Waiting
Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove
第7章
DNA(脱氧核糖核酸)修复概述
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand…
基础切除修复
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing…
长补基地切除修复
Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining…
核苷酸切除修复
Exposure to mutagens can damage DNA and result in bulky lesions that distort the double-helix structure or impede proper transcription. Damaged DNA…
跨病变DNA(脱氧核糖核酸)聚合酶
Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a…
修复双链断裂
The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves…
DNA(脱氧核糖核酸)损伤会延缓细胞周期
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical…
同源重组
The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One…
重新启动停滞的复制叉
DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the…
基因转换
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the…
换位与重组概述
Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role…
纯DNA(脱氧核糖核酸)转座子
DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism.…
逆转录病毒
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on…
LTR(长末端重复序列)逆转座子
LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less…
非LTR(长末端重复序列)逆转座子
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and…
特定地点的保守重组和相变
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic…
原子力显微镜检查DNA损伤识别核苷酸切除修复
AFM imaging is a powerful technique for the study of protein-DNA interactions. This single molecule method allows the simultaneous resolution of…
rad51 介导的 dna 链交换反应的实时观测
The DNA strand exchange reaction mediated by Rad51 is a critical step of homologous recombination. In this reaction, Rad51 forms a nucleoprotein…
RNA 下一代测序和生物信息学管道, 以识别点对位的表达 Line-1
Long INterspersed Elements-1 (LINEs/L1s) are repetitive elements that can copy and randomly insert in the genome resulting in genomic instability and…

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter