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Neuroscience

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JoVE Journal Neuroscience
Intrathekale Lieferung von Antisense Oligonukleotiden im Zentralen Nervensystem der Ratte
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Intrathekale Lieferung von Antisense Oligonukleotiden im Zentralen Nervensystem der Ratte

Article DOI: 10.3791/60274-v • 07:47 min • October 29th, 2019
October 29th, 2019 •
*1, *2, *1, 1, 1, 1, 1
1Biogen, Inc., 2Ionis Pharmaceuticals
* These authors contributed equally

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Hier beschreiben wir eine Methode zur Abgabe von Medikamenten an das zentrale Nervensystem der Ratte, indem wir einen Katheter in den lendenintrathekalen Raum der Wirbelsäule implantieren. Wir konzentrieren uns auf die Lieferung von Antisense-Oligonukleotiden, obwohl diese Methode auch für die Lieferung anderer therapeutischer Modalitäten geeignet ist.

Tags

Neurowissenschaften Ausgabe 152 Antisense-Oligonukleotide Blut-Hirn-Schranke zentrales Nervensystem intrathekale Abgabe Ratte RNA Rückenmark
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