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Axon Stretch Growth: The Mechanotransduction of Neuronal Growth
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
Axon Stretch Growth: The Mechanotransduction of Neuronal Growth

Axon Stretch Growth: The Mechanotransduction of Neuronal Growth

DOI:
10.3791/2753-v

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11:46 min

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August 10, 2011

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, ,
1Departments of Biomedical Engineering,New Jersey Institute of Technology, 2Graduate School of Biomedical Sciences,University of Medicine and Dentistry of New Jersey

Chapters

  • 00:05Title
  • 01:41Overview of the Axon Stretch Growth Bioreactor System
  • 03:06Preparation of Bioreactor Chamber
  • 05:49Neuronal Culture
  • 07:20Axon Stretch Growth
  • 08:48Time-lapse Imaging of Axon Stretch Growth
  • 10:56Conclusion

Summary

Automatic Translation

Automatic Translation

A unique tissue engineering method was developed to elongate numerous nerve fibers in culture by recapitulating axon stretch growth; a form of nervous system growth whereby nerves elongate in conjunction with growth of the enlarging body.

Tags

Axon Stretch GrowthMechanotransductionNeuronal GrowthPre-synaptic Embryonic DevelopmentGrowth ConeSkeletal GrowthNeuronal SomataAxon TerminalsSecondary Mode Of Neuronal GrowthElongation Of The AxonMaturation Of Short Embryonic ProcessesAdult Nervous SystemIn Vitro StudyBioreactorsTension ApplicationNeuronal CulturesMicro-manipulated Towing SubstrateGrowth Cone ExtensionStationary SubstrateRecapitulating Skeletal GrowthDorsal Root Ganglia Neurons

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