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Спираль ДНК
Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most…
Упаковка ДНК
Eukaryotes have large genomes compared to prokaryotes. In order to fit their genomes into a cell, eukaryotes must pack their DNA tightly inside the…
Организация генов
The genomes of eukaryotes can be structured in several functional categories. A strand of DNA is comprised of genes and intergenic regions. Genes…
Кариотипирование
Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated…
Ауторепликация в прокариотах
DNA replication has three main steps: initiation, elongation, and termination. Replication in prokaryotes begins when initiator proteins bind to…
Ауторепликация в эукариотах
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity…
Редактирование
Synthesis of new DNA molecules starts when DNA polymerase links nucleotides together in a sequence that is complementary to the template DNA…
Репарация неспаренных оснований
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires…
Эксцизионная репарация нуклеотидов
Exposure to mutagens can damage DNA and result in bulky lesions that distort the double-helix structure or impede proper transcription. Damaged DNA…
Мутации
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors.…
Транскрипт
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene…
Перевод
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it…
Бактериальная трансформация
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied…
Складной и характеристика Био-отзывчивого робота от ДНК оригами
The DNA nanorobot is a hollow hexagonal nanometric device, designed to open in response to specific stimuli and present cargo sequestered inside.…
Метод ЧИП-экзо: Выявление белок-ДНК взаимодействий с Near пар оснований Precision
Chromatin immunoprecipitation (ChIP) is an indispensable tool in the fields of epigenetics and gene regulation that isolates specific protein-DNA…
Применение Остановлен поток Кинетика методы по расследованию Механизм действия белков репарации ДНК
Transient kinetic analysis is indispensable for understanding the workings of biological macromolecules, since this approach yields mechanistic…
Атомно-силовая микроскопия Исследования распознавания повреждения ДНК при восстановлении эксцизии нуклеотидов
AFM imaging is a powerful technique for the study of protein-DNA interactions. This single molecule method allows the simultaneous resolution of…

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