 Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Feb, 2019 | Pubmed ID: 29893815 Insulin-like Growth Factor Receptor Signaling Regulates Working Memory, Mitochondrial Metabolism, and Amyloid-β Uptake in Astrocytes Molecular Metabolism. Mar, 2018 | Pubmed ID: 29398615 Sexually Divergent DNA Methylation Patterns with Hippocampal Aging Aging Cell. Dec, 2017 | Pubmed ID: 28948711 Functional Changes in the Neural Retina Occur in the Absence of Mitochondrial Dysfunction in a Rodent Model of Diabetic Retinopathy Journal of Neurochemistry. Dec, 2017 | Pubmed ID: 28902411 Role of DNA Methylation in the Dietary Restriction Mediated Cellular Memory GeroScience. Jun, 2017 | Pubmed ID: 28477138 Loss of the Antioxidant Enzyme CuZnSOD (Sod1) Mimics an Age-related Increase in Absolute Mitochondrial DNA Copy Number in the Skeletal Muscle Age (Dordrecht, Netherlands). Aug, 2016 | Pubmed ID: 27444179 Bisulfite Oligonucleotide-capture Sequencing for Targeted Base- and Strand-specific Absolute 5-methylcytosine Quantitation Age (Dordrecht, Netherlands). Jun, 2016 | Pubmed ID: 27091453 CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Jan, 2016 | Pubmed ID: 26786204 Detrimental Effects of Duplicate Reads and Low Complexity Regions on RNA- and ChIP-seq Data BMC Bioinformatics. 2015 | Pubmed ID: 26423047 Hippocampal Subregions Exhibit Both Distinct and Shared Transcriptomic Responses to Aging and Nonneurodegenerative Cognitive Decline The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Nov, 2014 | Pubmed ID: 24994846 Insulin Treatment Normalizes Retinal Neuroinflammation but Not Markers of Synapse Loss in Diabetic Rats Experimental Eye Research. Aug, 2014 | Pubmed ID: 24931083 Integrative Transcriptomic and Proteomic Analysis of Osteocytic Cells Exposed to Fluid Flow Reveals Novel Mechano-sensitive Signaling Pathways Journal of Biomechanics. Jun, 2014 | Pubmed ID: 24720889 Focused, High Accuracy 5-methylcytosine Quantitation with Base Resolution by Benchtop Next-generation Sequencing Epigenetics & Chromatin. 2013 | Pubmed ID: 24279302 Expression of NgR1-antagonizing Proteins Decreases with Aging and Cognitive Decline in Rat Hippocampus Cellular and Molecular Neurobiology. May, 2013 | Pubmed ID: 23525710 Increased Hippocampal NgR1 Signaling Machinery in Aged Rats with Deficits of Spatial Cognition The European Journal of Neuroscience. May, 2013 | Pubmed ID: 23438185 Nanoliposomal Minocycline for Ocular Drug Delivery Nanomedicine : Nanotechnology, Biology, and Medicine. Jan, 2013 | Pubmed ID: 22465498 Protein Biomarkers of Alcohol Abuse Expert Review of Proteomics. Aug, 2012 | Pubmed ID: 22967079 Quantification of Hepatic UDP Glucuronosyltransferase 1A Splice Variant Expression and Correlation of UDP Glucuronosyltransferase 1A1 Variant Expression with Glucuronidation Activity The Journal of Pharmacology and Experimental Therapeutics. Sep, 2012 | Pubmed ID: 22661630 Neuroglial Expression of the MHCI Pathway and PirB Receptor is Upregulated in the Hippocampus with Advanced Aging Journal of Molecular Neuroscience : MN. Sep, 2012 | Pubmed ID: 22562814 Hippocampal Expression of Myelin-associated Inhibitors is Induced with Age-related Cognitive Decline and Correlates with Deficits of Spatial Learning and Memory Journal of Neurochemistry. Apr, 2012 | Pubmed ID: 22269040 The Kinetics of Cardiopulmonary Bypass: a Dual-platform Proteomics Study of Plasma Biomarkers in Pediatric Patients Undergoing Cardiopulmonary Bypass Artificial Organs. Jan, 2012 | Pubmed ID: 22250822 Une Analyse Longitudinale Des Protéines Liées Au Stress Et L'autonomie De La Chronique D'éthanol Chez Les Macaques Cynomolgus En Circulation Alcoholism, Clinical and Experimental Research. Dec, 2011 | Pubmed ID: 22141444 Concurrent Hippocampal Induction of MHC II Pathway Components and Glial Activation with Advanced Aging is Not Correlated with Cognitive Impairment Journal of Neuroinflammation. 