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Gene-miljø Interaktion Modeller til unmask modtagelighed mekanismer i Parkinsons sygdom
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Gene-miljø Interaktion Modeller til unmask modtagelighed mekanismer i Parkinsons sygdom

Article DOI: 10.3791/50960-v • 08:09 min • January 7th, 2014
January 7th, 2014 •
1, 1, 2, 1
1Center for Health Sciences, SRI International, 2Department of Chemistry and Biochemistry, University of California-Santa Cruz

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Lipoxygenase (LOX) isozymer kan generere produkter, der kan øge eller mindske neuroinflammation og neurodegeneration. En interaktionsundersøgelse mellem gen og miljø kunne identificere LOX isozymspecifikke virkninger. Ved hjælp af 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP) model af nigrostriatal skader i to LOX isozym-mangelfulde transgene linjer giver mulighed for sammenligning af bidraget fra LOX isozymer på dopaminergisk integritet og inflammation.

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Medicin MPTP dopamin Iba1 TH GFAP lipoxygenase transgene gen-miljø interaktioner mus Parkinsons sygdom neurodegeneration neuroinflammation
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