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Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

Article DOI: 10.3791/51917 • 08:41 min • October 27th, 2014
October 27th, 2014 •
1, 1
1Program in Developmental Therapeutics, Fox Chase Cancer Center

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This method was developed with the goal of delivering a steady drug solution via the carotid artery, to assess the pharmacokinetics of novel drugs in mouse models.

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Carotid Artery Infusions Pharmacokinetic Analysis Pharmacodynamic Analysis Taxanes Mice Models Drug Delivery Drug Concentrations Mass Spectrometry Paclitaxel Continuous Arterial Infusion Blood Samples Retro-orbital Bleeds Carotid Artery Catheterization
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