2011 | Pubmed ID: 21989322 Circulating IGF1 Regulates Hippocampal IGF1 Levels and Brain Gene Expression During Adolescence The Journal of Endocrinology. Oct, 2011 | Pubmed ID: 21750148 The Hippocampal Neuroproteome with Aging and Cognitive Decline: Past Progress and Future Directions Frontiers in Aging Neuroscience. 2011 | Pubmed ID: 21647399 Age-related Alterations in Retinal Neurovascular and Inflammatory Transcripts Molecular Vision. 2011 | Pubmed ID: 21633715 Chronic Insulin Treatment of Diabetes Does Not Fully Normalize Alterations in the Retinal Transcriptome BMC Medical Genomics. 2011 | Pubmed ID: 21575160 Hippocampal Dysregulation of Synaptic Plasticity-associated Proteins with Age-related Cognitive Decline Neurobiology of Disease. Jul, 2011 | Pubmed ID: 21440628 Altérations De Protéomique De Plasma Chez Les Primates Non Humains Et Les Humains Après Administration Chronique D'alcool The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP). Aug, 2011 | Pubmed ID: 21303580 TPH2 in the Ventral Tegmental Area of the Male Rat Brain Brain Research Bulletin. Apr, 2011 | Pubmed ID: 21272616 Multi-modal Proteomic Analysis of Retinal Protein Expression Alterations in a Rat Model of Diabetic Retinopathy PloS One. 2011 | Pubmed ID: 21249158 Différences Individuelles Dans Le Statut D'hyperlipidémie Et De Vitamine E En Réponse à L'auto-administration D'alcool Chronique Chez Des Singes Macaques Alcoholism, Clinical and Experimental Research. Mar, 2011 | Pubmed ID: 21118275 Application Clinique Pour La Préservation Des Phospho-protéines Grâce à La Stabilisation Des Tissus in Situ Proteome Science. 2010 | Pubmed ID: 21092202 Differences in the BAL Proteome After Klebsiella Pneumoniae Infection in Wild Type and SP-A-/- Mice Proteome Science. 2010 | Pubmed ID: 20565803 Effects of Ischemic Preconditioning and Bevacizumab on Apoptosis and Vascular Permeability Following Retinal Ischemia-reperfusion Injury Investigative Ophthalmology & Visual Science. Nov, 2010 | Pubmed ID: 20554620 Aging Alters the Expression of Neurotransmission-regulating Proteins in the Hippocampal Synaptoproteome Journal of Neurochemistry. Jun, 2010 | Pubmed ID: 20374424 Future Prospects for Biomarkers of Alcohol Consumption and Alcohol-induced Disorders Alcoholism, Clinical and Experimental Research. Jun, 2010 | Pubmed ID: 20374220 Dual-platform Proteomics Study of Plasma Biomarkers in Pediatric Patients Undergoing Cardiopulmonary Bypass Pediatric Research. Jun, 2010 | Pubmed ID: 20308938 Classification Des Abus De L'alcool Par Des Biomarqueurs Protéines Plasmatiques Biological Psychiatry. Aug, 2010 | Pubmed ID: 20299005 Gene Expression Changes in the Medial Prefrontal Cortex and Nucleus Accumbens Following Abstinence from Cocaine Self-administration BMC Neuroscience. 