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Direct Intrabronchial Administration å forbedre selektiv agent deponering innenfor Mouse Lung

Article DOI: 10.3791/59450-v • 07:10 min • May 20th, 2019
May 20th, 2019 •
1, 1, 1,2, 1
1Department of Medicine, University of Colorado Denver, 2Department of Medicine, Denver Health Medical Center

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Intratrakeal (IT) administrering av eksperimentelle midler hos mus resulterer ofte i asymmetrisk levering til de opp-lungene.  I denne rapporten beskriver vi en direkte intrabronchial (IB) for å kannelerer hver lunge i levende mus ikke-operativt.  Denne tilnærmingen kan brukes til å selektivt administrere agenter til en lunge eller kan tilpasses for å forbedre symmetrisk agent levering til begge lungene.

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Medisin Intratrakeal drypping intrabronchial drypping lunge fibrose bleomycin mus lungeskade
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