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Menneskelig Dupuytrens
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Menneskelig Dupuytrens

Article DOI: 10.3791/52534-v • 08:59 min • April 18th, 2015
April 18th, 2015 •
1, 2, 3, 4, 4,5, 1,6
1Department of Molecular Cell Biology, Cancer Genomics Centre and Centre for Biomedical Genetics, Leiden University Medical Center, 2Department of Orthopedic Surgery, Academic Medical Center, 3Department of Plastic, Reconstructive and Hand Surgery, Academic Medical Center, 4Department of Orthopedic Surgery, Mayo Clinic, 5Department of Biochemistry and Molecular Biology, Mayo Clinic, 6Department of Dermatology, Leiden University Medical Center

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Dupuytrens sykdom (DD) er en fibroproliferative sykdom i håndflaten. Her presenterer vi en protokoll til kultur reseksjonsnivå prøver fra DD i en tredimensjonal (3D) kultur system. Slike korttidskultur systemet tillater preservering av 3D-strukturen og molekylære egenskaper av fibrotisk vev.

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Medisin fibrose Dupuytrens sykdom TGFp 3D kultur system Compound skjerm Ekstracellulær matrise
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