2010 | Pubmed ID: 20187946 Circulating Cytokines As Biomarkers of Alcohol Abuse and Alcoholism Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Mar, 2010 | Pubmed ID: 20020329 The Use of Neuroproteomics in Drug Abuse Research Drug and Alcohol Dependence. Feb, 2010 | Pubmed ID: 19926406 FOXO3a Elicits a Pro-apoptotic Transcription Program and Cellular Response to Human Lung Carcinogen Nicotine-derived Nitrosaminoketone (NNK) Lung Cancer (Amsterdam, Netherlands). Jan, 2010 | Pubmed ID: 19380174 2-D DIGE Identification of Differentially Expressed Heterogeneous Nuclear Ribonucleoproteins and Transcription Factors During Neural Differentiation of Human Embryonic Stem Cells Proteomics. Clinical Applications. Apr, 2009 | Pubmed ID: 21136975 Persistent Proteomic Alterations in the Medial Prefrontal Cortex with Abstinence from Cocaine Self-administration Proteomics. Clinical Applications. Mar, 2009 | Pubmed ID: 20161123 Transcriptomic Comparison of the Retina in Two Mouse Models of Diabetes Journal of Ocular Biology, Diseases, and Informatics. 2009 | Pubmed ID: 20157355 Gene Expression Changes Following Extinction Testing in a Heroin Behavioral Incubation Model BMC Neuroscience. 2009 | Pubmed ID: 19664213 Pediatric Cardiopulmonary Bypass Circuits: a Review of Studies Conducted at the Penn State Pediatric Cardiac Research Laboratories The Journal of Extra-corporeal Technology. Mar, 2009 | Pubmed ID: 19361042 The Impact of Surfactant Protein-A on Ozone-induced Changes in the Mouse Bronchoalveolar Lavage Proteome Proteome Science. 2009 | Pubmed ID: 19323824 The Retinal Proteome in Experimental Diabetic Retinopathy: Up-regulation of Crystallins and Reversal by Systemic and Periocular Insulin Molecular & Cellular Proteomics : MCP. Apr, 2009 | Pubmed ID: 19049959 Gene Expression Profiles in HPV-immortalized Human Cervical Cells Treated with the Nicotine-derived Carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Chemico-biological Interactions. Feb, 2009 | Pubmed ID: 19038236 Age-related Changes in the Expression and Oxidation of Bronchoalveolar Lavage Proteins in the Rat American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2009 | Pubmed ID: 18931054 Human Embryonic and Mesenchymal Stem Cells Express Different Nuclear Proteomes Stem Cells and Development. Jun, 2009 | Pubmed ID: 18821827 Correlating Human and Animal Studies of Cocaine Abuse and Gene Expression Annals of the New York Academy of Sciences. Oct, 2008 | Pubmed ID: 18991951 Diabetes Downregulates Presynaptic Proteins and Reduces Basal Synapsin I Phosphorylation in Rat Retina The European Journal of Neuroscience. Jul, 2008 | Pubmed ID: 18662330 Whole Genome Assessment of the Retinal Response to Diabetes Reveals a Progressive Neurovascular Inflammatory Response BMC Medical Genomics. 2008 | Pubmed ID: 18554398 Twenty-five Years of Quantitative PCR for Gene Expression Analysis BioTechniques. Apr, 2008 | Pubmed ID: 18474036 Heroin Self-administration: II. CNS Gene Expression Following Withdrawal and Cue-induced Drug-seeking Behavior Pharmacology, Biochemistry, and Behavior. Sep, 2008 | Pubmed ID: 18466961 Plasma Biomarkers in Pediatric Patients Undergoing Cardiopulmonary Bypass Pediatric Research. Jun, 2008 | Pubmed ID: 18317239 Persistent Alterations in Mesolimbic Gene Expression with Abstinence from Cocaine Self-administration Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jul, 2008 | Pubmed ID: 17851536 Plasma Proteomics: a Noninvasive Window on Pathology and Pediatric Cardiac Surgery ASAIO Journal (American Society for Artificial Internal Organs : 1992). Sep-Oct, 2006 | Pubmed ID: 16966860 Diabetic Retinopathy: Seeing Beyond Glucose-induced Microvascular Disease