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JoVE Journal Bioengineering
Etablering af et kirurgisk induceret model i mus for at undersøge den beskyttende rolle i Progranulin i Slidgigt
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Etablering af et kirurgisk induceret model i mus for at undersøge den beskyttende rolle i Progranulin i Slidgigt

Article DOI: 10.3791/50924-v • 07:58 min • February 25th, 2014
February 25th, 2014 •
1, 1, 2
1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Orthopaedic Surgery, New York University Medical Center

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Vi beskriver en protokol for en destabilisering af den mediale menisk (DMM) model i mus, et effektivt redskab for slidgigt (OA) forskning. Desuden har vi påvist, at mangel på progranulincan overdrive OA udvikling og progression ved hjælp af denne model, hvilket indikerer, at progranulin spiller en beskyttende rolle i patogenesen for OA.

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Bioteknik mus Brusk kirurgi slidgigt slidgigt progranulin destabilisering af mediale menisk (DMM)
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