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En højt gennemløb, Multipleksede og målrettet proteomiske CSF Assay at kvantificere neurodegenerative Biomarkører og apolipoprotein E Isoformer status

Article DOI: 10.3791/54541-v • 07:08 min • October 20th, 2016
October 20th, 2016 •
*1, *1, 1, 1, 2, 3, 4, 5, 1
1Centre for Translational Omics, Genetics and Genomic Medicine Deptartment, Great Ormond Street Institute of Child Health, University College London, 2Dementia Research Centre, Institute of Neurology, University College London, 3Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, 4Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, 5Great Ormond Street Hospital for Children, University College London
* These authors contributed equally

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Vi beskriver en high-throughput, multiplex, og målrettet proteomik cerebrospinalvæske (CSF) assay udviklet med potentiale for klinisk oversættelse. Testen kan kvantificere potentielle markører og risikofaktorer for neurodegeneration, såsom apolipoprotein E-varianter (E2, E3 og E4), og måle deres allel udtryk.

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Medicin CSF målrettede proteomics Multiple Reaction Monitoring apolipoprotein E isoform demens biomarkør tandem massespektrometri multiplex
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