Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

The aim of this video is to show you detailed and generalized protocols for the synthesis and purification of benzimidazolium salts, and subsequently, their palladium n-heterocyclic carbene complexes. The video also aims to show you detailed and generalized protocols for testing the catalytic activity of the synthesized complexes in carbon-carbon bond-forming reactions, such as arylation, and Suzuki-Miyaura cross-coupling. After watching this video, you should have a good understanding of how to synthesize and purify these compounds, as well as how to test the catalytic activity of the complexes in arylation and Suzuki-Miyaura reactions.

Protocol demonstration will start with the generalized method for the synthesis and purification of benzimidazolium salts. This will be followed by the generalized method for the synthesis and purification of palladium n-heterocyclic carbene complexes. Finally, the generalized methods for testing the catalytic activity of the complexes in arylation and then Suzuki-Miyaura reactions will be shown.