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Interlinked Macroporous 3D Scaffolds from Microgel Rods

Article DOI: 10.3791/64010-v • 07:32 min • June 16th, 2022
June 16th, 2022 •
1,2, 1,2, 1,2, 1,2,3
1DWI - Leibniz Institute for Interactive Materials, 2Institute for Technical and Macromolecular Chemistry, RWTH Aachen University, 3Institute of Applied Medical Engineering, Department of Advanced Materials for Biomedicine, RWTH Aachen University

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Microgel rods with complementary reactive groups are produced via microfluidics with the ability to interlink in aqueous solution. The anisometric microgels jam and interlink into stable constructs with larger pores compared to spherical-based systems. Microgels modified with GRGDS-PC form macroporous 3D constructs that can be used for cell culture.

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Interlinked Macroporous 3D Scaffolds Microgel Rods Cell-cell Interaction High Aspect Ratio Larger Pores Scaffold Stability Synthetic Material Micropores Scaffolds Endogenous Cells Damaged Tissue Repair Blood Vessel Formation Nutrient Exchange Reduction Of Scaffolded Material Tissue Formation In Vitro Applications In Vivo Applications Microfitic Encapsulation Technique Continuous Production Clogging Prevention Polyethylene Tubes Gas Removal Syringe Pumps
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