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A 3D Blood-Brain Barrier Model Derived from Human Pluripotent Stem-Cells

October 20th, 2023
*1,2,3,4,5, *1,2,3,4,5, 1,2,3,4,5, 1,2,3,4,5, 1,2,3,4,5, 1,2,3,4,5, 1,2,3,4,5, 1,2,3,4,5
1Icahn School of Medicine at Mount Sinai, 2Black Family Stem Cell Institute at Mount Sinai, 3Ronald M. Loeb Center for Alzheimer’s Disease at Mount Sinai, 4Friedman Brain Institute at Mount Sinai, 5Nash Family Department of Neuroscience at Mount Sinai
* These authors contributed equally

Summary
Automatic Translation

Blod-hjerne-barrieren (BBB) spiller en afgørende rolle for at opretholde et stabilt og sundt hjernemiljø. BBB dysfunktion er forbundet med mange neurologiske sygdomme. Vi har udviklet en 3D, stamcelleafledt model af BBB for at undersøge cerebrovaskulær patologi, BBB-integritet, og hvordan BBB ændres af genetik og sygdom.

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