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In vivo Bioluminescence Imaging of Tumor Hypoxia Dynamics of Breast Cancer Brain Metastasis in a Mouse Model

Article DOI: 10.3791/3175-v • 11:02 min • October 3rd, 2011
October 3rd, 2011 •
1, 2, 2, 3, 3, 2, 2
1Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2Department of Radiology, University of Texas Southwestern Medical Center, 3Department of Radiation Oncology, Kyoto University Graduate School of Medicine

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Bioluminescence imaging of hypoxia inducible factor-1α activity is applied to monitor intracranial tumor hypoxia development in a breast cancer brain metastasis mouse model.

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In Vivo Bioluminescence Imaging Tumor Hypoxia Dynamics Breast Cancer Brain Metastasis Mouse Model Malignant Progression Therapeutic Response Intracranial Development Orthotopic Tumors Bioluminescence Imaging (BLI) Luciferase Gene Expression Cancer Research Tumor Growth Treatment Response Reporter Gene Hypoxia Inducible Factor-1α (HIF-1α) Gene Transcription MDA-MB231 Cells HIF-1α Bioluminescence Assay Hypoxic Chamber Photon Flux
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