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JoVE Journal
Bioengineering

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Nonhuman Primate Lung Decellularization and Recellularization Using a Specialized Large-organ Bioreactor
 

Nonhuman Primate Lung Decellularization and Recellularization Using a Specialized Large-organ Bioreactor

Article doi: 10.3791/50825
December 15th, 2013

Summary December 15th, 2013

Whole-organ decellularization produces natural biological scaffolds that may be used for regenerative medicine. The description of a nonhuman primate model of lung regeneration in which whole lungs are decellularized and then seeded with adult stem cells and endothelial cells in a bioreactor that facilitates vascular circulation and liquid media ventilation is presented.

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