Diabetes. Sep, 2006 | Pubmed ID: 16936187 Depletion of Abundant Proteins from Non-human Primate Serum for Biomarker Studies Proteomics. May, 2006 | Pubmed ID: 16619306 APO-AII Est Un Biomarqueur élevé D'auto-administration D'éthanol Chronique De Primates Non Humains Alcohol and Alcoholism (Oxford, Oxfordshire). May-Jun, 2006 | Pubmed ID: 16581821 Transcriptome Analysis of Frontal Cortex in Alcohol-preferring and Nonpreferring Rats Journal of Neuroscience Research. May, 2005 | Pubmed ID: 15846778 Manganese-induced Cytotoxicity in Dopamine-producing Cells Neurotoxicology. Jun, 2004 | Pubmed ID: 15183009 Proteomics for Protein Expression Profiling in Neuroscience Neurochemical Research. Jun, 2004 | Pubmed ID: 15176464 Alterations in Ionotropic Glutamate Receptor Subunits During Binge Cocaine Self-administration and Withdrawal in Rats Journal of Neurochemistry. May, 2004 | Pubmed ID: 15140200 Functional Genomic Analysis in Pain Research Using Hybridization Arrays Methods in Molecular Medicine. 2004 | Pubmed ID: 15131342 Use of Microarray Technologies in Toxicology Research Neurotoxicology. Jun, 2003 | Pubmed ID: 12782098 Systematic Screening of Gene Expression Using a CDNA Macroarray Methods in Molecular Medicine. 2003 | Pubmed ID: 12506701 An Interactive Database of Cocaine-responsive Gene Expression TheScientificWorldJournal. Mar, 2002 | Pubmed ID: 12805995 Induction of GADD45 and GADD153 in Neuroblastoma Cells by Dopamine-induced Toxicity Neurotoxicology. Dec, 2002 | Pubmed ID: 12520757 Repeated Cocaine Self-administration Causes Multiple Changes in Rat Frontal Cortex Gene Expression Neurochemical Research. Oct, 2002 | Pubmed ID: 12462416 Changes in Rat Frontal Cortex Gene Expression Following Chronic Cocaine Brain Research. Molecular Brain Research. Jul, 2002 | Pubmed ID: 12117546 Interrogation par appariement spécifique à la cellule de l’épigénome ovarien et du transcriptome de la souris Sarah R. Ocañas*1,2,3, José V. V. Isola*1,3, Tatiana D. Saccon1, Kevin D. Pham2, Ana J. Chucair-Elliott2, Augusto Schneider4, Willard M. Freeman2,3, Michael B. Stout1,3 1Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, 2Genes & Human Disease Research Program, Oklahoma Medical Research Foundation, 3Oklahoma City Veterans Affairs Medical Center, 4Nutrition College, Federal University of Pelotas JoVE 64765 Biology Ciblé méthylation de l'ADN Analyse par séquençage de nouvelle génération Dustin R. Masser1, David R. Stanford1, Willard M. Freeman1,2 1Department of Physiology, University of Oklahoma College of Medicine, 2Department of Geriatric Medicine, University of Oklahoma College of Medicine Biology
Interrogation par appariement spécifique à la cellule de l’épigénome ovarien et du transcriptome de la souris Sarah R. Ocañas*1,2,3, José V. V. Isola*1,3, Tatiana D. Saccon1, Kevin D. Pham2, Ana J. Chucair-Elliott2, Augusto Schneider4, Willard M. Freeman2,3, Michael B. Stout1,3 1Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, 2Genes & Human Disease Research Program, Oklahoma Medical Research Foundation, 3Oklahoma City Veterans Affairs Medical Center, 4Nutrition College, Federal University of Pelotas JoVE 64765 Biology
Ciblé méthylation de l'ADN Analyse par séquençage de nouvelle génération Dustin R. Masser1, David R. Stanford1, Willard M. Freeman1,2 1Department of Physiology, University of Oklahoma College of Medicine, 2Department of Geriatric Medicine, University of Oklahoma College of Medicine Biology
