A 3D Blood-Brain Barrier Model Derived from Human Pluripotent Stem-Cells

October 20th, 2023

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Preparing Cells to Assemble a 3D Human-Stem-Cell-Derived In Vitro Blood Brain Barrier (Video) | JoVE

02:05 min

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Constructing the 3D Human-Stem-Cell-Derived In Vitro Blood Brain Barrier (Video) | JoVE

02:08 min

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Camille Goldman*^1,2,3,4,5, Natalie Suhy*^1,2,3,4,5, Jessica E. Schwarz^1,2,3,4,5, Emily Ruth Sartori^1,2,3,4,5, Rikki B. Rooklin^1,2,3,4,5, Braxton R. Schuldt^1,2,3,4,5, Louise A. Mesentier-Louro^1,2,3,4,5, Joel W. Blanchard^1,2,3,4,5

¹Icahn School of Medicine at Mount Sinai, ²Black Family Stem Cell Institute at Mount Sinai, ³Ronald M. Loeb Center for Alzheimer’s Disease at Mount Sinai, ⁴Friedman Brain Institute at Mount Sinai, ⁵Nash Family Department of Neuroscience at Mount Sinai

* These authors contributed equally

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Kan-beyin bariyeri (BBB), istikrarlı ve sağlıklı bir beyin ortamının sürdürülmesinde çok önemli bir role sahiptir. BBB disfonksiyonu birçok nörolojik hastalıkla ilişkilidir. Serebrovasküler patolojiyi, BBB bütünlüğünü ve BBB'nin genetik ve hastalık tarafından nasıl değiştirildiğini araştırmak için BBB'nin 3 boyutlu, kök hücre türevli bir modelini geliştirdik.

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A 3D Blood-Brain Barrier Model Derived from Human Pluripotent Stem-Cells

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