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JoVE Journal
Bioengineering

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建立了外科手术引起的小鼠模型,以调查的progranulin在骨性关节炎的保护作用
 
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建立了外科手术引起的小鼠模型,以调查的progranulin在骨性关节炎的保护作用

Article DOI: 10.3791/50924-v 07:58 min February 25th, 2014
February 25th, 2014

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Summary

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Click here for the English version.

我们描述了一个协议内侧半月板(DMM)模型小鼠中,一种有效的工具,骨关节炎(OA)研究的不稳定。此外,我们已经证明progranulincan夸大OA的发生和发展利用该模型的不足,表明progranulin的发挥在OA的发病机制中起保护作用。

Tags

生物工程,第84,鼠标,软骨,外科,骨关节炎,退行性关节炎,progranulin的,内侧半月板不稳定(DMM)
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