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第10章
细胞特异性基因表达
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same…
表达调节发生在多个步骤
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves…
顺式调控序列
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These…
转录调节剂的合作结合。
Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences…
原核转录激活因子和阻遏物
The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the…
操纵子
Prokaryotes can control gene expression through operons—DNA sequences consisting of regulatory elements and clustered, functionally related…
真核启动子区域
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start…
共同激活因子和共同抑制因子
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in…
真核转录激活因子
Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate…
真核转录抑制剂
Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding…
组合基因控制
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of…
诱导多能干细胞
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific…
主转录调节剂
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often…
表观遗传调控
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases…
基因组印记和遗传
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both…
低细胞染色质免疫沉淀测序分析 Olig2 基因组结合位点在急性纯化 PDGFRα + 细胞中的转录因子鉴定
In mammalian cells, gene transcription is regulated in a cell type specific manner by the interactions of transcriptional factors with genomic DNA.…
大鼠甲基 Seq 平台识别与应力接触相关的表观变化
As genomes of a wider variety of animals become available, there is an increasing need for tools that can capture dynamic epigenetic changes in these…
小鼠肝脏中细胞类型特异性基因表达分析
Liver repopulation after injury is a crucial feature of mammals which prevents immediate organ failure and death after exposure of environmental…

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